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Isothionic acid

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Identification
Molecular formula
C2H6O4S
CAS number
107-36-8
IUPAC name
2-hydroxyethanesulfonic acid
State
State

At room temperature, isothionic acid is found in a solid state

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
110.13g/mol
Molar mass
110.1130g/mol
Density
1.6220g/cm3
Appearence

Isothionic acid typically appears as a colorless solid or a clear, colorless solution when dissolved in water.

Comment on solubility

Solubility of 2-hydroxyethanesulfonic acid

2-hydroxyethanesulfonic acid, often abbreviated as HEPES, is notable for its solubility characteristics which play a critical role in various biochemical applications. Here are some key points regarding its solubility:

  • Water Solubility: HEPES is highly soluble in water, which makes it an excellent buffer component in biological and biochemical experiments.
  • Solvent Interaction: The solubility of HEPES is primarily due to its zwitterionic nature, where it contains both positive and negative charges that interact favorably with water molecules.
  • pH Sensitivity: The solubility can vary with pH changes; it is most effective in maintaining pH stability around 6.8 to 8.2.
  • Temperature Effects: Increased temperatures generally enhance solubility, which is an important consideration when preparing solutions for experiments.

In summary, the solubility of 2-hydroxyethanesulfonic acid in water and its behavior under varying conditions make it a versatile compound, often highlighted in biochemical research for its buffering capacity and stability. Its ability to maintain physiological pH ranges underlines its significance in cell culture and other laboratory applications.

Interesting facts

Interesting Facts about 2-Hydroxyethanesulfonic Acid

2-Hydroxyethanesulfonic acid, commonly known as tromethamine sulfonic acid or HEPES, is a remarkable compound widely utilized in biochemical research and laboratory applications. Here are some fascinating insights into this versatile compound:

  • Buffering Agent: HEPES serves as an excellent biological buffer, maintaining the pH stability in various biochemical assays and cell culture environments.
  • Physiological Relevance: Its ability to mimic physiological conditions makes it suitable for experiments that must closely resemble in vivo environments.
  • Cell Culture: It is particularly favored in cell culture media to ensure optimal growth conditions for eukaryotic cells.
  • Compatibility: HEPES is compatible with a wide range of biological systems and is often used in combination with other reagents without compromising cell viability.
  • Non-toxic: One of the standout characteristics of 2-hydroxyethanesulfonic acid is its minimal toxicity, which allows researchers to use it at higher concentrations compared to traditional buffers without damaging cells.

In the words of a researcher, HEPES is one of those unsung heroes in the lab that quietly ensures our experiments have a fighting chance at success. Its multifunctional uses extend beyond basic research, touching areas such as drug delivery and protein purification. Well-regarded in both academia and industry, 2-hydroxyethanesulfonic acid continues to be a staple in the toolkit of scientists worldwide.

In summary, 2-hydroxyethanesulfonic acid is not just a chemical compound; it’s an essential player in advancing our understanding of biological processes. Its remarkable properties ensure that it remains a key component in numerous scientific innovations.

Synonyms
ISETHIONIC ACID
107-36-8
2-Hydroxyethanesulfonic acid
2-Hydroxyethanesulphonic acid
2-Hydroxyethane-1-sulfonic acid
Hydroxyethylsulfonic acid
Ethanesulfonic acid, 2-hydroxy-
Ethanolsulfonic acid
Isethionate
Caswell No. 502
(2-Hydroxyethyl)sulfonic acid
Kyselina isethionova
USAF DO-14
Kyselina isethionova [Czech]
2-Hydroxyethanesulfonate
2-hydroxyethylsulfonic acid
EPA Pesticide Chemical Code 047701
Ethanolsulfonate
BRN 1751214
Kyselina 2-hydroxyethansulfonova [Czech]
AI3-19644
EINECS 203-484-3
NSC 60516
Hydroxyethylsulfonate
Kyselina 2-hydroxyethansulfonova
UNII-97J3QN9884
2-Hydroxyethanesulphonate
NSC-60516
(2-Hydroxyethyl)sulfonate
Potassium isethionate
97J3QN9884
ISETHIONIC ACID [MI]
beta-hydroxyethanesulfonic acid
CHEBI:1157
21561-88-6
DTXSID1041427
4-04-00-00084 (Beilstein Handbook Reference)
2-hydroxyethane-1-sulfonate
Acid, Isethionic
NSC1898
2-Hydroxyethanesulfonic Acid (80% w/w in Water)
Acid, Hydroxyethylsulfonic
8X3
MFCD00242599
2-hydroxyethylsulfonate
b-Hydroxyethanesulfonate
2-hydroxyethylsulphonate
b-Hydroxyethanesulphonate
Hydroxyethanesulfonic acid
beta-Hydroxyethanesulfonate
SCHEMBL827
WLN: WSQ2Q
2-Hydroxyethanesulfonicacid
beta-Hydroxyethanesulphonate
bmse000242
bmse000819
B-hydroxyethanesulfonic acid
2-hydroxyethylsulphonic acid
b-Hydroxyethanesulphonic acid
2-oxidanylethanesulfonic acid
2-Hydroxyethane-1-sulphonate
beta-Hydroxyethanesulphonic acid
DTXCID9021427
Hydroxyethanesulfonic acid (HES)
2-Hydroxyethane-1-sulphonic acid
HY-Y0095
NSC60516
AC-538
AKOS006228878
CS-W019640
FH55327
AS-44331
PD040603
NS00008080
Isethionic acid pound 80% in water pound(c)
A10809
C05123
EN300-243452
Q339734
2-HYDROXYETHANESULPHONIC ACID (80% IN WATER)