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Buspirone hydrochloride

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Identification
Molecular formula
C21H31Cl2N5O2
CAS number
33386-08-2
IUPAC name
2-methoxy-4-[(4-pyrimidin-2-ylpiperazin-1-yl)methyl]phenol;dihydrochloride
State
State

At room temperature, buspirone hydrochloride is also in a solid state and often used in pill or tablet formulations in the pharmaceutical industry.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
461.44g/mol
Molar mass
461.4350g/mol
Density
1.2301g/cm3
Appearence

Buspirone hydrochloride typically appears as a white or off-white crystalline powder. It is generally odorless and can be dissolved in water, a feature characteristic of its hydrochloride salt form.

Comment on solubility

Solubility of 2-methoxy-4-[(4-pyrimidin-2-ylpiperazin-1-yl)methyl]phenol; dihydrochloride

The solubility of 2-methoxy-4-[(4-pyrimidin-2-ylpiperazin-1-yl)methyl]phenol; dihydrochloride is an important characteristic that influences its application in various fields. Here’s an overview of its solubility behavior:

  • Solvent Dependency: This compound is known to exhibit varying solubility in aqua (water) and organic solvents. Its solubility can be significantly influenced by the pH and temperature of the solvent.
  • Water Solubility: Being a dihydrochloride salt, it is expected to have a higher solubility in water compared to its free base form. It is particularly soluble due to the presence of charged groups that interact favorably with water molecules.
  • Organic Solvents: Solubility in organic solvents may differ widely. Compounds with similar structures often exhibit better solubility in polar organic solvents such as methanol or ethanol, though less in non-polar solvents.

To summarize, the solubility of this compound is largely influenced by environmental conditions and solvent type. Understanding the solubility properties is crucial for formulation and delivery in medicinal chemistry, where high solubility is often a desired trait for effective drug action.

Interesting facts

Interesting Facts about 2-Methoxy-4-[(4-pyrimidin-2-ylpiperazin-1-yl)methyl]phenol Dihydrochloride

This intriguing compound belongs to a class of chemicals known for their potential pharmacological properties. It primarily acts as a ligand in medicinal chemistry, which makes it a subject of interest in drug discovery efforts. Here are some fascinating aspects of 2-methoxy-4-[(4-pyrimidin-2-ylpiperazin-1-yl)methyl]phenol dihydrochloride:

  • Pharmacological Potential: This compound has been investigated for its role in targeting various biological pathways, making it a candidate for developing medicines that address neurological disorders.
  • Structural Significance: The presence of both a pyrimidine and a piperazine moiety in its structure is noteworthy, as these groups are often involved in interactions with biological receptors.
  • Mechanism of Action: Research suggests that the compound may influence neurotransmitter systems, potentially offering avenues for treatment options in psychiatric and cognitive disorders.
  • Synthesis Pathways: The synthesis of this compound involves multiple steps, emphasizing the importance of precision and control in synthetic organic chemistry.
  • Research Applications: This chemical has served as a lead compound for further modifications, enabling scientists to explore its derivatives and their enhanced activity.
  • Interdisciplinary Appeal: The study of this compound bridges various fields, including medicinal chemistry, pharmacology, and organic synthesis, showcasing the interdisciplinary nature of modern scientific research.

In conclusion, 2-methoxy-4-[(4-pyrimidin-2-ylpiperazin-1-yl)methyl]phenol dihydrochloride is a compound that presents exciting opportunities for researchers interested in the development of new therapeutic agents. As scientists unpack the intricacies of its behavior, this compound could play a significant role in unraveling complex biological systems and improving human health.

Synonyms
p-Cresol, 2-methoxy-alpha-(4-(2-pyrimidinyl)-1-piperazinyl)-, hydrochloride, hydrate (2:4:1)
3601-83-0
DTXSID90189575
1-(3-Methoxy-4-hydroxybenzyl)-4-(2-pyrimidyl)-piperazine hydrochloride hydrate
2-Methoxy-alpha-(4-(2-pyrimidinyl)-1-piperazinyl)-p-cresol hydrochloride hydrate (2:4:1)
DTXCID50112066