Skip to main content

Methiothepin

ADVERTISEMENT
Identification
Molecular formula
C20H25N2OS
CAS number
1100-75-6
IUPAC name
2-methoxy-8-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine
State
State

Methiothepin is typically a solid at room temperature.

Melting point (Celsius)
70.00
Melting point (Kelvin)
343.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
379.56g/mol
Molar mass
379.5600g/mol
Density
1.3600g/cm3
Appearence

Methiothepin typically appears as a crystalline powder. Its color can range from white to off-white.

Comment on solubility

Solubility of 2-methoxy-8-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine

The solubility of 2-methoxy-8-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine can be influenced by several factors, primarily its molecular structure and polarity. Understanding its solubility is crucial for applications in pharmaceuticals, as it pertains to drug formulation and bioavailability. Here are some key points regarding its solubility:

  • Polar vs. Non-polar: The presence of functional groups such as the methoxy and piperidyl moieties contributes to a more polar character, which typically enhances solubility in polar solvents.
  • Drug Solubility: Generally, compounds with similar polarities to the solvent will exhibit higher solubility. As such, 2-methoxy-8-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine may have increased solubility in solvents like ethanol or methanol.
  • Solvent Selection: For maximum solubility, it is advisable to consider solvents like:
    • Water (to a limited extent)
    • Ethanol
    • DMSO (Dimethyl sulfoxide)
  • Temperature Effects: Increasing the temperature often enhances solubility for many compounds, making it a useful consideration during practical applications.

In conclusion, while this compound exhibits some degree of solubility due to its functional groups, the exact solubility profile may require empirical testing to ensure optimal conditions for its use in various chemical and pharmaceutical contexts.

Interesting facts

Interesting Facts about 2-methoxy-8-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine

2-methoxy-8-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine, commonly known for its therapeutic applications, is part of a larger family of compounds known as phenothiazines. These compounds have demonstrated significant relevance in various fields of science, particularly in medicinal chemistry.

Therapeutic Applications

  • Antipsychotic Properties: Phenothiazines, including this compound, are well-known for their role as antipsychotic agents used in the treatment of schizophrenia and other mental disorders.
  • Anti-emetic Effects: Some derivatives have shown efficacy in preventing nausea and vomiting, making them valuable in chemotherapy protocols.
  • Potential Uses: Research is ongoing into their anti-inflammatory and analgesic properties, indicating a broad spectrum of potential applications.

Chemical Structure Insights

The innovative structure of this compound plays a pivotal role in its biological activity:

  • Phenothiazine ring system: This core structure is crucial for the interaction with neurotransmitter receptors.
  • Piperidine side chain: The presence of a piperidine moiety enhances its receptor affinity, impacting its pharmacological profile.

As a chemical scientist, I find the interactions between the molecular structure and biological activity particularly fascinating. According to a recent study, researchers noted that "the modifications in the side chains and functional groups of phenothiazine derivatives can drastically alter their efficacy and selectivity." This statement emphasizes the importance of structure-activity relationships in the development of new therapeutics.

Future Directions

The exploration of this compound and its derivatives continues to captivate researchers. There is an ongoing effort to:

  • Enhance selectivity for specific receptor subtypes to minimize side effects.
  • Investigate potential new therapeutic uses beyond psychiatry.
  • Develop novel formulations that improve bioavailability.

In summary, 2-methoxy-8-[2-(1-methyl-2-piperidyl)ethyl]-10H-phenothiazine represents a fascinating intersection of chemistry and medicine, epitomizing the potential of phenothiazines in addressing complex health challenges.