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Pirfenidone

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Identification
Molecular formula
C12H11NO
CAS number
53179-13-8
IUPAC name
2-hydroxy-8-(1-piperidylmethyl)-4-propyl-chromen-7-one
State
State

At room temperature, Pirfenidone is typically in a solid state as a crystalline powder.

Melting point (Celsius)
109.00
Melting point (Kelvin)
382.15
Boiling point (Celsius)
431.50
Boiling point (Kelvin)
704.65
General information
Molecular weight
185.23g/mol
Molar mass
185.2280g/mol
Density
1.3000g/cm3
Appearence

Pirfenidone appears as a white to pale yellow crystalline powder. It is usually provided in tablet form for medicinal uses. The compound is sparingly soluble in water but more soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol.

Comment on solubility

Solubility of 2-hydroxy-8-(1-piperidylmethyl)-4-propyl-chromen-7-one

The solubility of 2-hydroxy-8-(1-piperidylmethyl)-4-propyl-chromen-7-one (C12H11NO) can be influenced by various factors, including its chemical structure and functional groups. Understanding its solubility characteristics is crucial for applications in pharmaceuticals and related fields.

Factors Affecting Solubility

  • Polarity: The presence of the hydroxyl group (-OH) suggests potential for hydrogen bonding, which increases solubility in polar solvents like water.
  • Hydrophobic Regions: The propyl group and chromenone structure introduce hydrophobic characteristics, which may reduce solubility in aqueous environments.
  • Functional Groups: The piperidyl group can interact with various solvents, potentially enhancing the solubility in organic solvents.

Overall, the solubility of this compound may be described as:

  1. Likely moderate in polar solvents due to the presence of the hydroxyl group.
  2. Relatively lower in non-polar solvents because of its hydrophobic components.
  3. Variable in mixed solvents, depending on the balance between polar and non-polar characteristics.

In conclusion, while the exact solubility profile of C12H11NO can depend on specific conditions, it is reasonable to anticipate that its unique structure provides a balance between solubility in different solvent systems.

Interesting facts

Exploring 2-hydroxy-8-(1-piperidylmethyl)-4-propyl-chromen-7-one

2-hydroxy-8-(1-piperidylmethyl)-4-propyl-chromen-7-one, often recognized for its complex structure and fascinating properties, falls within the category of flavonoids. This compound boasts significant biological activities, making it a valuable subject of study in both the fields of medicinal chemistry and pharmacology.

Key Features:

  • Biological Activity: It has shown potential as an anti-inflammatory agent and may have therapeutic applications in managing various diseases due to its ability to modulate signaling pathways involved in inflammation.
  • Structure-Activity Relationship: The presence of the piperidylmethyl group is critical, contributing to its biological interactions and enhancing its pharmacological properties. This unique structural feature allows it to bind effectively to certain biological targets.
  • Natural Sources: Compounds similar to this chromenone derivative are often derived from natural sources, leading to interests in extracting and synthesizing them for pharmaceutical applications.
  • Research Interest: Ongoing studies investigate its role in neuroprotective effects, suggesting it could potentially support brain health and counteract neurodegenerative disorders.

Furthermore, the combination of hydroxyl and propyl groups enables the compound to engage in a multitude of interactions, significantly enhancing its solubility and biological activity. As noted by researchers, “the intricate dance of chemical bonding in compounds like 2-hydroxy-8-(1-piperidylmethyl)-4-propyl-chromen-7-one opens up new frontiers in drug discovery.”

In summary, 2-hydroxy-8-(1-piperidylmethyl)-4-propyl-chromen-7-one exemplifies how a seemingly complex molecule can reveal profound biochemical interplay, driving forward our understanding of its potential benefits in modern medicine.