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Identification
Molecular formula
C3H8O4S
CAS number
526-96-7
IUPAC name
2-hydroxypropane-2-sulfonic acid
State
State

2-Hydroxypropane-2-sulfonic acid is a solid at room temperature. It is generally marketed in a crystalline white powder form, which maintains its stability under standard conditions.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
124.14g/mol
Molar mass
124.1370g/mol
Density
1.7340g/cm3
Appearence

2-Hydroxypropane-2-sulfonic acid generally appears as a white crystalline powder. These crystals are fine and uniform, and the compound is known to be highly soluble in water, creating a clear solution.

Comment on solubility

Solubility of 2-Hydroxypropane-2-sulfonic Acid

2-Hydroxypropane-2-sulfonic acid, often referred to as tromethamine sulfonic acid, exhibits notable solubility characteristics that make it valuable in various applications. Here are some key points regarding its solubility:

  • Highly Soluble in Water: Due to the presence of a sulfonic acid group and a hydroxyl group, this compound is easily soluble in water, making it ideal for aqueous solutions.
  • Polar Nature: The polar functional groups contribute to its strong interactions with water molecules, enhancing its solubility. These interactions include hydrogen bonding and ionic interactions.
  • Influence of pH: The solubility can be influenced by the pH of the solution, where more acidic conditions may further enhance its solubility by maintaining the acid form stable.
  • Miscibility with Other Solvents: In addition to water, 2-hydroxypropane-2-sulfonic acid may show variable solubility in organic solvents, though it is primarily designed for use in aqueous solutions.

In summary, the solubility profile of 2-hydroxypropane-2-sulfonic acid underscores its importance in biochemical and pharmaceutical applications. Its ability to dissolve readily in water makes it a key player in many formulations and reactions.

Interesting facts

Interesting Facts about 2-Hydroxypropane-2-sulfonic Acid

2-Hydroxypropane-2-sulfonic acid, commonly known as tromethamine sulfonic acid, is a compound that holds significant importance in various scientific fields. Here are some intriguing aspects of this versatile molecule:

  • Biological Buffer: One of the primary uses of 2-hydroxypropane-2-sulfonic acid is as a biological buffer. Its ability to maintain a stable pH in biological systems makes it invaluable in many laboratory and clinical settings.
  • Pharmaceutical Applications: This compound is often incorporated in drug formulations to enhance solubility and stability. Its compatibility with active pharmaceutical ingredients is crucial for ensuring drug efficacy.
  • Environmental Relevance: The compound's unique structure allows it to interact suitably in various chemical processes, which can have implications in environmental chemistry and pollutant management.
  • Research Utilization: Scientists utilize this compound in various fields, including biochemistry and molecular biology, to explore enzyme kinetics and protein stability under varying pH conditions.
  • Safety Profile: Generally regarded as safe, 2-hydroxypropane-2-sulfonic acid has a low toxicity profile, making it suitable for applications in sensitive biological contexts.

As stated by chemists in the field, “The unique buffering capacity of 2-hydroxypropane-2-sulfonic acid makes it an essential tool in the toolkit of any biochemical researcher.”
Its distinctive properties not only bolster laboratory studies but also influence pharmaceutical development, making 2-hydroxypropane-2-sulfonic acid a compound of great interest and relevance in contemporary science.

Synonyms
2-Propanesulfonic acid, 2-hydroxy-
7785-42-4
EINECS 232-079-4
DTXSID9064845
DTXCID1048049
NSC7598
NSC26211
2-hydroxypropane-2-sulfonic acid
2-Hydroxy-2-propanesulfonic acid
2-Hydroxypropane-2-sulphonic acid
SCHEMBL645048
2-Hydroxy-2-propane-sulfonate
WCBWZBSYSCYPTM-UHFFFAOYSA-N
NS00080810