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Triflusal

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Identification
Molecular formula
C10H11F3NO4
CAS number
322-79-2
IUPAC name
[2-hydroxy-3-[3-(trifluoromethyl)phenyl]propyl] carbamate
State
State

Triflusal is in a solid state at room temperature.

Melting point (Celsius)
123.50
Melting point (Kelvin)
396.65
Boiling point (Celsius)
333.00
Boiling point (Kelvin)
606.15
General information
Molecular weight
358.20g/mol
Molar mass
358.2200g/mol
Density
1.3940g/cm3
Appearence

Triflusal is a crystalline solid. It is typically characterized by its white to off-white color. The compound is often found in a powder form.

Comment on solubility

Solubility of [2-hydroxy-3-[3-(trifluoromethyl)phenyl]propyl] carbamate

The solubility of [2-hydroxy-3-[3-(trifluoromethyl)phenyl]propyl] carbamate can be influenced by several factors, which are essential for understanding its behavior in various solvents. Here are some key points:

  • Polarity: The presence of the hydroxyl group (-OH) enhances its solubility in polar solvents, such as water. This is due to the ability of the hydroxyl group to form hydrogen bonds with solvent molecules.
  • Functional Groups: The trifluoromethyl group (-CF3) is known to introduce a significant degree of hydrophobic character, which may impede its solubility in highly polar solvents.
  • Temperature: Like many organic compounds, the solubility may increase with temperature, allowing for a greater interaction between the molecules and the solvent.
  • pH Level: Since the compound has a carbamate group, changes in pH can affect ionization and, consequently, the solubility. In environments that are more basic, the compound may become more soluble.

In summary, the solubility of [2-hydroxy-3-[3-(trifluoromethyl)phenyl]propyl] carbamate can be described as a complex interplay of its unique chemical structure and environmental conditions. Understanding these principles is crucial when predicting its behavior in different settings.

Interesting facts

Interesting Facts about 2-hydroxy-3-[3-(trifluoromethyl)phenyl]propyl carbamate

This compound, known as a carbamate derivative, is notable for its various applications in the field of chemistry, particularly in pharmaceuticals and agrochemicals. Here are some captivating insights:

  • Pharmaceutical Relevance: Carbamates are important in medicinal chemistry. They often serve as intermediates in the synthesis of drugs due to their ability to form strong hydrogen bonds with biological targets.
  • Fluorine's Role: The presence of a trifluoromethyl group enhances the lipophilicity of the molecule, which can significantly alter its pharmacokinetic properties, potentially improving the bioavailability of the compound.
  • Versatile Intermediate: This compound can act as a building block for more complex chemical structures, further expanding its utility in creating novel therapeutic agents.
  • Environmental Impact: Many carbamates have been studied for their environmental effects, making them subjects of research in ecological toxicology to assess their influence on ecosystems.
  • Potential for Innovation: The unique properties lent by the trifluoromethyl group may lead to research into new agrochemicals designed for specific modes of action against pests while minimizing toxicity to non-target organisms.

As one navigates through the landscape of chemical compounds, 2-hydroxy-3-[3-(trifluoromethyl)phenyl]propyl carbamate exemplifies the intricate balance required in designing compounds that are both effective in their application and considerate of their environmental footprint. In the words of a prominent chemist, "The line between medicine and toxicity is so thin; we must tread carefully."

Synonyms
[2-hydroxy-3-[3-(trifluoromethyl)phenyl]propyl] carbamate
790-85-2
DTXSID20274524