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2-Hydroxybenzoic acid

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Identification
Molecular formula
C7H6O3
CAS number
69-72-7
IUPAC name
2-hydroxybenzoic acid;quinuclidin-3-yl acetate
State
State

At room temperature, 2-hydroxybenzoic acid is a solid. It is usually found in a crystalline form.

Melting point (Celsius)
158.60
Melting point (Kelvin)
431.80
Boiling point (Celsius)
211.00
Boiling point (Kelvin)
484.15
General information
Molecular weight
138.12g/mol
Molar mass
138.1210g/mol
Density
1.4430g/cm3
Appearence

2-Hydroxybenzoic acid, commonly known as salicylic acid, is a colorless to white crystalline solid. It is often available as a fine powder or in crystalline form. The compound has a sweetish odor when pure.

Comment on solubility

Solubility of 2-Hydroxybenzoic Acid and Quinuclidin-3-yl Acetate

Understanding the solubility of chemical compounds is crucial in the field of chemistry, particularly in applications like pharmaceuticals and materials science. The solubility of 2-hydroxybenzoic acid (C7H6O3), commonly known as salicylic acid, is influenced by several factors:

  • Polarity: This compound is polar due to the presence of hydroxyl (-OH) and carboxylic acid (-COOH) groups, enhancing its solubility in polar solvents such as water.
  • pH Level: The solubility increases in acidic solutions as the carboxylic group can remain protonated, but in alkaline conditions, it can dissociate, which may result in higher solubility.

On the other hand, quinuclidin-3-yl acetate (C10H15NO2), an ester derived from quinuclidine, exhibits different solubility characteristics:

  • Solvent Compatibility: It is more soluble in organic solvents like ethanol and acetone due to its non-polar ester group.
  • Limited Water Solubility: The presence of the bulky quinuclidine moiety restricts its solubility in water.

In summary, the solubility profiles of these two compounds highlight the significance of molecular structure on interaction with solvents. As noted, solubility can be influenced by:

  • Functional groups present
  • Environmental pH
  • Type of solvent used

Each of these factors plays a pivotal role in determining how compounds behave in various chemical environments, making their study essential for practical applications.

Interesting facts

Interesting Facts about 2-Hydroxybenzoic Acid and Quinuclidin-3-yl Acetate

2-Hydroxybenzoic Acid (Salicylic Acid)

2-Hydroxybenzoic acid, commonly known as salicylic acid, is a fascinating compound with a rich history in the field of medicinal chemistry. Here are some interesting facts:

  • Origin of Name: The name salicylic is derived from the Latin word salix, meaning willow tree, as it was originally isolated from willow bark.
  • Historical Significance: Salicylic acid has been used for centuries, notably as a pain-reliever and anti-inflammatory agent, paving the way for the development of its ester, acetylsalicylic acid, known as aspirin.
  • Mechanism of Action: It works by inhibiting the enzyme cyclooxygenase (COX), thus reducing the production of inflammatory substances, making it effective in treating pain and inflammation.
  • Skin Care: In contemporary products, it is widely used in dermatology for treating acne due to its ability to penetrate pores and exfoliate the skin.

Quinuclidin-3-yl Acetate

Quinuclidin-3-yl acetate is an interesting compound with significant relevance in pharmacology. Here’s what makes it noteworthy:

  • Cholinergic Activity: This compound exhibits strong cholinergic activity, meaning it mimics the action of the neurotransmitter acetylcholine, making it valuable in research related to cognitive function and neuropharmacology.
  • Synthetic Utility: Quinuclidin-3-yl acetate serves as an important synthetic intermediate in the production of various drugs, particularly those targeting the nervous system.
  • Potential Applications: Ongoing studies suggest that this compound may have potential applications in developing treatments for conditions like Alzheimer’s disease and other cognitive impairments.
  • Research Substance: As a versatile compound, it’s of interest not just to medicinal chemists, but also to neuroscientists studying the cholinergic system.

Conclusion

Both 2-hydroxybenzoic acid and quinuclidin-3-yl acetate are remarkable compounds, each boasting unique properties and applications that continue to inspire research and development in chemistry and medicine. Their rich histories and varying uses highlight the importance of understanding chemical compounds in advancing health and science.

Synonyms
ACECLIDINE SALICYLATE
6821-59-6
Aceclydine salicylate
3-Acetoxyquinuclidine salicylate
UNII-MCC2GG434J
MCC2GG434J
3-Quinuclidinol, acetate (ester), salicylate
2-HYDROXYBENZOIC ACID-1-AZABICYCLO(2.2.2)OCT-3-YL ACETATE (1:1)
684-851-9
1-azabicyclo[2.2.2]octan-3-yl acetate;2-hydroxybenzoic acid
(4s)-quinuclidin-3-yl acetate 2-hydroxybenzoate
2-hydroxybenzoic acid - 1-azabicyclo[2.2.2]oct-3-yl acetate (1:1)
2-HYDROXYBENZOIC ACID - 1-AZABICYCLO(2.2.2)OCT-3-YL ACETATE (1:1)
DTXSID90987715
DL-3-acetoxyquinuclidine salicylate
GAA82159
STK064146
AKOS005388635
Quinuclidin-3-yl acetate 2-hydroxybenzoate
Aceclidine DL-3-acetoxyquinuclidine salicylate
Q27283857
2-Hydroxybenzoic acid--1-azabicyclo[2.2.2]octan-3-yl acetate (1/1)