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2-Methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one

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Identification
Molecular formula
C11H14N2O
CAS number
144531-72-0
IUPAC name
2-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one
State
State

At room temperature, 2-Methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one is typically a solid.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
305.00
Boiling point (Kelvin)
578.15
General information
Molecular weight
190.24g/mol
Molar mass
190.2430g/mol
Density
1.2000g/cm3
Appearence

2-Methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one typically appears as a crystalline solid. The color varies depending on the specific conditions and purity of the sample but can range from white to off-white or even pale yellow.

Comment on solubility

Solubility of 2-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one

The solubility of 2-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one is an intriguing aspect that can influence its applications in various fields, particularly in pharmaceuticals. Understanding its solubility properties is essential for effective formulation and utilization. Here are some key points to consider:

  • Solvent Interactions: The compound's solubility is affected by its interactions with solvents. This compound is generally more soluble in polar solvents, such as water and ethanol, than in non-polar solvents.
  • Temperature Effect: As with many organic compounds, increasing temperature can enhance solubility. Thus, solubility may increase when the temperature rises.
  • pH Dependence: The solubility of the compound may vary depending on the pH of the solution, reflecting its potential ionization in varying pH conditions.
  • Concentration Threshold: There exists a concentration threshold beyond which the solubility may decrease, leading to precipitation if the solution becomes supersaturated.
  • Formulation Considerations: For pharmaceutical applications, the bioavailability of 2-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one may be significantly influenced by its solubility, necessitating careful formulation strategies.

In summary, while there is a foundational understanding of the solubility characteristics of 2-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one, specific data on its solubility parameters may require further investigation. Optimal solubility conditions can play a crucial role in maximizing its effectiveness and application in various sectors.

Interesting facts

Interesting Facts about 2-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one

The compound 2-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one, a derivative of the benzodiazepine family, serves as a fascinating subject in the realms of medicinal chemistry and pharmacology. Here are some noteworthy insights about this intriguing compound:

  • Pharmacological Relevance: This compound is explored for its potential therapeutic applications, particularly in the fields of anxiety and sedation. Benzodiazepines are widely known for enhancing the effects of the neurotransmitter GABA, leading to a calming effect on the central nervous system.
  • Chemical Structure: The unique structure of benzodiazepines allows for a diverse range of chemical modifications. The introduction of the methyl group in 2-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one has implications for its biological activity and potency.
  • Research Potential: Ongoing studies are investigating the pharmacokinetics and pharmacodynamics of this compound. The understanding of its interaction with various receptors could pave the way for the development of new anxiolytic medications with improved safety profiles.
  • Safety Considerations: While benzodiazepines are effective, they also carry risks of dependence and withdrawal symptoms. This compound, like others in its class, necessitates careful consideration during its evaluation for clinical use.
  • Analytical Techniques: The study of this chemical often involves advanced analytical techniques including NMR (nuclear magnetic resonance) and mass spectrometry to elucidate its structural features and stability under various conditions.

As with many synthetic compounds, the path from conceptualization to application is complex. Chemists and pharmacologists are continually expanding their understanding of compounds like 2-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one, highlighting the interplay between structure and function in the development of therapeutic agents.

Synonyms
4-Methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one
NSC 36330
BRN 0166063
1H-1,5-BENZODIAZEPIN-2-ONE, 2,3,4,5-TETRAHYDRO-4-METHYL-
5-24-02-00516 (Beilstein Handbook Reference)
621-866-1
3967-01-9
4-Methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one
4-methyl-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one
2-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one
MFCD00024148
(Rac)-CPI-098
MLS002607962
CPI098
CHEMBL2142704
4-Methyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
NSC36330
4-Methyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one
BBPWQLMHOSRDMA-UHFFFAOYSA-N
Maybridge1_000473
Oprea1_799819
F0266-2229
SCHEMBL4902318
4-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one
HMS542N11
CHEBI:194928
HMS3080B19
ALBB-017639
BDBM50178217
NSC-36330
STK866163
AKOS000272070
AKOS016039074
MS-2384
SMR001335214
DB-049463
DB-263177
HY-109706
CS-0033862
EN300-09458
G92423
AE-473/30685015
SR-01000394501
SR-01000394501-1
Z56979282
4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2one
2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-