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Amitriptynol

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Identification
Molecular formula
C21H28NO2Cl
CAS number
111-14-8
IUPAC name
2-isopropyl-2-(1-naphthyl)-5-pyrrolidin-1-ium-1-yl-pentanoic acid;chloride
State
State

At room temperature, it exists in a solid state, typically crystalline in structure. It is usually handled as a solid due to its nature and stability in this form.

Melting point (Celsius)
72.00
Melting point (Kelvin)
345.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
370.87g/mol
Molar mass
370.8650g/mol
Density
1.1855g/cm3
Appearence

2-Isopropyl-2-(1-naphthyl)-5-pyrrolidin-1-ium-1-yl-pentanoic acid; chloride appears as a fine, off-white to pale pink powder. It is hygroscopic and may appear clumpy if exposed to moisture.

Comment on solubility

Solubility of 2-isopropyl-2-(1-naphthyl)-5-pyrrolidin-1-ium-1-yl-pentanoic acid; chloride

The solubility of 2-isopropyl-2-(1-naphthyl)-5-pyrrolidin-1-ium-1-yl-pentanoic acid; chloride presents interesting characteristics due to its complex structure. This compound, being a quaternary ammonium salt, typically exhibits the following solubility behaviors:

  • Water Solubility: While many quaternary ammonium compounds are highly soluble in water, the presence of the naphthyl group and the longer alkyl chain may reduce its overall solubility in aqueous solutions.
  • Organic Solvents: It is expected to be more soluble in non-polar organic solvents due to the hydrophobic nature of the naphthalene moiety.
  • Dissociation: Upon solvation, this compound would dissociate into cations and anions, which can further influence its interactions with solvents.

In practice, factors like temperature, pH, and the presence of other ions in solution can greatly influence the solubility of this compound. It is essential to note that experimental data will provide the most accurate insight into its solubility profile. As quoted by many chemists, "solubility is not just about the compound itself, but also about its environment." Understanding these interactions is crucial in predicting behavior in biological systems or chemical formulations.

Interesting facts

Interesting Facts About 2-isopropyl-2-(1-naphthyl)-5-pyrrolidin-1-ium-1-yl-pentanoic acid;chloride

This compound, known for its complex structure, belongs to a class of molecules that exemplify intriguing pharmaceutical potential. Here are some fascinating insights about this compound:

  • Pharmacological Significance: This compound has been studied for its potential use as a therapeutic agent, particularly in the treatment of neurological disorders. Its structural features suggest that it may interact effectively with various neurotransmitter systems.
  • Structural Complexity: The presence of both isopropyl and naphthyl groups contributes to its unique chemical properties. The naphthyl moiety can enhance lipophilicity, which may influence how the compound interacts with biological membranes.
  • Chloride Salt Form: As a chloride salt, this compound may exhibit improved stability and solubility characteristics compared to its base form, making it a favorable candidate for formulation in pharmaceutical applications.
  • Pyrrolidine Ring: The pyrrolidine ring in its structure is notable for its function in drug design, often associated with increased biological activity due to its ability to mimic natural neurotransmitter structures.
  • Research Endeavors: Ongoing studies into such compounds are critical for advancing our understanding of their mechanisms of action and for discovering new therapeutic uses.

The exploration of 2-isopropyl-2-(1-naphthyl)-5-pyrrolidin-1-ium-1-yl-pentanoic acid;chloride represents the dynamic intersection of synthetic chemistry and pharmacology. With its multifaceted structure and potential for significant biological activity, it continues to intrigue scientists and pave the way for innovative drug development.

Synonyms
1-Naphthaleneacetic acid, alpha-isopropyl-alpha-(3-pyrrolidinopropyl)-, hydrochloride
6733-68-2
alpha-Isopropyl-alpha-(3-pyrrolidinopropyl)-1-naphthaleneacetic acid hydrochloride