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phthalimide

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Identification
Molecular formula
C8H5NO2
CAS number
85-41-6
IUPAC name
2-(hydroxymethyl)isoindoline-1,3-dione
State
State

Phthalimide is found in a solid state at room temperature. Its structure allows it to remain stable and unreactive under normal conditions, thus preserving its solid crystalline form unless subjected to heat over its melting point or dissolved in a suitable solvent.

Melting point (Celsius)
238.00
Melting point (Kelvin)
511.00
Boiling point (Celsius)
336.00
Boiling point (Kelvin)
609.00
General information
Molecular weight
147.13g/mol
Molar mass
147.1310g/mol
Density
1.5260g/cm3
Appearence

Phthalimide appears as a white to slightly yellowish crystalline solid. Its crystalline structure gives it a flaky texture resembling many solid organic compounds. It does not have any distinctive odor, which is typical for many imide compounds. It is soluble in organic solvents but has low solubility in water.

Comment on solubility

Solubility of 2-(hydroxymethyl)isoindoline-1,3-dione

The solubility of 2-(hydroxymethyl)isoindoline-1,3-dione in various solvents can reveal much about its chemical nature and potential applications. This compound is known for its interesting solubility properties, which can be highlighted as follows:

  • Water Solubility: Generally, compounds with hydroxymethyl groups tend to exhibit greater hydrophilicity, making 2-(hydroxymethyl)isoindoline-1,3-dione potentially soluble in water. However, the actual solubility may vary based on factors such as temperature and pH.
  • Organic Solvents: This compound may also dissolve well in polar organic solvents like ethanol or methanol, which can stabilize its molecular interactions.
  • Hydrophobicity: The isoindoline ring structure may introduce hydrophobic characteristics, affecting its overall solubility in nonpolar solvents.

In summary, the solubility of 2-(hydroxymethyl)isoindoline-1,3-dione is influenced by its functional groups and molecular structure. Experimental data is crucial to determine its precise solubility profile in various solvents, making it an intriguing subject for further research.

Interesting facts

Interesting Facts about 2-(Hydroxymethyl)isoindoline-1,3-dione

2-(Hydroxymethyl)isoindoline-1,3-dione, often referred to as a derivative of isoindoline, is a fascinating compound that showcases the intersection of organic chemistry and medicinal applications. Here are some captivating insights into this compound:

  • Structural Significance: The structure of 2-(hydroxymethyl)isoindoline-1,3-dione includes a unique bicyclic framework, which can exhibit both aromatic and non-aromatic properties. This structural feature can be crucial in influencing the compound's reactivity and interaction with biological systems.
  • Biological Relevance: Compounds related to isoindoline structures are often studied for their potential pharmacological properties. This particular compound has garnered attention due to its possible applications in drug development and therapeutic agents.
  • Versatile Synthesis: The synthesis of 2-(hydroxymethyl)isoindoline-1,3-dione can involve various methods, including cyclization reactions and modifications of existing isoindoline derivatives. These synthetic strategies allow chemists to explore analogs with enhanced biological activity.
  • Applications in Dyes: Given its vibrant profile, the molecule has potential applications in creating dyes and pigments. The inherent flexibility in chemical modifications lends itself to tailoring colors for specific uses in the textile and art industries.
  • Research Potential: The compound is still under investigation, encouraging scientists to delve deeper. Studies focus on its interaction with enzymes, receptors, and other cellular components to elucidate its mechanisms of action.

In summary, 2-(hydroxymethyl)isoindoline-1,3-dione represents a captivating example of how organic compounds can bridge diverse fields, from drug discovery to materials science. As ongoing research unfolds, this compound may reveal even more exciting possibilities in various applications.

Synonyms
N-(Hydroxymethyl)phthalimide
118-29-6
2-(hydroxymethyl)isoindoline-1,3-dione
N-Hydroxymethylphthalimide
Phthalimidomethyl alcohol
N-Methylolphthalimide
Phthalimidomethanol
Oxymethyl phthalimide
Hydroxymethylphthalimide
2-(Hydroxymethyl)-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 2-(hydroxymethyl)-
Methanol, phthalimido-
2-(hydroxymethyl)isoindole-1,3-dione
Oxymethylphthalimide
PHTHALIMIDE, N-(HYDROXYMETHYL)-
NSC 27350
N-hydroxymethyl phthalimide
EINECS 204-241-4
MFCD00005899
BRN 0140946
G8L8BA278J
DTXSID1026954
CHEBI:38816
AI3-28943
2-(hydroxymethyl)-2,3-dihydro-1H-isoindole-1,3-dione
NSC-27350
DTXCID506954
5-21-10-00366 (Beilstein Handbook Reference)
1H-Isoindole-1, 2-(hydroxymethyl)-
UNII-G8L8BA278J
(Hydroxymethyl)phthalimide
N-hydroxy methylphthalimide
N-hydroxymethyl-phthalimide
N-(Hydroxymethyl)phtalimide
N-(hydroxymethy) phthalimide
N-(hydroxymethyl)-phthalimide
SCHEMBL101555
N--(hydroxymethyl)-phthalimide
CHEMBL3183835
ALBB-017986
BCP27127
HY-Y0895
N-(Hydroxymethyl)phthalimide, 97%
NSC27350
NSC27471
NSC39723
STR02558
Tox21_200859
2-Hydroxymethyl-isoindole-1,3-dione
NSC-27471
NSC-39723
STK028674
AKOS000269457
FH33638
SB66110
2-(hydroxymethyl)-1,3-isoindolinedione
2-(hydroxymethyl)-isoindole-1,3-dione
NCGC00248852-01
NCGC00258413-01
PIMOH (N-Hydroxymethyl phthalimide acid
AC-19446
CAS-118-29-6
CS-0015898
H0648
NS00023806
EN300-17143
D70499
H60031
2-(Hydroxymethyl)-1H-isoindole-1,3(2H)-dione #
Q27117985
F0777-0575
204-241-4