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Ibuprofen

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Identification
Molecular formula
C13H18O2
CAS number
15687-27-1
IUPAC name
2-(isobutylamino)-1-phenyl-propan-1-ol
State
State

At room temperature, ibuprofen is typically found as a solid in its raw powder form. Its stable, crystalline nature means it remains in this solid state without degradation, although in pharmaceutical applications, it is often dissolved or suspended in solutions for liquid formulations.

Melting point (Celsius)
75.00
Melting point (Kelvin)
348.15
Boiling point (Celsius)
208.00
Boiling point (Kelvin)
481.15
General information
Molecular weight
181.23g/mol
Molar mass
181.2270g/mol
Density
1.0026g/cm3
Appearence

Ibuprofen is a white powder with a crystalline structure. It is almost odorless and still maintains stability in its dry form. Though its crystalline structure is common, it is often manufactured in tablet form for pharmaceutical uses, where it appears as either a white, round, or capsule-shaped tablet.

Comment on solubility

Solubility of 2-(isobutylamino)-1-phenyl-propan-1-ol

The solubility of 2-(isobutylamino)-1-phenyl-propan-1-ol in various solvents is influenced by its unique structure and functional groups. Understanding its solubility is essential for predicting its behavior in different environments. Here are some key points regarding its solubility:

  • Polar solvents: Due to the presence of both an amino group and an alcohol functional group, this compound is likely to be moderately soluble in polar protic solvents like water.
  • Non-polar solvents: Conversely, 2-(isobutylamino)-1-phenyl-propan-1-ol may exhibit reduced solubility in non-polar solvents owing to its polar functional groups that disrupt hydrophobic interactions.
  • Temperature effects: As temperature increases, solubility in both polar and non-polar solvents can vary, typically enhancing the overall solubility due to increased molecular movement.
  • pH influence: The solubility can change with pH, particularly for the amino group which can become protonated at lower pH levels, enhancing aqueous solubility.

In summary, when considering the solubility characteristics of 2-(isobutylamino)-1-phenyl-propan-1-ol, one must take into account its functional groups and environmental conditions. As stated, "The ability of a compound to dissolve is a fascinating interplay of molecular properties and external factors."

Interesting facts

Interesting Facts About 2-(Isobutylamino)-1-phenyl-propan-1-ol

The compound 2-(isobutylamino)-1-phenyl-propan-1-ol, often abbreviated as a sympathomimetic agent, is notable for its role in medicinal chemistry and its implications in pharmacology. Here are some engaging aspects to consider:

  • Pharmacological Action: This compound functions as a selective alpha-adrenergic agonist, which makes it valuable in the study of vasoconstriction and potential therapeutic applications in treating hypotension.
  • Synthetic Routes: It can be synthesized through various organic chemistry techniques, often involving the reaction of isobutylamine with phenylpropanol derivatives.
  • Research Applications: Due to its structural properties, this compound is frequently investigated for its stimulative effects on the central nervous system, particularly in conditions such as attention deficit hyperactivity disorder (ADHD).
  • Regulatory Considerations: Being a compound with dual clinical and recreational interests, it may be subject to regulations that oversee controlled substances in various jurisdictions.
  • Chemical Family: Belonging to the class of beta-phenethylamines, it shares a similar structure and activity with other known sympathomimetics, which can lead to exciting comparative studies with its analogs.

Overall, 2-(isobutylamino)-1-phenyl-propan-1-ol is a fascinating compound that lies at the intersection of drug development and understanding human physiological responses. As research continues to unfold, its potential applications and implications make it an interesting subject for both budding chemists and seasoned scientists alike.