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Salicylanilide

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Identification
Molecular formula
C13H11NO2
CAS number
87-17-2
IUPAC name
2-hydroxy-N-phenyl-benzamide
State
State

At room temperature, salicylanilide is in a solid state, commonly found as a crystalline powder.

Melting point (Celsius)
136.00
Melting point (Kelvin)
409.15
Boiling point (Celsius)
411.00
Boiling point (Kelvin)
684.15
General information
Molecular weight
213.23g/mol
Molar mass
213.2310g/mol
Density
1.3710g/cm3
Appearence

Salicylanilide typically appears as a white to off-white crystalline powder. It is commonly used in various applications, including as an antimicrobial agent in soaps and other formulations.

Comment on solubility

Solubility of 2-hydroxy-N-phenyl-benzamide

The solubility of 2-hydroxy-N-phenyl-benzamide in various solvents can exhibit interesting characteristics. This compound, which is a type of amide, can interact with different solvents based on its molecular structure.

Here are some key points regarding its solubility:

  • Polarity: The presence of the hydroxyl group (-OH) contributes to hydrogen bonding, enhancing solubility in polar solvents like water.
  • Non-polar Solvents: While it may have some solubility in non-polar solvents due to the phenyl group, its overall solubility would generally be lower compared to polar solvents.
  • Organic Solvents: It is expected to demonstrate good solubility in organic solvents such as ethanol and methanol, which can solvate the polar interactions from the amide and hydroxyl groups.

As a result, the solubility of 2-hydroxy-N-phenyl-benzamide can be summarized as:

  1. Highly soluble: in polar solvents (e.g., water, ethanol).
  2. Moderately soluble: in some organic solvents.
  3. Lower solubility: in non-polar solvents.

Understanding these solubility characteristics is crucial for applications in pharmaceuticals and organic synthesis, where solubility can greatly influence reactivity and bioavailability.

Interesting facts

Interesting Facts about 2-Hydroxy-N-phenyl-benzamide

2-Hydroxy-N-phenyl-benzamide, commonly known for its role in synthetic chemistry, has garnered attention due to its diverse applications and intriguing properties. Here are some notable aspects of this compound:

  • Versatile Chemical Intermediate: This compound serves as a versatile intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its structure enables modifications that allow for the development of new derivates with tailored functionalities.
  • Pharmaceutical Applications: Compounds similar to 2-hydroxy-N-phenyl-benzamide are often evaluated for their biological activities. They have potential anti-inflammatory and analgesic properties, making them of interest in medicinal chemistry.
  • Hydrogen Bonding Capacity: The presence of the hydroxyl group allows for strong hydrogen bonding, which can influence solubility and reactivity. This can be critical in determining how the compound behaves in various chemical environments.
  • Research Interest: There is ongoing research into the various derivatives of this compound to better understand how modifications affect their biological efficacy. Such inquiries can lead to novel therapeutic agents.

In the words of chemists: "The ability to modify simple aromatic compounds like 2-hydroxy-N-phenyl-benzamide opens pathways to innovative chemical research." It illustrates the beauty of organic chemistry, where small changes can lead to significant advancements in technology and medicine.

In conclusion, 2-hydroxy-N-phenyl-benzamide exemplifies the interconnectedness of chemistry and biology, showcasing how fundamental compounds can lead to important breakthroughs in human health and agriculture.

Synonyms
SALICYLANILIDE
87-17-2
2-Hydroxy-N-phenylbenzamide
N-Phenylsalicylamide
Salinide
Salinidol
Salicylanilid
Benzamide, 2-hydroxy-N-phenyl-
Salifebrin
Ansadol
Salnide
Salicylic acid anilide
Aseptolan
Hyanilid
o-Hydroxybenzanilide
Shirlan Extra
2-Hydroxybenzanilide
Sherstat SLN
Shirlan AG
Shirlan
2-N-Phenylcarboxamidophenol
Caswell No. 730
Anilid kyseliny salicylove
Salicylanilide [NF]
MFCD00002212
NSC 14881
WR 10019
Anilid kyseliny salicylove [Czech]
EINECS 201-727-8
LHP8NEY345
2-Hydroxy-N-phenyl-benzamide
EPA Pesticide Chemical Code 077407
BRN 1108135
DTXSID7021784
AI3-08114
CHEBI:239133
NSC-14881
SALICYLANILIDE [MI]
DTXCID501784
SALICYLANILIDE [WHO-DD]
ASK
4-12-00-00906 (Beilstein Handbook Reference)
Shirlan (VAN)
UNII-LHP8NEY345
oHydroxybenzanilide
NPhenylsalicylamide
Salicylanilide, 98%
SpecPlus_000935
2NPhenylcarboxamidophenol
WLN: QR BVMR
Spectrum5_000937
CBMicro_016731
2-Phenylaminocarbonylphenol
Benzamide, 2hydroxyNphenyl
Cambridge id 5305868
Oprea1_853375
MLS000105638
CHEMBL82970
DivK1c_007031
SCHEMBL152221
SCHEMBL14051034
KBio1_001975
2-Hydroxy-N-phenylbenzamide (1)
BDBM234300
HMS2091A21
HMS2401B23
HMS3652N07
Pharmakon1600-00300618
AAA08717
CCG-5616
HY-B1408
NSC14881
Tox21_301301
NSC755836
s4187
STL477629
AKOS000119673
CS-7965
NSC-755836
CAS-87-17-2
NCGC00076924-01
NCGC00076924-03
NCGC00257535-01
BS-18197
SMR000102616
SY048264
BIM-0016643.P001
SBI-0016643.P004
NS00008110
S0007
SW219188-1
EN300-18540
C18915
D78245
AB00053159_10
AB00053159_11
Q3469751
BRD-K83036479-001-04-3
BRD-K83036479-001-08-4
BRD-K83036479-001-09-2
Z68084595
201-727-8
SLI