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2-Methylindole

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Identification
Molecular formula
C9H9N
CAS number
95-20-5
IUPAC name
2-methyl-1H-indole
State
State

At room temperature, 2-Methylindole is typically a solid. It appears as solid crystals or powder.

Melting point (Celsius)
58.00
Melting point (Kelvin)
331.15
Boiling point (Celsius)
245.00
Boiling point (Kelvin)
518.15
General information
Molecular weight
131.17g/mol
Molar mass
131.1740g/mol
Density
1.0650g/cm3
Appearence

2-Methylindole is usually found as a pale yellow to brown solid. It occasionally appears as a crystalline powder and is known for having a strong odor.

Comment on solubility

Solubility of 2-methyl-1H-indole

The solubility of 2-methyl-1H-indole, a compound with the molecular formula C10H9N, can be quite intriguing. It is primarily characterized as being **slightly soluble** in water, reflecting its aromatic structure and a significant hydrophobic character. Here are some important points to consider regarding its solubility:

  • Solvent Polarity: The hydrophobic nature of the indole ring diminishes the compound's affinity for polar solvents like water.
  • Organic Solvents: 2-methyl-1H-indole is significantly more soluble in non-polar or less polar organic solvents such as ethanol, acetone, and chloroform.
  • Temperature Effect: Increasing temperature often enhances the solubility of organic compounds, including 2-methyl-1H-indole, in organic solvents.

As a rule of thumb, when dealing with organic compounds such as 2-methyl-1H-indole, it is essential to consider the solvent's characteristics and the molecular structure of the compound. In summary, while water's solubility is limited, the compound thrives in less polar environments.

Interesting facts

Exploring 2-methyl-1H-indole

2-methyl-1H-indole is an intriguing compound belonging to the indole family, a class of heterocyclic compounds notable for their unique ring structure and aromatic properties. Here are some fascinating facts about this compound:

  • Natural Occurrence: Indole derivatives are widely found in nature. 2-methyl-1H-indole, in particular, can be derived from the metabolism of tryptophan, an essential amino acid, indicating its significance in biological systems.
  • Biological Activities: This compound exhibits various biological activities. Research indicates that 2-methyl-1H-indole may have roles in anti-inflammatory and anti-cancer properties, making it a candidate for further pharmacological studies.
  • Odor Characteristics: Many indole derivatives possess a distinctive smell, often described as floral or fecal. The presence of 2-methyl-1H-indole can contribute to complex scents in flowers and certain foods, showcasing the compound's influence on sensory perceptions.
  • Research Potential: The unique structure of 2-methyl-1H-indole opens avenues for synthetic chemists to explore its applications in creating novel pharmaceuticals, agrochemicals, and materials.
  • Structure-Activity Relationship (SAR): Scientists study various indole derivatives to understand how structural modifications affect their biological activity, thus enhancing the discovery of therapeutic agents. 2-methyl-1H-indole serves as an excellent prototype for investigating these relationships.

In the words of the famous chemist Linus Pauling, "Science is not only compatible with spirituality; it is a profound source of spirituality." This sentiment resonates with the study of compounds like 2-methyl-1H-indole, as researchers delve into the intricate connections between chemical structure and biological function.

Overall, 2-methyl-1H-indole embodies the beauty and complexity of organic chemistry, further igniting the passion for discovery among scientists and students alike.

Synonyms
2-METHYLINDOLE
2-Methyl-1H-indole
95-20-5
1H-Indole, 2-methyl-
Indole, 2-methyl-
NSC 7514
EINECS 202-398-3
MFCD00005616
UNII-I7CN58827I
CHEBI:49402
AI3-03945
I7CN58827I
NSC-7514
DTXSID5059117
2-METHYL INDOLE
2-methylindol
Methylketole
methyl indole
2Methyl1Hindole
2-methyl-indole
Indole, 2methyl
1H-Indole, 2-methyl-; Indole, 2-methyl- (8CI); 2-Methyl-1H-indole; 2-Methylindole; NSC 7514
1HIndole, 2methyl
2-methyl-1h-indol
2-methyl-1-H-indole
2-Methylindole, 98%
Indole, 2methyl (8CI)
Indole, 2-methyl-(8CI)
SCHEMBL12420
a-Methylindole; NSC 7514
SCHEMBL377807
CHEMBL259419
F0290-0682
DTXCID8048947
NSC7514
KUC106612N
2-Methylindole, analytical standard
KSC-09-215A
STR01200
AC-611
STK044221
AKOS000119568
CG-0500
CS-W007556
FM02013
HY-W007556
SB14955
NCGC00342152-01
DB-031753
2-Methylindole, purum, >=97.5% (HPLC)
M0346
NS00010851
EN300-18136
AB00375786-04
Q4596907
202-398-3
2MI