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2-Methoxybenzohydrazide

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Identification
Molecular formula
C8H10N2O2
CAS number
4665-81-2
IUPAC name
2-methoxybenzohydrazide
State
State

At room temperature, 2-Methoxybenzohydrazide is in a solid state.

Melting point (Celsius)
127.00
Melting point (Kelvin)
400.15
Boiling point (Celsius)
327.00
Boiling point (Kelvin)
600.15
General information
Molecular weight
166.18g/mol
Molar mass
166.1800g/mol
Density
1.1920g/cm3
Appearence

2-Methoxybenzohydrazide is typically found as a crystalline solid. It is often off-white to pale yellow in color.

Comment on solubility

Solubility of 2-Methoxybenzohydrazide

2-Methoxybenzohydrazide, also known as (2-methoxyphenyl)hydrazinecarboxamide, exhibits interesting solubility characteristics that can be crucial for its application in various chemical processes. The solubility of this compound is influenced by several factors, including:

  • Polarity: The presence of the methoxy group (-OCH3) increases the polarity of the molecule, which can enhance its solubility in polar solvents.
  • Hydrogen Bonding: 2-Methoxybenzohydrazide has functional groups capable of forming hydrogen bonds, making it more soluble in solvents that can engage in similar interactions.
  • Solvent Choice: It is generally more soluble in organic solvents such as methanol and ethanol compared to water, due to its aromatic structure.

In summary, while 2-methoxybenzohydrazide demonstrates moderate solubility, its behavior highlights the interplay between chemical structure and solvent interactions. As a rule of thumb, if you're looking to dissolve this compound, opt for polar organic solvents to achieve the best results.

Interesting facts

Facts about 2-Methoxybenzohydrazide

2-Methoxybenzohydrazide, often referred to as a hydrazine derivative, is a compound that has garnered attention in the fields of organic chemistry and medicinal research due to its intriguing properties and potential applications. Here are some interesting aspects of this compound:

  • Synthetic Versatility: This compound can be synthesized through a straightforward reaction involving methoxybenzoic acid and hydrazine, demonstrating the ease with which hydrazones and hydrazides can be constructed in laboratory settings.
  • Biological Activity: Research indicates that compounds like 2-methoxybenzohydrazide may exhibit significant biological activities, particularly in the realms of antitumor and antimicrobial properties. Such findings emphasize the importance of further exploration in drug development.
  • Structure-Activity Relationship: The presence of the methoxy group is noteworthy. It plays a crucial role in modulating the compound's reactivity, stability, and biological efficacy. Chemists often study this relationship to understand how structural modifications can enhance performance.
  • Research Applications: 2-Methoxybenzohydrazide has been utilized as a key intermediate in the synthesis of various pharmaceuticals, serving as a building block for more complex molecules.
  • Analytical Techniques: Analytical scientists often employ techniques like NMR and mass spectrometry to characterize this compound thoroughly, showcasing its significance in both pure and applied research settings.

Overall, 2-methoxybenzohydrazide is a fascinating compound that exemplifies the interconnectedness of synthetic chemistry and biological research. Its diverse applications make it a valuable asset for scientists and researchers alike, enhancing our understanding of chemical reactivity and potential therapeutic uses.

Synonyms
2-Methoxybenzohydrazide
o-Anisohydrazide
2-Methoxybenzhydrazide
7466-54-8
2-Methoxybenzoyl hydrazide
2-Methoxybenzoic acid hydrazide
o-Methoxybenzohydrazide
o-Methoxybenzoylhydrazine
2-Methoxybenzoylhydrazide
2-Methoxybenzoylhydrazine
O-ANISIC HYDRAZIDE
Hydrazine, 2-methoxybenzoyl-
o-Methoxybenzoylhydrazide
o-Methoxybenzoic acid hydrazide
o-ANISIC ACID, HYDRAZIDE
Benzoic acid, o-methoxy-, hydrazide
Benzoic acid, 2-methoxy-, hydrazide
MFCD00014755
NSC 402658
o-Methoxybenzhydrazide
19I9PY8G1D
CHEMBL3237776
NSC-402658
EINECS 231-260-5
BRN 2208367
UNII-19I9PY8G1D
O-Anisic acid,hydrazide
O-Anisic acid-,hydrazide
2-Methoxybenzohydrazide #
WLN: ZMVR BO1
Oprea1_317212
4-10-00-00199 (Beilstein Handbook Reference)
SCHEMBL295407
DTXSID70225642
AC8262
BDBM50001676
NSC402658
STK121706
AKOS000141259
CS-W003975
FA54996
AS-11269
SY061614
DB-021289
NS00037645
EN300-49192
2-Methoxybenzoic acid hydrazide;2-Methoxybenzhydrazide
Q27252107
Z57318022
F1724-0145