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Paracetamol

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Identification
Molecular formula
C8H9NO2
CAS number
103-90-2
IUPAC name
2-hydroxy-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
State
State

At room temperature, paracetamol is a solid. It is commercially available in various forms, including tablets, capsules, and powder. Its stability as a solid makes it suitable for long-term storage under proper conditions, avoiding moisture and excessive heat.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
387.00
Boiling point (Kelvin)
660.15
General information
Molecular weight
151.16g/mol
Molar mass
151.1630g/mol
Density
1.2637g/cm3
Appearence

Paracetamol is typically a white crystalline powder, characterized by its fine granular texture. It is odorless and possesses a slightly bitter taste, which is common for many pharmaceutical compounds. Under polarized light, the crystals may exhibit birefringence.

Comment on solubility

Solubility of 2-hydroxy-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide

The solubility of 2-hydroxy-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide in various solvents reveals interesting properties that are characteristic of compounds containing both hydrophilic and hydrophobic functional groups. This compound, with its multiple hydroxyl groups, indicates strong potential for hydrogen bonding, enhancing its solubility in polar solvents. Moreover, the presence of the 4-nitrophenyl moiety introduces a degree of lipophilicity due to its aromatic nature.

Here are some insights regarding its solubility:

  • Polar Solvents: This compound is expected to exhibit good solubility in water and other polar solvents due to its significant number of hydroxyl groups.
  • Non-polar Solvents: Conversely, solubility in non-polar solvents may be limited, reflecting the compound's hydrophilic nature.
  • pH Dependency: The solubility can also be influenced by pH, as ionization of functional groups may occur, further affecting solubility characteristics.

In conclusion, the intricate balance of hydrophilic and lipophilic interactions makes the solubility profile of 2-hydroxy-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide particularly noteworthy, rendering it soluble in water and other polar environments while potentially limiting its ability to dissolve in non-polar solvents.

Interesting facts

Interesting Facts about 2-hydroxy-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide

This intriguing compound, often recognized for its complex structure, is a prime example of how chemical modifications can enhance biological activity. Here are some compelling attributes that illustrate its significance:

  • Versatile Chemical Structure: The presence of both hydroxyl and acetamide functional groups emphasizes its ability to participate in various chemical reactions, making it a potential candidate for further synthetic modifications.
  • Biological Potential: Compounds with similar structures have been studied for their roles in pharmacology, pointing towards an ability to interact with biological systems, which could lead to the development of new therapeutic agents.
  • Synthesis Challenges: The multi-step synthesis required for this compound reflects the complexity often encountered in organic chemistry, providing real-world application scenarios where the skill of chemists is put to the test.
  • Research Opportunities: The incorporation of a nitrophenyl group suggests that this compound may exhibit unique electronic properties, thus opening doors for research into materials science and organic electronics.

Overall, 2-hydroxy-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide serves as an excellent case study in the fields of synthetic organic chemistry and medicinal chemistry. As scientists continue to explore its potential applications, it remains a fascinating subject for both academic research and practical applications.

Synonyms
CHEMBL283565
SCHEMBL2729367
DTXSID70946668
N-[1,3-Dihydroxy-1-(4-nitrophenyl)propan-2-yl]-2-hydroxyethanimidic acid