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Carvedilol

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Identification
Molecular formula
C24H26N2O4
CAS number
72956-09-3
IUPAC name
2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenyl-propyl)amino]ethyl]benzamide
State
State

At room temperature, Carvedilol is a solid. It is typically handled as a powder for manufacturing pharmaceutical tablets or capsules.

Melting point (Celsius)
114.50
Melting point (Kelvin)
387.65
Boiling point (Celsius)
572.30
Boiling point (Kelvin)
845.45
General information
Molecular weight
406.48g/mol
Molar mass
406.4800g/mol
Density
1.2858g/cm3
Appearence

Carvedilol appears as a white to off-white powder.

Comment on solubility

Solubility of 2-Hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenyl-propyl)amino]ethyl]benzamide

The solubility characteristics of the compound 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenyl-propyl)amino]ethyl]benzamide (C24H26N2O4) are influenced by its complex chemical structure. Analyzing its solubility involves considering several factors:

  • Polarity: The presence of hydroxyl (-OH) groups enhances the polar character of the molecule, which may allow for solubility in polar solvents such as water.
  • Nonpolar parts: On the other hand, the aromatic and aliphatic hydrocarbon portions of this compound contribute hydrophobic interactions, suggesting lower solubility in polar solvents.
  • Hydrogen bonding: The ability to form hydrogen bonds with solvents can significantly impact solubility. The compound can interact favorably with water through these interactions.
  • Saturation and temperature: Solubility may also vary with temperature; generally, higher temperatures can lead to increased solubility for solid compounds.

In summary, the solubility of C24H26N2O4 is likely to exhibit mixed characteristics. This compound may be more soluble in organic solvents than in water, but the exact solubility will depend on the solvent environment and conditions. As with many complex organic compounds, experimental solubility data should be consulted for precise applications.

Interesting facts

Interesting Facts about 2-Hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenyl-propyl)amino]ethyl]benzamide

This compound, known for its complex structure, is an intriguing example of how modifications to aromatic systems can influence biological activity. Here are some captivating aspects worth noting:

  • Pharmacological Potential: Compounds like this one often exhibit properties that can lead to the development of pharmaceuticals, particularly in the realm of analgesics and anti-inflammatory agents.
  • Structural Diversity: The incorporation of multiple functional groups such as hydroxyl and amine functionalities enhances solubility and receptor binding. This allows for extensive exploration in medicinal chemistry.
  • Mechanism of Action: The unique arrangement of atoms allows this compound to interact with specific biological pathways, potentially influencing pain pathways or neurotransmitter systems.
  • Synthetic Routes: The synthesis of such compounds can involve multi-step reactions, showcasing the creativity and skill of chemists in developing complex molecules from simpler precursors.
  • Analog Development: The potential for creating analogs is vast. Small changes in the structure can lead to significant alterations in activity and efficacy, which is a fundamental concept in drug design.
  • Research Significance: Studying compounds like this contributes to our understanding of how different chemical structures impact biological activity, aiding in the quest for more effective treatments.

In conclusion, the exploration of 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenyl-propyl)amino]ethyl]benzamide represents a fascinating intersection of chemistry and biology. As research continues, the hope is that such compounds can lead to breakthroughs in healthcare and medicinal therapies.

Synonyms
labetalol
36894-69-6
Labetolol
Ibidomide
Albetol
Labetalolum
Normodyne
2-Hydroxy-5-(1-hydroxy-2-((4-phenylbutan-2-yl)amino)ethyl)benzamide
Labetalolum [INN-Latin]
AH 5158
5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide
2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide
HSDB 6537
EINECS 253-258-3
Labetalol (INN)
3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol
AH-5158A FREE BASE
CHEBI:6343
UNII-R5H8897N95
SCH-15719W FREE BASE
2-Hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)benzamide
Benzamide, 2-hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-
R5H8897N95
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide
DTXSID2023191
EC 253-258-3
36894-69-6 (free base)
Benzamide, 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-
LABETALOL [INN]
Labetalolum (INN-Latin)
Labetalol [INN:BAN]
2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide
R,S-Labetalol
kabetalol
labetalolo
2-Hydroxy-5-(1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl)benzamide
MFCD00242941
Labetalol (Standard)
Amipress (Salt/Mix)
Trandate (Salt/Mix)
Normodyne (Salt/Mix)
Spectrum_001607
LABETALOL [MI]
LABETALOL [HSDB]
Prestwick0_000277
Prestwick1_000277
Prestwick2_000277
Prestwick3_000277
Spectrum2_000863
Spectrum3_001581
Spectrum4_000184
Spectrum5_001010
LABETALOL [VANDF]
CHEMBL429
LABETALOL [WHO-DD]
SCHEMBL4582
Lopac0_000687
BSPBio_000154
BSPBio_003142
KBioGR_000727
KBioSS_002087
DivK1c_000474
SPBio_000905
SPBio_002373
BPBio1_000170
DTXCID603191
GTPL7207
BDBM25758
KBio1_000474
KBio2_002087
KBio2_004655
KBio2_007223
KBio3_002642
C07AG01
CHEBI:167638
NINDS_000474
Labetalol hydrochloride (Salt/Mix)
BCP31095
IDA16724
IDA16732
AH5158;Sch-15719W free base
AKOS015908406
CCG-204772
DB00598
DS-4652
HY-121383R
SDCCGSBI-0050665.P004
IDI1_000474
NCGC00015595-03
NCGC00015595-04
NCGC00015595-06
NCGC00015595-07
NCGC00015595-12
NCGC00015595-14
NCGC00015595-19
NCGC00089800-02
AC-18747
Labetolol;Albetol;Normodyne;Apo-Labetalol
SBI-0050665.P003
HY-121383
AB00053659
CS-0081835
NS00008578
C07063
C74903
D08106
AB00053659_13
EN300-1272609
A823444
L001344
Q958087
BRD-A07440155-003-05-6
BRD-A07440155-003-16-3
BRD-A07440155-003-25-4
5-(1-Hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)salicylamide
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzene-1-carboximidic acid
3-Carboxamido-4-hydroxy-.alpha.-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol
253-258-3
32780-40-8