Sulfasalazine | Solubility of Things

Identification

Molecular formula

C₁₈H₁₄N₄O₅S

CAS number

599-79-1

IUPAC name

2-hydroxy-5-[4-(2-pyridylsulfamoyl)phenyl]azo-benzoic acid

State

At room temperature, sulfasalazine is a solid, typically found in a powdered form. As with many pharmaceutical compounds, it is handled as a solid in its pure form, although it is often compounded into tablet form for medical use.

Melting point (Celsius)

240.00

Melting point (Kelvin)

513.00

Boiling point (Celsius)

0.00

Boiling point (Kelvin)

0.00

General information

Molecular weight

398.39g/mol

Molar mass

398.4120g/mol

Density

1.5600g/cm³

Appearence

Sulfasalazine is typically an orange-yellow, crystalline powder. It is often used in a micronized form to improve solubility and bioavailability, which maintains the orange hue but may appear as finer granules or a consistent powder.

Comment on solubility

Solubility of 2-hydroxy-5-[4-(2-pyridylsulfamoyl)phenyl]azo-benzoic acid

The solubility of 2-hydroxy-5-[4-(2-pyridylsulfamoyl)phenyl]azo-benzoic acid, a complex organic compound with the formula C₁₈H₁₄N₄O₅S, can be influenced by various factors. Here are some key points to consider:

Polarity: The presence of both hydrophilic (water-attracting) and lipophilic (fat-attracting) functional groups in its structure affects its general solubility in different solvents.
Solvent Interaction: This compound may exhibit greater solubility in polar solvents like water and alcohols due to its hydroxyl (-OH) group and the sulfonamide functional group, which can form hydrogen bonds.
pH Dependency: Solubility can also vary with changes in pH, as the carboxylic acid group present might influence protonation states and thus solubility behavior.
Temperature Effects: Increasing temperature is generally known to enhance solubility, particularly for solid compounds in liquid solutions.

In conclusion, while 2-hydroxy-5-[4-(2-pyridylsulfamoyl)phenyl]azo-benzoic acid demonstrates the potential for solubility in specific solvent systems, it is crucial to consider the interactions of its functional groups and environmental conditions. As the saying goes, "Like dissolves like," which aptly summarizes the complex interactions that dictate solubility in the realm of chemistry.

Interesting facts

Interesting Facts about 2-Hydroxy-5-[4-(2-Pyridylsulfamoyl)phenyl]azo-benzoic Acid

2-Hydroxy-5-[4-(2-pyridylsulfamoyl)phenyl]azo-benzoic acid is a fascinating compound with several unique attributes. This compound is part of a larger class known for their azo linkages, which are characterized by the presence of a nitrogen-nitrogen double bond (-N=N-). Here are some intriguing aspects:

Dye Chemistry: The compound is often explored in dye chemistry due to its vivid colors and potential use in textiles and biological applications.
Pharmaceutical Potential: The sulfamoyl group may contribute to the compound’s biological properties, making it of interest in pharmaceuticals, particularly in the development of new antibacterial agents.
pH Sensitivity: The presence of the hydroxyl group can lead to pH-sensitive behavior, enabling applications in sensor technology, where changes in pH can affect its color and solubility.
Analytical Applications: It can serve as a colorimetric reagent in analytical chemistry, where it may be used for detecting various metal ions in solution.
Structure-Activity Relationship (SAR): The multiple functional groups present in the compound allow for extensive studies on its SAR, helping chemists understand how structural changes can affect biological activity.

In summary, 2-hydroxy-5-[4-(2-pyridylsulfamoyl)phenyl]azo-benzoic acid is not merely a molecule but a gateway to numerous research possibilities. Its complex structure and varied functional groups signify its potential in various fields, making it a subject of interest among both chemists and researchers alike.

Synonyms

sulfasalazine

599-79-1

Salicylazosulfapyridine

Azulfidine

Salazosulfapyridine

Sulphasalazine

Salazopyrin

Asulfidine

Benzosulfa

Salazopyridin

Accucol

Azopyrin

Sulcolon

Colo-Pleon

Salazopiridazin

Azopyrine

Reupirin

Salisulf

Salazosulfapyridin

Sulfasalazina

Sulfasalazinum

w-t Sasp oral

Azulfidine EN

Sulfasalazin

Sulfazalazine

Azulfidine EN-tabs

SASP

Salazosulfapiridina

Salazosulfapyridinum

Sas-500

5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid

S.A.S.-500

5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid

4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene

5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid

2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid

NSC 667219

5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic Acid

MFCD00057363

CHEBI:9334

NSC 203730

S.A.S. 500

Sulfasalazopyridine

(E)-2-hydroxy-5-((4-(N-(pyridin-2-yl)sulfamoyl)phenyl)diazenyl)benzoic acid

Benzoic acid, 2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]-

3XC8GUZ6CB

Sulfasalazine (Azulfidine)

NSC-203730

NSC-667219

Benzoic acid, 2-hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)-

S.A.S.

737754-28-8

Azosulfidin

DTXSID0021256

2-hydroxy-5-[[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl]benzoic acid

2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid

5-[p-(2-Pyridylsulfamoyl)phenylazo]salicylic acid

2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID

NSC203730

NSC667219

Salicylic acid, 5-((p-(2-pyridylsulfamoyl)phenyl)azo)-

NCGC00090903-01

Salazo-sulfapyridinum

CAS-599-79-1

2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic acid

2-hydroxy-5-[(E)-{4-[(pyridin-2-ylamino)sulfonyl]phenyl}diazenyl]benzoic acid

5-[p-(2-Pyridylsulfamyl)phenylazo]salicylic acid

(3Z)-6-Oxo-3-[[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazinylidene]cyclohexa-1,4-diene-1-carboxylic acid

DTXCID401256

Sulfasalazinum [INN-Latin]

Sulfasalazina [INN-Spanish]

Salicylic acid, 5-[[p-(2-pyridylsulfamoyl)phenyl]azo]-

2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid

Salazosulfapyridinum [INN-Latin]

Salazosulfapiridina [INN-Spanish]

SI-88

2-Hydroxy-5-((4-(N-(pyridin-2-yl)sulfamoyl)phenyl)diazenyl)benzoic acid

2-hydroxy-5-[(E)-2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl]benzoic acid

Azulfidine (TN)

SAS

SMR000059146

Sulphasalazine, N-

CCRIS 4713

HSDB 3395

13gs

5-(p-(2-Pyridylsulfamoyl)phenylazo)salicylic acid

SR-05000001721

EINECS 209-974-3

UNII-3XC8GUZ6CB

5-[[p-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid

Sulfasalazine (USP/INN)

BRN 0356241

Iwata

Prestwick_848

Sulfasalazine [USAN:USP:INN:BAN]

Spectrum_000998

Sulfasalazine (Standard)

Prestwick0_000520

Prestwick1_000520

Prestwick2_000520

Prestwick3_000520

Spectrum2_001216

Spectrum3_001364

Spectrum4_000347

Spectrum5_001443

SULFASALAZINE [MI]

CHEMBL421

Epitope ID:122672

SULFASALAZINE [INN]

SCHEMBL4514

SCHEMBL4515

Salazosulfapyridine (JP18)

SULFASALAZINE [HSDB]

SULFASALAZINE [IARC]

SULFASALAZINE [USAN]

SCHEMBL18490

BSPBio_000479

BSPBio_002888

KBioGR_000753

KBioGR_002314

KBioSS_001478

KBioSS_002316

SULFASALAZINE [VANDF]

5-22-08-00433 (Beilstein Handbook Reference)

MLS000759399

MLS001424109

MLS006011702

BIDD:GT0161

DivK1c_000860

SPECTRUM1500552

SULFASALAZINE [MART.]

SPBio_001032

SPBio_002400

SULFASALAZINE [USP-RS]

SULFASALAZINE [WHO-DD]

SULFASALAZINE [WHO-IP]

BPBio1_000527

CHEMBL100848

CHEMBL242373

GTPL4840

SCHEMBL1079598

SCHEMBL1229516

CHEMBL1206016

SCHEMBL10289061

CHEBI:94500

HMS502K22

KBio1_000860

KBio2_001478

KBio2_002314

KBio2_004046

KBio2_004882

KBio2_006614

KBio2_007450

KBio3_002108

KBio3_002794

SALAZOSULFAPYRIDINE [JAN]

cMAP_000018

NCEXYHBECQHGNR-QZQOTICOSA-N

NINDS_000860

OQANPHBRHBJGNZ-BKUYFWCQSA-N

OQANPHBRHBJGNZ-UHFFFAOYSA-N

HMS1569H21

HMS1921C05

HMS2051J21

HMS2090P13

HMS2092K07

HMS2096H21

HMS2232H07

HMS3370D16

HMS3393J21

HMS3655G07

HMS3713H21

HMS3871J13

HMS3884E21

Pharmakon1600-01500552

SULFASALAZINE [ORANGE BOOK]

ALBB-033361

BCP13311

SULFASALAZINE [EP MONOGRAPH]

Tox21_111037

Tox21_201239

Tox21_300541

BDBM50097125

BDBM50103596

CCG-39145

DL-510

HY-14655R

NSC757330

s1576

SULFASALAZINE [USP MONOGRAPH]

SULFASALAZINUM [WHO-IP LATIN]

2-hydroxy-5-(2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl)benzoic acid

AKOS002311709

AKOS025116975

AKOS026749974

AKOS037515748

Tox21_111037_1

WLN: T6NJ BSWMR DNUNR DQ CVQ

AS27942

CCG-100987

DB00795

HS-0062

NC00237

NSC-757330

IDI1_000860

SMP2_000059

NCGC00016518-01

NCGC00090903-02

NCGC00090903-03

NCGC00090903-04

NCGC00090903-05

NCGC00090903-06

NCGC00090903-07

NCGC00090903-08

NCGC00090903-09

NCGC00090903-11

NCGC00186644-01

NCGC00254313-01

NCGC00258791-01

AC-20497

HY-14655

PD087097

SMR004703430

SY052318

SBI-0051526.P003

DB-017797

NS00011872

S0580

SW196979-4

C07316

D00448

EN300-119546

H10652

AB00052101-04

AB00052101-06

AB00052101_07

AB00052101_08

Q420035

SR-05000001721-1

SR-05000001721-2

SR-05000001721-3

Sulfasalazine, analytical standard, >=98% (HPLC)

BRD-K10670311-001-06-4

BRD-K10670311-001-08-0

BRD-K10670311-001-14-8

BRD-K10670311-001-15-5

Q27166356

Q63398427

F2173-1125

Z1521554012

4-(Pyridyl-2-amidosulfonyl)-3''-carboxy-4''-hydroxyazobenzene

Sulfasalazine, European Pharmacopoeia (EP) Reference Standard

2-hydroxy-5-[(E)-[4-(2-pyridylsulfamoyl)phenyl]azo]benzoic acid

5-{4-[(2-pyridylideneamino)sulfonyl]phenyldiazenyl}salicylic acid

Sulfasalazine, United States Pharmacopeia (USP) Reference Standard

(E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)phenyl)diazenyl)benzoic acid

2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)phenyl)diazenyl)benzoic acid

2-Hydroxy-5-((4-[(2-pyridinylamino)sulfonyl]phenyl)diazenyl)benzoic acid #

2-hydroxy-5-{(E)-[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid

2-HYDROXY-5-((4-((2-PYRIDINYLAMINO)SULFONYL)PHENYL)AZO)BENZOIC ACID [WHO-IP]

6-oxo-3-(2-[4-(n-pyridin-2-ylsulfamoyl)phenyl]hydrazono)cyclohexa-1,4-dienecarboxylic acid

Benzoic acid, 2-hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]diazenyl]-

2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic acid;5-[[p-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid;5-[p-(2-Pyri dylsulfamyl)phenylazo]salicylic acid

6-oxo-3-((4-(pyridin-2-ylsulfamoyl)phenyl) hydrazinylidene]cyclohexa-1,4-diene-1-carboxylic acid

6-oxo-3-(2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}hydrazin-1-ylidene)cyclohexa-1,4-diene-1-carboxylic acid

6-oxo-3-[[4-(2-pyridinylsulfamoyl)phenyl]hydrazinylidene]-1-cyclohexa-1,4-dienecarboxylic acid