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Aprepitant

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Identification
Molecular formula
C23H21F7N4O
CAS number
170729-80-3
IUPAC name
2-isopropyl-2-(1-naphthyl)-5-(1-piperidyl)pentanenitrile
State
State

At room temperature, Aprepitant is in a solid state.

Melting point (Celsius)
252.00
Melting point (Kelvin)
525.15
Boiling point (Celsius)
541.00
Boiling point (Kelvin)
814.15
General information
Molecular weight
534.43g/mol
Molar mass
534.4340g/mol
Density
1.0480g/cm3
Appearence

Aprepitant is a white to off-white crystalline solid.

Comment on solubility

Solubility of 2-isopropyl-2-(1-naphthyl)-5-(1-piperidyl)pentanenitrile

The solubility characteristics of 2-isopropyl-2-(1-naphthyl)-5-(1-piperidyl)pentanenitrile (C23H21F7N4O) can be quite complex due to its unique molecular structure. Understanding its solubility is essential for various applications, particularly in pharmaceutical settings.

Factors Affecting Solubility

The solubility of this compound can be influenced by several factors:

  • Molecular Polarity: The presence of functional groups can affect the overall polarity of the molecule.
  • Interactions with Solvents: Polar solvents, such as water, may solvate the compound differently compared to nonpolar solvents like hexane.
  • Temperature: Increased temperature generally enhances solubility, but this is not a universal rule.
  • pH Levels: The solubility may vary depending on the pH of the solution, particularly if ionizable groups are present.

General Observations

In general:

  • Organic compounds with significant hydrophobic character often show lower solubility in water.
  • This specific compound, with its aromatic and aliphatic components, may exhibit limited solubility in aqueous solutions but can dissolve more readily in organic solvents.
  • Testing under various conditions is crucial, as empirical data may reveal surprising solubility behavior.

To summarize, the solubility of 2-isopropyl-2-(1-naphthyl)-5-(1-piperidyl)pentanenitrile is shaped by its complex structure and the surrounding environment. As such, one must consider multiple factors to accurately determine its solubility profile.

Interesting facts

Exploring 2-isopropyl-2-(1-naphthyl)-5-(1-piperidyl)pentanenitrile

2-isopropyl-2-(1-naphthyl)-5-(1-piperidyl)pentanenitrile is a compound that has garnered interest in the fields of medicinal chemistry and pharmacology. Here are some fascinating aspects of this intriguing molecule:

Key Characteristics:

  • Structural Diversity: This compound features a complex structure that includes a naphthalene moiety and a piperidine ring, contributing to its unique chemical properties.
  • Biological Relevance: Compounds with similar structural frameworks are often explored for their potential pharmaceutical applications, particularly in the development of novel therapeutics.
  • Interaction Potential: The presence of various functional groups allows for a wide range of interactions with biological targets, making this compound a point of interest for drug design.

Research Implications:

Studies utilizing 2-isopropyl-2-(1-naphthyl)-5-(1-piperidyl)pentanenitrile may provide insights into:

  • Mechanisms of action in biological systems
  • Potential for target specificity in therapeutics
  • Insights into structure-activity relationships (SAR) for similar compounds

Quotes from Scientists:

As researchers delve into the complex realm of medicinal compounds, one might say, "The intricate dance of molecular interactions holds the key to breakthroughs in drug development."

Overall, 2-isopropyl-2-(1-naphthyl)-5-(1-piperidyl)pentanenitrile stands as a testament to the wonders of synthetic chemistry, showcasing how a single compound can open doors to vast possibilities in therapeutic advancements.

Synonyms
13326-36-8
2-naphthalen-1-yl-5-piperidin-1-yl-2-propan-2-ylpentanenitrile
alpha-Isopropyl-alpha-(1-naphtyl)-1-piperidinevaleronitrile
BRN 1594698
1-Piperidinevaleronitrile, alpha-isopropyl-alpha-1-naphthyl-
alpha-Isopropyl-alpha-(3-piperidinopropyl)-1-naphthaleneacetonitrile
1-NAPHTHALENEACETONITRILE, alpha-ISOPROPYL-alpha-(3-PIPERIDINOPROPYL)-
DTXSID10928024
2-(naphthalen-1-yl)-5-(piperidin-1-yl)-2-(propan-2-yl)pentanenitrile