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Naproxen

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Identification
Molecular formula
C14H14ClNO
CAS number
22204-53-1
IUPAC name
[2-hydroxy-3-(1-naphthyl)propyl]-isopropyl-ammonium;chloride
State
State

At room temperature, Naproxen is typically in a solid state.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
233.50
Boiling point (Kelvin)
506.70
General information
Molecular weight
252.24g/mol
Molar mass
252.2420g/mol
Density
1.0040g/cm3
Appearence

Naproxen appears as a white to off-white crystalline powder. This compound is often odorless or has a light characteristic odor. In its pure form, it may have a slightly bitter taste.

Comment on solubility

Solubility Characteristics of [2-hydroxy-3-(1-naphthyl)propyl]-isopropyl-ammonium;chloride

The solubility of [2-hydroxy-3-(1-naphthyl)propyl]-isopropyl-ammonium;chloride, often referred to in shorthand as iPr-Nap, can be quite intriguing due to its complex structure. Here are key points to consider regarding its solubility:

  • Polar and Ionic Interactions: As an ammonium salt, the presence of the chloride ion suggests that iPr-Nap may exhibit enhanced solubility in polar solvents such as water. The ionic nature allows it to interact favorably with water molecules.
  • Hydroxyl Group Influence: The hydroxyl (-OH) group in the structure increases hydrophilicity, potentially promoting solubility in aqueous solutions. This functional group can form hydrogen bonds, further stabilizing the compound in solution.
  • Hydrophobic Character: The attached naphthalene moiety introduces hydrophobic characteristics, which may limit solubility in non-polar solvents but can affect its behavior in mixed solvent systems.
  • Temperature Dependence: Like many compounds, solubility may vary with temperature. Typically, warmer conditions enhance solubility for salts but may have differing effects based on the solvent allowed.

In summary, the solubility of [2-hydroxy-3-(1-naphthyl)propyl]-isopropyl-ammonium;chloride is primarily dictated by both ionic interactions and its functional groups. While it is likely soluble in polar solvents, care should be taken when considering solubility in non-polar media due to the naphthyl group. As always, empirical testing is essential for precise solubility data.

Interesting facts

Interesting Facts about [2-hydroxy-3-(1-naphthyl)propyl]-isopropyl-ammonium;chloride

[2-hydroxy-3-(1-naphthyl)propyl]-isopropyl-ammonium chloride, often referred to as a complex organic ammonium compound, captivates chemists and researchers alike due to its unique structure and potential applications. Here are some fascinating insights:

  • Dual Functionality: This compound exhibits both hydroxyl and naphthyl functionalities, making it a versatile building block in organic synthesis and medicinal chemistry.
  • Potential Pharmaceuticals: Compounds of this nature are often investigated for their biological activities, particularly in drug development targeting various diseases.
  • Chirality: The presence of chirality in the molecule can lead to different stereoisomers with varying biological effects, highlighting the importance of stereochemistry in pharmaceutical applications.
  • Hydrophilic and Hydrophobic Balance: The unique combination of the hydroxyl group and the naphthyl moiety creates an intriguing balance between hydrophilic and hydrophobic characteristics, which can be crucial for drug solubility and permeability.
  • Research Potential: The chloride salt form provides easy manipulation in laboratory settings, opening avenues for further research on its reactivity and potential reactions with other compounds.

As with many organic compounds, the study of [2-hydroxy-3-(1-naphthyl)propyl]-isopropyl-ammonium chloride not only enhances our understanding of organic chemistry but also paves the way for innovative therapeutic approaches. The intricate relationship between its molecular structure and physiological effects makes it a compound of enduring interest!

Synonyms
alpha-((Isopropylamino)methyl)-1-naphthaleneethanol hydrochloride
1-NAPHTHALENEETHANOL, alpha-((ISOPROPYLAMINO)METHYL)-, HYDROCHLORIDE
22820-55-9
RefChem:232279