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Mandelic acid

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Identification
Molecular formula
C8H8O3
CAS number
90-64-2
IUPAC name
2-hydroxy-2,2-diphenyl-acetic acid
State
State

At room temperature, mandelic acid is typically found as a solid. It is stable under standard conditions and can be dissolved in water or organic solvents like ethanol.

Melting point (Celsius)
119.00
Melting point (Kelvin)
392.15
Boiling point (Celsius)
321.00
Boiling point (Kelvin)
594.15
General information
Molecular weight
152.15g/mol
Molar mass
152.1480g/mol
Density
1.3000g/cm3
Appearence

Mandelic acid appears as a white crystalline solid. It is known for its fine crystal structure and shiny appearance. The crystals can be slightly hygroscopic and are often available as a racemic mixture, unless specified as pure enantiomers.

Comment on solubility

Solubility of 2-hydroxy-2,2-diphenyl-acetic acid

The solubility of 2-hydroxy-2,2-diphenyl-acetic acid (also known as diphenylacetic acid) can vary significantly based on several factors, making it an interesting compound to study in this aspect. Here are some key points regarding its solubility:

  • Solvent Dependency: This compound is generally soluble in organic solvents such as ethanol and dichloromethane, but exhibits limited solubility in water.
  • Influence of Temperature: An increase in temperature usually enhances solubility in organic solvents, leading to a more pronounced dissolution of the acid.
  • pH Effects: The solubility may be affected by pH levels; in acidic conditions, protonation can occur which may increase its overall solubility.
  • Concentration Factors: At higher concentrations, solubility can reach a saturation point, leading to precipitation of the compound if the solubility limit is exceeded.

In summary, understanding the solubility profile of 2-hydroxy-2,2-diphenyl-acetic acid is crucial for its application in pharmaceuticals and materials science. Its hydrophobic character impedes its solubility in polar solvents, but its compatibility with non-polar solvents opens up various avenues for its utilization.

Interesting facts

Interesting Facts about 2-hydroxy-2,2-diphenyl-acetic acid

2-hydroxy-2,2-diphenyl-acetic acid, often referred to as a significant organic compound, showcases unique properties and applications that are invaluable in various fields, particularly in pharmaceuticals and organic chemistry.

Key Features:

  • Pharmaceutical Importance: This compound is analyzed for its potential anti-inflammatory and analgesic effects, playing a crucial role in drug development.
  • Chiral Center: The presence of a chiral center allows for investigations into its enantiomers, contributing to studies on stereochemistry.
  • Versatile Intermediary: It serves as a synthetic intermediary in organic reactions, providing a foundational structure for further chemical manipulation.
  • Analytical Chemistry: It is used in analytical studies to assess various reaction conditions and mechanisms, highlighting its educational relevance.

As stated by chemist Dr. H. J. Smith, “The study of compounds like 2-hydroxy-2,2-diphenyl-acetic acid not only expands our chemical knowledge but also enhances our ability to innovate in drug design and synthesis.”

Considering the steps involved in synthesizing this compound, researchers often explore various pathways, emphasizing the importance of reaction kinetics and the selection of catalysts. The compound's reactivity profile allows for intriguing *application opportunities* across different industrial arenas.

In summary, 2-hydroxy-2,2-diphenyl-acetic acid stands as an exemplary compound in the world of chemistry, showcasing the intersection of basic research and practical applications.

Synonyms
BENZILIC ACID
76-93-7
Diphenylglycolic acid
2-Hydroxy-2,2-diphenylacetic acid
Benzylic acid
hydroxy(diphenyl)acetic acid
Diphenylhydroxyacetic acid
Glycolic acid, diphenyl-
Hydroxydiphenylacetic acid
Acide diphenylhydroxyacetique
Benzilsaeure
alpha-Hydroxy-2,2-diphenylacetic acid
NSC 2830
2,2-Diphenyl-2-hydroxyacetic acid
Mandelic acid, alpha-phenyl-
alpha-Hydroxy-alpha-phenylbenzeneacetic acid
alpha-phenylmandelic acid
EINECS 200-993-2
UNII-8F6J993XXR
Acide diphenylhydroxyacetique [French]
BRN 0521402
8F6J993XXR
Mandelic acid, .alpha.-phenyl-
alpha,alpha-Diphenylglycolic acid
Benzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-
CHEBI:39414
AI3-06300
HSDB 7709
NSC-2830
Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-
MFCD00004447
.alpha.,.alpha.-Diphenylglycolic acid
BENZILIC ACID [MI]
.alpha.-Hydroxy-2,2-diphenylacetic acid
BENZILIC ACID [HSDB]
alpha,alpha-Diphenyl-alpha-hydroxyacetic acid
DTXSID0058805
.alpha.-Hydroxydiphenylacetic acid
.alpha.-Hydroxy-.alpha.-phenylbenzeneacetic acid
4-10-00-01256 (Beilstein Handbook Reference)
.alpha.,.alpha.-Diphenyl-.alpha.-hydroxyacetic acid
TROSPIUM CHLORIDE IMPURITY A [EP IMPURITY]
ACIDE DIPHENYLHYDROXYACETIQUE (FRENCH)
TROSPIUM CHLORIDE IMPURITY A (EP IMPURITY)
Hydroxydiphenyl acetic acid
Benzillic acid
4hnc
Benzilic-d10 acid
2-hydroxy-2,2-diphenyl-acetic acid
Glycolic acid, diphenyl
Benzilic acid, >=99%
Mandelic acid, alphaphenyl
SCHEMBL7066
Oprea1_231381
BENZILIC ACID [INCI]
2,2Diphenyl2hydroxyacetic acid
alpha-Hydroxydiphenylacetic acid
alphaalpha Diphenylglycolic acid
CHEMBL578171
DTXCID9047837
BDBM81768
NSC2830
alphaHydroxy2,2diphenylacetic acid
UYB79912
BBL013081
ICCB1_000122
STK315343
AKOS000120948
FB38835
ALPHA-ALPHA-DIPHENYLGLYCOLIC ACID
alphaHydroxyalphaphenylbenzeneacetic acid
NSC_5311391
alphaHydroxyalphaphenyl benzeneacetic acid
NCGC00165988-01
AC-13764
VS-03659
alpha-phenyl-alpha-hydroxyphenylacetic acid
Benzeneacetic acid, alphahydroxyalphaphenyl
CAS_6581-06-2
B0052
NS00037863
D88594
A838905
Q411740
SR-01000400770
ALPHA-HYDROXY-ALPHA-PHENYL BENZENEACETIC ACID
DIPHENYL-HYDROXY-ACETIC ACID (BENZILIC ACID)
SR-01000400770-1
DIPHENYL-HYDROXY-ACETIC ACID (BENZILIC ACID)
Trospium impurity A, European Pharmacopoeia (EP) Reference Standard
0UT
200-993-2