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Isopropylmethylsalicylamide

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Identification
Molecular formula
C13H19NO3
CAS number
55492-58-7
IUPAC name
2-hydroxy-N-(2-hydroxyethyl)-3-isopropyl-6-methyl-benzamide
State
State

At room temperature, Isopropylmethylsalicylamide is in a solid state. Its crystalline structure makes it stable under normal environmental conditions, with no special precautions needed for storage unless in extreme conditions.

Melting point (Celsius)
113.50
Melting point (Kelvin)
386.65
Boiling point (Celsius)
391.30
Boiling point (Kelvin)
664.45
General information
Molecular weight
223.29g/mol
Molar mass
223.2940g/mol
Density
1.1374g/cm3
Appearence

Isopropylmethylsalicylamide appears as a crystalline solid. It is typically white to off-white in color and can sometimes exhibit a slightly yellow hue depending on the level of impurities present. The texture is usually smooth to the touch.

Comment on solubility

Solubility of 2-hydroxy-N-(2-hydroxyethyl)-3-isopropyl-6-methyl-benzamide

The solubility of 2-hydroxy-N-(2-hydroxyethyl)-3-isopropyl-6-methyl-benzamide can be influenced by several factors including its chemical structure and intermolecular interactions. Understanding its solubility characteristics can be crucial for various applications such as drug formulation and environmental chemistry. Here are some key points regarding its solubility:

  • Polarity: The presence of hydroxyl groups (-OH) suggests that the compound may exhibit hydrophilic characteristics, potentially increasing its solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds can enhance solubility. The two hydroxyl groups in the structure are likely to participate in hydrogen bonding, promoting greater solubility in aqueous solutions.
  • Hydrocarbon Chains: The isopropyl and methyl groups contribute to the compound's hydrophobic character, which might decrease solubility in highly polar solvents.
  • pH Dependence: The solubility may also depend on the pH of the solution. For example, the ionization of the amide functional group could vary, impacting overall solubility in different pH environments.

In summary, while the exact solubility of 2-hydroxy-N-(2-hydroxyethyl)-3-isopropyl-6-methyl-benzamide would require experimental data for precise quantification, its structure suggests that it may be moderately soluble in water, with solubility likely influenced by factors such as temperature and solvent polarity.

Interesting facts

Interesting Facts about 2-hydroxy-N-(2-hydroxyethyl)-3-isopropyl-6-methyl-benzamide

The compound 2-hydroxy-N-(2-hydroxyethyl)-3-isopropyl-6-methyl-benzamide is a remarkable chemical that finds its utility in various fields, particularly in the realm of pharmaceuticals. Here are some intriguing aspects of this compound:

  • Structural Complexity: This compound features a complex structure that includes multiple functional groups such as hydroxyl groups and an amide link. This intricate arrangement contributes to its unique chemical properties and reactivity.
  • Potential Applications: Due to its functional groups, this compound is of interest in medicinal chemistry. It may have applications as a drug candidate, potentially influencing various biological pathways.
  • Hydrophilic Character: The presence of hydroxyl groups enhances the compound's hydrophilicity, which can improve its solubility in biological systems. This property is particularly advantageous for drugs aiming to target specific sites in the body.
  • Role of Isopropyl Group: The isopropyl moiety contributes to the compound's lipophilicity. This balance between hydrophilicity and lipophilicity is crucial for the compound's bioavailability and pharmacokinetic properties.
  • Research Endeavors: Scientific studies often examine derivatives of this compound to understand their biological activities and therapeutic potential. Ongoing research may unveil new functionalities or enhancements in efficacy.

In summary, 2-hydroxy-N-(2-hydroxyethyl)-3-isopropyl-6-methyl-benzamide is a compound that exemplifies the complexity and beauty of organic chemistry. Its intriguing functionality and potential applications make it a subject of ongoing discussion among chemists and pharmacologists alike.

Synonyms
BRN 2619274
p-CYMENE-2-CARBOXAMIDE, 3-HYDROXY-N-(2-HYDROXYETHYL)-
3864-38-8
N-(2-Hydroxyethyl)-3-isopropyl-4-methylsalicylamide
Salicylamide, N-(2-hydroxyethyl)-3-isopropyl-4-methyl-
DTXSID90191951
(2'-Ossietil)amide dell' acido 2-ossi-6-metil-3-isopropilbenzoico [Italian]
(2'-Ossietil)amide dell' acido 2-ossi-6-metil-3-isopropilbenzoico
DTXCID30114442