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Pirfenidone

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Identification
Molecular formula
C12H11NO2
CAS number
53179-13-8
IUPAC name
2-hydroxy-N-(4-methyl-2-pyridyl)-2-phenyl-acetamide
State
State

At room temperature, pirfenidone is typically in a solid state.

Melting point (Celsius)
109.00
Melting point (Kelvin)
382.15
Boiling point (Celsius)
492.40
Boiling point (Kelvin)
765.60
General information
Molecular weight
185.22g/mol
Molar mass
185.2210g/mol
Density
1.2134g/cm3
Appearence

Pirfenidone is a white to pale yellow crystalline powder.

Comment on solubility

Solubility of 2-hydroxy-N-(4-methyl-2-pyridyl)-2-phenyl-acetamide

The solubility of 2-hydroxy-N-(4-methyl-2-pyridyl)-2-phenyl-acetamide presents some intriguing characteristics. As a chemical compound featuring both polar and non-polar functional groups, its solubility will largely depend on the solvent used. Here are some key points to consider:

  • Polar solvents: This compound may exhibit reasonable solubility in polar solvents like water and alcohol due to the presence of the hydroxyl group (-OH) which can form hydrogen bonds.
  • Non-polar solvents: Conversely, its aromatic groups contribute to hydrophobic interactions, suggesting lower solubility in non-polar solvents such as hexane or benzene.
  • pH sensitivity: The solubility can also be influenced by the pH of the solution. At different pH levels, the ionization of the amide and hydroxyl groups may alter its solubility characteristics.
  • Temperature effects: Higher temperatures could enhance solubility in certain solvents by increasing molecular motion and reducing intermolecular forces.

In conclusion, while the solubility of 2-hydroxy-N-(4-methyl-2-pyridyl)-2-phenyl-acetamide can vary widely, the combination of polar and non-polar functional groups creates a complex balance that requires careful consideration of both solvents and environmental conditions for optimal dissolution.

Interesting facts

Interesting Facts about 2-hydroxy-N-(4-methyl-2-pyridyl)-2-phenyl-acetamide

This intriguing compound, known for its complex molecular structure, is often highlighted in the realm of medicinal chemistry. Here are some key points regarding its significance and applications:

  • Pharmacological Potential: 2-hydroxy-N-(4-methyl-2-pyridyl)-2-phenyl-acetamide has shown promise in various pharmacological studies. Its unique structure allows it to interact with biological systems in potentially therapeutic ways.
  • Mechanism of Action: The compound is thought to function through multiple mechanisms, which may include enzyme inhibition or receptor modulation. This makes it an interesting subject for researchers focused on developing new drugs.
  • Research Interest: Due to its pyridyl ring, this molecule attracts attention in scientific research. Pyridine derivatives are often associated with a variety of biological activities, increasing the compound's relevance in drug discovery.
  • Versatile Synthesis: The synthesis of this compound showcases the ingenuity of organic chemistry. Various methods can be employed to create it, making it a valuable example for students studying organic synthesis techniques.

As the field of medicinal chemistry continues to evolve, compounds like 2-hydroxy-N-(4-methyl-2-pyridyl)-2-phenyl-acetamide represent both the challenges and the opportunities that lie ahead in drug development. Every new discovery can contribute to a greater understanding of how chemical compounds can impact health and disease.


By studying such compounds, scientists not only enhance their knowledge of chemistry but also improve their ability to contribute to innovations in healthcare and treatment options.