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2-Hydroxypropyl stearate

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Identification
Molecular formula
C21H42O3
CAS number
22464-99-9
IUPAC name
2-hydroxypropyl octadecanoate
State
State

At room temperature, 2-hydroxypropyl stearate is a solid. It is typically waxy in consistency, making it suitable for use in various industrial and cosmetic applications.

Melting point (Celsius)
37.00
Melting point (Kelvin)
310.15
Boiling point (Celsius)
499.00
Boiling point (Kelvin)
772.00
General information
Molecular weight
356.58g/mol
Molar mass
356.5770g/mol
Density
0.9000g/cm3
Appearence

2-Hydroxypropyl stearate appears as a white to off-white waxy solid. It may also be found in pellet or flake form and has a characteristic fatty odor. This compound is often used as an emollient or thickening agent in cosmetic formulations.

Comment on solubility

Solubility of 2-hydroxypropyl octadecanoate

2-hydroxypropyl octadecanoate, a compound derived from the esterification of octadecanoic acid and propylene glycol, exhibits unique solubility characteristics. Understanding its solubility is crucial for applications in various industries, including pharmaceuticals and cosmetics.

  • Solvent Properties: 2-hydroxypropyl octadecanoate has a limited solubility in water due to its long hydrophobic chain. Its solubility increases significantly in organic solvents such as:
    • Alcohols (e.g., ethanol, isopropanol)
    • Aliphatic hydrocarbons (e.g., hexane, octane)
    • Aromatics (e.g., toluene, benzene)
  • Temperature Influence: The solubility of 2-hydroxypropyl octadecanoate can be affected by temperature, with higher temperatures generally enhancing its solubility in organic solvents.
  • Application Considerations: The ability of 2-hydroxypropyl octadecanoate to dissolve in various solvents makes it a suitable ingredient for:
    • Emollients in skincare formulations
    • Surfactants in detergents
    • Solvents in pharmaceutical applications

In summary, while 2-hydroxypropyl octadecanoate displays low aqueous solubility, its compatibility with organic solvents provides versatility across multiple sectors. As described, its solubility characteristics are essential for effective formulation and usage in various applications.

Interesting facts

Interesting Facts About 2-Hydroxypropyl Octadecanoate

2-Hydroxypropyl octadecanoate, commonly known for its role as a non-ionic surfactant, is a fascinating compound that has garnered attention in both industrial and research settings. Here are some interesting facts about this versatile chemical:

  • Natural Origins: Derived from octadecanoic acid, also known as stearic acid, which can be found in various natural fats and oils, illustrating a strong connection to biological sources.
  • Surfactant Properties: This compound functions as an effective emulsifier, making it essential in the formulation of creams, lotions, and other personal care products. Its ability to stabilize mixtures is key in cosmetic chemistry.
  • Biodegradable Nature: 2-Hydroxypropyl octadecanoate is recognized for its environmental friendliness, as it breaks down easily in nature. This characteristic is increasingly important in an era emphasizing sustainability.
  • Pharmaceutical Applications: It serves as an important ingredient in drug formulation. The compound enhances the solubility of hydrophobic drugs, promoting better absorption in the body, a vital aspect for medicinal chemistry.
  • Safety and Compatibility: Exhibiting low toxicity levels, this compound is often deemed safe for use in various applications, making it suitable for products that come into contact with skin.

In summary, 2-hydroxypropyl octadecanoate stands out not just for its practical uses across industries but also for its sustainable profile and safety features. As science continues to explore its potential, this compound may pave the way for innovations in eco-friendly product formulations.

Synonyms
PROPYLENE GLYCOL MONOSTEARATE
2-Hydroxypropyl stearate
1323-39-3
142-75-6
2-hydroxypropyl octadecanoate
Propylene glycol stearate
Cerasynt PA
Monosteol
Prostearin
Propylene glycol 1-stearate
Octadecanoic acid, 2-hydroxypropyl ester
Pegosperse PS
Monosteol TG
Cerasynt PN
Dragil-P
Tegin P
Propylene glycol 1-monostearate
1,2-Propylene glycol monostearate
NOCA
Crill 26
Nonex 32
Octadecanoic acid, monoester with 1,2-propanediol
Emerest 2381
Noca (VAN)
Propyleneglycol stearate
Emcol PS-50 RHP
Atlas G 924
1,2-Propanediol monostearate
Propylene glycol octadecanoate
Propylene glycol, monostearate
FEMA No. 2942
Propylene glycol monooctadecanoate
1,2-Propanediol monooctadecanoate
Propylene glycol stearic acid ester
Stearic acid, monoester with 1,2-propanediol
Stearic acid, monoester with propane-1,2-diol
32I3MRN561
NCGC00159505-02
Octadecanoic acid,2-hydroxypropyl ester
MFCD00021902
UNII-32I3MRN561
NSC 4841
EINECS 205-557-5
EINECS 215-354-3
AI3-00975
propyleneglycolmonostearate
DSSTox_CID_7381
DSSTox_RID_78430
UNII-MZM1I680W0
DSSTox_GSID_27381
SCHEMBL35521
MZM1I680W0
Propylene glycol palmitostearate
CHEMBL1551666
FEMA NO. 4208
FEMA 2942
DTXSID30872292
CHEBI:177857
FKOKUHFZNIUSLW-UHFFFAOYSA-N
Propylene glycol monostearate [NF]
1, 2-Propylene glycol monostearate
Tox21_111724
83% GC
LMFA07011008
1,2-PROPANEDIOL, 1-STEARATE
AKOS015913883
1-PROPYLENE GLYCOL MONOSTEARATE
HY-W822030
NCGC00159505-03
Propylene glycol monostearate, tech grade
CAS-1323-39-3
STEARIC ACID, 2-HYDROXYPROPYL ESTER
NS00041805
(+/-)-1,2-PROPANEDIOL, 1-STEARATE
E74410
Q27256176
8028-46-4