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Salicylamide

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Identification
Molecular formula
C13H11NO2
CAS number
65-45-2
IUPAC name
2-hydroxy-N-(2-hydroxy-2-phenyl-ethyl)-3-isopropyl-6-methyl-benzamide
State
State

At room temperature, salicylamide is in a solid state.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
340.00
Boiling point (Kelvin)
613.15
General information
Molecular weight
137.14g/mol
Molar mass
137.1410g/mol
Density
1.2100g/cm3
Appearence

Salicylamide typically appears as an off-white to beige crystalline powder. It is usually odorless and has a bitter taste. This compound is known for its stability under normal conditions, although it may gradually darken upon prolonged exposure to light.

Comment on solubility

Solubility of 2-hydroxy-N-(2-hydroxy-2-phenyl-ethyl)-3-isopropyl-6-methyl-benzamide

The solubility of 2-hydroxy-N-(2-hydroxy-2-phenyl-ethyl)-3-isopropyl-6-methyl-benzamide is influenced by its complex structure, which can hinder its dissolution in various solvents. Here are several key points regarding its solubility:

  • Polarity: This compound contains multiple hydroxyl groups, which are polar and may enhance solubility in polar solvents, such as water.
  • Hydrogen Bonding: The presence of hydroxyl groups allows for hydrogen bonding with water molecules, which can further improve solubility.
  • Hydrophobic Regions: The isopropyl and phenyl groups introduce hydrophobic characteristics, potentially reducing solubility in polar solvents.
  • Solvent Interactions: It may exhibit differing solubility properties in organic solvents (e.g., ethanol, methanol) compared to aqueous solutions.
  • Temperature Dependence: Solubility can also vary with temperature, typically increasing with higher temperatures.

In summary, while 2-hydroxy-N-(2-hydroxy-2-phenyl-ethyl)-3-isopropyl-6-methyl-benzamide may demonstrate **increased solubility in polar solvents** due to its hydroxyl functionalities, the presence of hydrophobic components may limit its overall solubility. Thus, its solubility profile is a balancing act between its polar and non-polar attributes.

Interesting facts

Exploring 2-hydroxy-N-(2-hydroxy-2-phenyl-ethyl)-3-isopropyl-6-methyl-benzamide

This intriguing compound, known as 2-hydroxy-N-(2-hydroxy-2-phenyl-ethyl)-3-isopropyl-6-methyl-benzamide, belongs to a class of organic molecules that have garnered interest in both synthetic and medicinal chemistry due to their unique structural features and potential biological activities.

Key Features

  • Hydroxyl Groups: The presence of two hydroxyl groups in the structure enhances its solubility and can potentially influence its reactivity and interaction with biological systems.
  • Benzamide Moiety: The benzamide functional group is known for its ability to mimic natural substances, making this compound a candidate for pharmaceuticals.
  • Substituents: The isopropyl and methyl substitutions introduce steric and electronic effects, which can greatly impact the compound’s biological activity and specificity.

Biological Relevance

Compounds like this one are often investigated for their therapeutic potentials, particularly in the fields of:

  • Anti-inflammatory Agents: The structural design can be tuned to develop new treatments.
  • Antioxidant Properties: Hydroxyl groups are frequently associated with the ability to neutralize free radicals, which is a crucial factor in cellular aging and disease progression.

Interesting Facts

Researchers often embrace such compounds for their ability to:

  • Act as lead compounds in drug discovery.
  • Be used in structure-activity relationship (SAR) studies to understand how different groups affect biological activity.
  • Enhance formulation stability in drug development, especially with complex structures like this one.

As a student or scientist, diving into the chemistry of this compound opens up pathways to explore innovative solutions to pressing medicinal challenges. The ability to design and manipulate chemical structures like 2-hydroxy-N-(2-hydroxy-2-phenyl-ethyl)-3-isopropyl-6-methyl-benzamide is a powerful tool in the ongoing quest for improved pharmaceuticals.

Synonyms
3-Hydroxy-N-(beta-hydroxyphenethyl)-p-cymene-2-carboxamide
2015-54-5
BRN 2818166
p-CYMENE-2-CARBOXAMIDE, 3-HYDROXY-N-(beta-HYDROXYPHENETHYL)-
DTXSID80942196
2-Hydroxy-N-(2-hydroxy-2-phenylethyl)-6-methyl-3-(propan-2-yl)benzene-1-carboximidic acid