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Rabeprazole

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Identification
Molecular formula
C18H21N3O3S
CAS number
117976-89-2
IUPAC name
2-hydroxy-N-(5-methyl-2-pyridyl)-2-phenyl-acetamide
State
State

At room temperature, Rabeprazole is a solid. It is often handled in powder form which facilitates its use in pharmaceutical preparations, particularly as an anti-ulcer medication.

Melting point (Celsius)
145.50
Melting point (Kelvin)
418.65
Boiling point (Celsius)
460.00
Boiling point (Kelvin)
733.15
General information
Molecular weight
359.45g/mol
Molar mass
359.3790g/mol
Density
1.3560g/cm3
Appearence

Rabeprazole typically appears as a white to pale yellow crystalline powder that is odourless. The appearance can vary slightly depending on the purity and the specific conditions of storage, but it generally maintains these characteristics.

Comment on solubility

Solubility of 2-hydroxy-N-(5-methyl-2-pyridyl)-2-phenyl-acetamide

The solubility of 2-hydroxy-N-(5-methyl-2-pyridyl)-2-phenyl-acetamide is influenced by several factors, making it a fascinating compound to study. Here are some key points regarding its solubility:

  • Polarity: The presence of both hydroxy and acetamide functional groups contributes to the molecule's polarity, which generally enhances its interaction with polar solvents such as water.
  • Temperature: Solubility can significantly increase with temperature. As temperature rises, the kinetic energy of molecules increases, promoting better dissolution.
  • Solvent Selection: While it is likely to be soluble in polar solvents, its solubility in non-polar solvents may be limited due to the hydrophobic character of the phenyl group.

In summary, the solubility of 2-hydroxy-N-(5-methyl-2-pyridyl)-2-phenyl-acetamide is characterized by its dual functionality and structural components. As a result, it exhibits varying degrees of solubility depending on the nature of the solvent and external conditions.

Interesting facts

Interesting Facts about 2-hydroxy-N-(5-methyl-2-pyridyl)-2-phenyl-acetamide

2-hydroxy-N-(5-methyl-2-pyridyl)-2-phenyl-acetamide, commonly studied for its potential biological activities, showcases a fascinating blend of organic chemistry and medicinal applications. Here are some engaging insights about this compound:

  • Pharmacological Interest: This compound is primarily explored for its therapeutic potential, notably in the areas of pain management and anti-inflammatory effects. Its structural configuration allows for interactions with various biological targets, making it a candidate for drug development.
  • Structural Features: The unique combination of a hydroxyl group and a pyridine ring in its structure contributes to its reactivity and solubility properties, which are pivotal in biological systems. The presence of multiple aromatic rings enhances its stability and interaction potential.
  • Research Applications: Ongoing studies investigate its efficacy in treating conditions like arthritis and other inflammatory diseases. Researchers are keen to understand how its dual functional groups (hydroxyl and amide) play a role in modulating biological responses.
  • Synthesis Pathways: The synthesis of this compound typically involves strategic organic reactions, including amination and acylation processes. These pathways are essential for delivering high yields and purities necessary for scientific research.
  • Analytical Techniques: To study this compound comprehensively, scientists often employ techniques such as NMR spectroscopy, mass spectrometry, and X-ray crystallography. These tools help unravel the conformational dynamics of the molecule in various environments.

As science continues to explore the depths of chemical compounds like 2-hydroxy-N-(5-methyl-2-pyridyl)-2-phenyl-acetamide, we find ourselves at the intersection of chemistry and medicine, showcasing the importance of understanding molecular interactions in developing effective therapies. As one researcher aptly put it, "Every compound tells a story; it's our job to decode it."