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Promethazine

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Identification
Molecular formula
C17H20N2OS
CAS number
60-87-7
IUPAC name
2-hydroxyethyl-dimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium
State
State
Promethazine is usually found in a solid-state at room temperature, especially in its purified form. It is handled in laboratories and pharmaceutical environments as a powder or crystalline substance.
Melting point (Celsius)
60.00
Melting point (Kelvin)
333.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
284.42g/mol
Molar mass
284.4170g/mol
Density
1.1300g/cm3
Appearence

Promethazine appears as a white to faint yellow crystalline powder. It may have a slight odor and is typically provided in its hydrochloride salt form for medicinal uses. The powder is highly soluble in water, which is useful for preparing solutions for injection or oral consumption in liquid formulations.

Comment on solubility

Solubility of 2-hydroxyethyl-dimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium

The solubility of 2-hydroxyethyl-dimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium is influenced by various factors, reflecting its unique chemical structure and properties. Here are some key points to consider:

  • Polarity: The presence of hydroxyl (-OH) groups in the compound enhances its polarity, which may lead to better solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl group can participate in hydrogen bonding, increasing solubility in aqueous solutions.
  • Hydrophobic Character: The phenothiazine moiety introduces hydrophobic characteristics, which may affect solubility negatively in polar solvents.

As a result, the compound may exhibit:

  1. Good solubility in water due to its polar groups.
  2. Decreased solubility in non-polar solvents because of the hydrophobic regions.

Overall, it can be stated that while this compound is likely to be soluble in aqueous environments, the balance between its polar and non-polar characteristics can lead to variability based on solvent choice. To quote a common insight into solubility: "Like dissolves like." Thus, understanding its solubility behavior requires a consideration of both its structural components and the solvent environment.

Interesting facts

Exploring 2-Hydroxyethyl-dimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium

2-Hydroxyethyl-dimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium is an intriguing compound that blends organic chemistry with medical applications. This compound, often encountered in the field of pharmaceutical chemistry, features the phenothiazine structure, widely recognized for its use as antipsychotic agents. Here are some fascinating aspects of this compound:

  • Phenothiazine Derivatives: The presence of a phenothiazine moiety enhances the compatibility of the compound with biological systems, facilitating its role in drug formulation.
  • Dual Functionalities: The hydroxyethyl and dimethylammonium components contribute to the compound's unique properties, making it hydrophilic and potentially increasing solubility in biological media.
  • Therapeutic Applications: Compounds based on this structure are often investigated for use in therapies targeting mental health disorders. The mechanisms by which they act can lead to significant advances in treatment options.
  • Structural Innovation: The intricate design of this chemical allows for enhanced receptor activity, which can be crucial in the development of more effective pharmaceuticals.

Scientists might say, "Through the lens of chemistry, we can explore the profound impact of compounds like this one, shaping the future of medicine.” This compound exemplifies the blend of creativity and science that propels advancements in therapeutic agents. Whether in a laboratory setting or as part of a research initiative, understanding compounds like 2-hydroxyethyl-dimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)ammonium is vital for the progress in medicinal chemistry.

Synonyms
Promethazine hydroxyethyl
N-Hydroxyethylpromethazine
hydroxyethylpromethazine
UNII-571559SLAJ
AMMONIUM, (2-HYDROXYETHYL)DIMETHYL(1-METHYL-2-PHENOTHIAZIN-10-YLETHYL)-
(2-hydroxyethyl)dimethyl(1-(10H-phenothiazin-10-yl)propan-2-yl)azanium
(2-hydroxyethyl)dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]azanium
7647-63-4
2-hydroxyethyl-dimethyl-(1-phenothiazin-10-ylpropan-2-yl)azanium
571559SLAJ
SCHEMBL790774
CHEMBL3707371
DTXSID30871861
CHEBI:135995
DB13840
Q6676872
10H-Phenothiazine-10-ethanaminium, N-(2-hydroxyethyl)-N,N,alpha-trimethyl-
10H-PHENOTHIAZINE-10-ETHANAMINIUM, N-(2-HYDROXYETHYL)-N,N,.ALPHA.-TRIMETHYL-