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Iodosalicylic Acid

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Identification
Molecular formula
C7H5IO3
CAS number
2180-51-2
IUPAC name
2-hydroxy-5-iodo-benzoic acid
State
State

At room temperature, Iodosalicylic acid is a solid. It is stable under normal conditions of use and storage, but as with many iodinated compounds, it should be handled with care to avoid unnecessary exposure or release.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
381.50
Boiling point (Kelvin)
654.70
General information
Molecular weight
280.02g/mol
Molar mass
280.0080g/mol
Density
2.1915g/cm3
Appearence

Iodosalicylic acid typically appears as a white to off-white crystalline powder. It can have a very faint yellowish tint, but in its pure form, it is generally white.

Comment on solubility

Solubility of 2-hydroxy-5-iodo-benzoic acid

2-hydroxy-5-iodo-benzoic acid, often referred to in chemical contexts as salicylic acid analog, demonstrates noteworthy solubility characteristics that can influence its applications. Generally, the compound is moderately soluble in various solvents, with the solubility largely governed by the presence of both hydrophilic (hydroxyl group) and hydrophobic (iodo group) functional groups.

Solubility Details:

  • Water: It exhibits limited solubility in water; this is primarily due to the competition between hydrogen bonding from the hydroxyl group and the steric hindrance introduced by the iodine atom.
  • Organic Solvents: The compound generally shows greater solubility in polar organic solvents such as ethanol and methanol, as these solvents can better accommodate the polar hydroxyl functionality.
  • pH Influence: The solubility can also be affected by the pH of the solution, highlighting the potential for enhanced solubility in alkaline solutions due to the deprotonation of the carboxylic acid group.

In summary, the solubility of 2-hydroxy-5-iodo-benzoic acid is quite context-dependent, influenced by factors such as solvent polarity, temperature, and pH. Understanding these solubility traits can be crucial for applications in pharmaceuticals and biochemical research, where proper solvation is key for effective activity.

Interesting facts

Interesting Facts about 2-Hydroxy-5-iodo-benzoic Acid

2-Hydroxy-5-iodo-benzoic acid, often shortened to HI-BA, is a fascinating compound that plays significant roles in both industrial and research settings. Here are some intriguing aspects:

  • Applications in Pharmaceuticals: This compound is known for its potential use in the synthesis of various pharmaceutical agents. The presence of both hydroxy and iodo functional groups makes it a valuable intermediate in drug development.
  • Research in Material Science: HI-BA is also studied for its properties in polymer chemistry. Its unique structure allows for modifications that can enhance material performance, including electrical and thermal properties.
  • Environmental Impact: The iodine component of this compound can provide insight into environmental chemistry. Specifically, iodine can play a crucial role in biological pathways and tracking environmental pollutants.
  • Analytical Chemistry: Due to its distinct characteristics, 2-hydroxy-5-iodo-benzoic acid serves as a useful marker in various analytical techniques, offering a way to study complex reactions or reaction mechanisms.

Chemical Properties and Interactions

From a chemist's perspective, the interactions of HI-BA with various reagents showcase its versatility. It can undergo various reactions, including:

  • Substitution reactions due to the iodine atom, which can be replaced or modified in synthetic pathways.
  • Acid-base reactions, given the presence of the carboxylic acid group, which can influence its reactivity profoundly.

As noted by chemists, “Understanding the behavior of iodine-containing compounds like HI-BA is essential for advancing both synthetic and environmental chemistry”. The ability to manipulate its chemical structure opens pathways for innovation across multiple disciplines.

Conclusion

Overall, 2-hydroxy-5-iodo-benzoic acid is not just a simple compound but a gateway into advanced research and development in chemistry, pharmaceuticals, and environmental sciences. As research continues, its importance is likely to expand, revealing even more fascinating properties and applications.

Synonyms
5-Iodosalicylic acid
2-Hydroxy-5-iodobenzoic acid
119-30-2
Benzoic acid, 2-hydroxy-5-iodo-
SALICYLIC ACID, 5-IODO-
5-IODO-2-HYDROXYBENZOIC ACID
MFCD00002458
NSC 2789
EINECS 204-313-5
BRN 2090443
DTXSID10152281
NSC-2789
5-IodosalicylicAcid
5-Iodosalycilic acid, Tech.
2-hydroxy-5-iodo-benzoic acid
5-Jod-salicylsaure
5-iodosalicyclic acid
WLN: QVR BQ EI
SCHEMBL129664
3A6XQF5B67
CHEMBL3278559
DTXCID4074772
NSC2789
BCP24359
5-Iodosalicylic acid, technical grade
AKOS000121006
FI71697
Benzoic acid, 2-hydroxy-5-iodo-(9CI)
AC-23694
BP-11486
BS-14523
SY049057
DB-014579
CS-0075700
I0538
NS00023850
EN300-21476
D73875
F0001-0305
204-313-5