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Pirfenidone

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Identification
Molecular formula
C12H11NO7
CAS number
53179-13-8
IUPAC name
2-hydroxy-8-(piperidin-1-ium-1-ylmethyl)-4-propyl-chromen-7-one;pyridine-3-carboxylate
State
State

At room temperature, pirfenidone is in a solid state, appearing as a crystalline powder. It is generally stable under normal conditions of use and storage.

Melting point (Celsius)
84.00
Melting point (Kelvin)
357.15
Boiling point (Celsius)
465.02
Boiling point (Kelvin)
738.17
General information
Molecular weight
185.16g/mol
Molar mass
185.1560g/mol
Density
1.3438g/cm3
Appearence

Pirfenidone appears as a white to pale yellow crystalline powder. It may have a faint, characteristic odor. The powder is solid at room temperature, and its color may vary slightly depending on the specific batch or purity level.

Comment on solubility

Solubility of 2-hydroxy-8-(piperidin-1-ium-1-ylmethyl)-4-propyl-chromen-7-one

The solubility of a compound is critical to understanding its potential applications and behavior in various environments. For the compound 2-hydroxy-8-(piperidin-1-ium-1-ylmethyl)-4-propyl-chromen-7-one; pyridine-3-carboxylate (C12H11NO7), the following points about its solubility can be considered:

  • Polarity: This compound contains both polar and nonpolar functional groups, leading to a potential for varied solubility depending on the solvent used.
  • Hydrophilicity: The presence of hydroxyl (-OH) and carboxylate groups suggests that it may have some solubility in polar solvents like water.
  • Nonpolar Solvents: The propyl chain may facilitate solubility in nonpolar organic solvents, making it versatile in different chemical environments.
  • pH Dependency: The solubility might be influenced by the pH of the solution due to the ionizable nature of the piperidinium and carboxylate moieties.

In general, one can anticipate that this compound will exhibit:

  1. Higher solubility in acidic conditions, where ionization could enhance its solubility.
  2. Limited solubility in basic conditions, which might lead to precipitation of the uncharged species.

Understanding these solubility characteristics is essential for applications in pharmaceuticals, where bioavailability often hinges on how well a compound dissolves in bodily fluids. The balance of polar and nonpolar attributes within the structure of this compound highlights its potential for complex solubility behavior.

Interesting facts

Interesting Facts about 2-Hydroxy-8-(piperidin-1-ium-1-ylmethyl)-4-propyl-chromen-7-one; Pyridine-3-carboxylate

This fascinating compound is notable for its unique structural attributes and potential applications in various fields of science. Here are some engaging facts about this molecule:

  • Versatile Applications: The compound exhibits potential applications in medicinal chemistry, particularly in developing new pharmaceuticals and therapeutic agents, thanks to its chromenone core, which is often associated with various biological activities.
  • Bioactivity: Compounds containing the chromenone structure have been studied extensively for their anti-inflammatory, antioxidant, and anticancer properties, making this compound a subject of interest in drug discovery.
  • Enhancement of Solubility: The piperidin-1-ium functional group may enhance the solubility of the compound in biological systems, facilitating its use as a drug candidate with improved bioavailability.
  • Chirality: Depending on the stereochemistry of the substituents, this compound can exhibit chirality, leading to the possibility of different enantiomers with varied biological efficacy and toxicity.
  • Research Potential: Research involving derivatives of this compound could lead to significant advancements in synthetic methodologies and understandings of structure-activity relationships in similar chemical families.

In summary, the compound 2-hydroxy-8-(piperidin-1-ium-1-ylmethyl)-4-propyl-chromen-7-one; pyridine-3-carboxylate holds promising avenues for future research due to its structural complexity and potential pharmacological properties. As scientists continue to explore its capabilities, there is a world of discovery awaiting beneath its molecular surface.