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Salicylonitrile

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Identification
Molecular formula
C7H5NO
CAS number
611-20-1
IUPAC name
2-hydroxybenzonitrile
State
State

At room temperature, salicylonitrile is in a solid crystalline state.

Melting point (Celsius)
37.00
Melting point (Kelvin)
310.15
Boiling point (Celsius)
282.00
Boiling point (Kelvin)
555.15
General information
Molecular weight
119.12g/mol
Molar mass
119.1240g/mol
Density
1.1800g/cm3
Appearence

Salicylonitrile appears as white to off-white crystals or crystalline powder. It has a slightly aromatic odor and is generally found in a solid state at room temperature.

Comment on solubility

Solubility of 2-hydroxybenzonitrile

2-hydroxybenzonitrile, often referred to as salicylonitrile, exhibits intriguing solubility properties that make it a compound of interest in various applications. Its chemical formula is C7H5NO, and it is characterized by the presence of both a hydroxyl group (-OH) and a nitrile group (-C≡N).

The solubility characteristics of 2-hydroxybenzonitrile are influenced by its functional groups:

  • Water Solubility: 2-hydroxybenzonitrile shows moderate solubility in water due to hydrogen bonding capability of the hydroxyl group.
  • Organic Solvents: It is more soluble in organic solvents such as ethanol, methanol, and dichloromethane, which can help in various extraction and synthesis processes.
  • Temperature Dependence: Like many organic compounds, its solubility can increase with temperature, making it easier to dissolve in solutions at higher temperatures.

In conclusion, 2-hydroxybenzonitrile's solubility reflects a balance between hydrophilic and hydrophobic interactions, demonstrating the complexity of solvation in organic compounds. This solubility profile plays a crucial role in its applications in chemical synthesis and as a building block in pharmaceuticals.

Interesting facts

Interesting Facts about 2-Hydroxybenzonitrile

2-Hydroxybenzonitrile, commonly known as o-hydroxybenzonitrile, is a fascinating compound with various applications and properties that make it stand out in the world of organic chemistry. Here are some noteworthy aspects:

  • Structure and Functional Groups: 2-Hydroxybenzonitrile is characterized by a hydroxyl (-OH) group and a nitrile (-CN) group attached to a benzene ring. This combination leads to unique reactivity and solubility characteristics.
  • Reactivity: The presence of both the hydroxyl and nitrile groups can facilitate a variety of chemical reactions, including nucleophilic substitutions and condensation reactions. This makes it a valuable intermediate in synthetic organic chemistry.
  • Applications: This compound plays an important role in the synthesis of pharmaceuticals, agrochemicals, and dyes. Specifically, compounds containing a hydroxyl group can exhibit increased biological activity and solubility in biological systems.
  • Analytical Use: Due to its distinctive spectral properties, 2-hydroxybenzonitrile can be utilized as a reference compound in UV-Vis spectroscopy. Its ability to form hydrogen bonds can also affect its spectral characteristics, providing insights into molecular interactions.
  • Potential in Research: Researchers have been exploring the biological activity of 2-hydroxybenzonitrile and its derivatives. Studies suggest it may have potential applications in medicinal chemistry, where its unique functional groups can lead to novel drug candidates.

As we continue to explore the vast frontier of organic chemistry, compounds like 2-hydroxybenzonitrile inspire curiosity and challenge our understanding of chemical interactions. Its multifunctional nature demonstrates the intricate balance between structure and reactivity in organic compounds, leading to exciting possibilities for innovation.

Synonyms
2-Hydroxybenzonitrile
2-Cyanophenol
611-20-1
Salicylonitrile
o-Hydroxybenzonitrile
Salicylnitrile
Benzonitrile, 2-hydroxy-
Benzonitrile, o-hydroxy-
o-Hydoxybenzonitrile
51RSM8K1VZ
NSC 53558
DTXSID3041661
EINECS 210-259-3
NSC-53558
DTXCID1021661
EC 210-259-3
210-259-3
inchi=1/c7h5no/c8-5-6-3-1-2-4-7(6)9/h1-4,9
o-Cyanophenol
Benzonitrile, hydroxy-
2-Hydroxy-benzonitrile
Hydroxybenzonitrile
69481-42-1
2-hydroxy benzonitrile
MFCD00002145
UNII-51RSM8K1VZ
orthocyanophenol
cyano-phenol
2-cyano phenol
o-hydroxybenzonitril
0R0
2-Cyanophenol; 2-Hydroxybenzonitrile; NSC 53558; Salicylnitrile; o-Cyanophenol; o-Hydroxybenzonitrile
NSC53558
Hydroxy Benzonitrile
CYANOPHENOL
2-hydroxy-benzonitril
2-hydroxylbenzonitrile
2-hydroxyphenyl cyanide
Bunitrolol Intermediates
SCHEMBL5756
2-Hydroxybenzonitrile, 99%
CHEMBL195342
benzenecarbonitrile, 2-hydroxy-
BDBM36298
CHEBI:194657
o-Cyanophenol;2-Hydroxybenzonitrile
STR01814
Tox21_302110
STK067741
AKOS000120269
AC-3142
CCG-302494
CS-W013585
FC54821
HY-W012869
NCGC00255417-01
NCGC00340789-01
CAS-611-20-1
DB-030214
NS00007735
EN300-20326
AB01333378-02
Q27260915
F0001-1605
Z104477750