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2-methylquinazolin-4-one

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Identification
Molecular formula
C9H8N2O
CAS number
6312-24-9
IUPAC name
2-methyl-1H-quinazolin-4-one
State
State

At room temperature, 2-methylquinazolin-4-one is in a solid state.

Melting point (Celsius)
162.00
Melting point (Kelvin)
435.00
Boiling point (Celsius)
279.00
Boiling point (Kelvin)
552.00
General information
Molecular weight
160.17g/mol
Molar mass
160.1740g/mol
Density
1.2500g/cm3
Appearence

2-Methylquinazolin-4-one typically appears as a crystalline solid. It may present in a white to off-white color, depending on its purity and specific sample form.

Comment on solubility

Solubility of 2-methyl-1H-quinazolin-4-one

2-methyl-1H-quinazolin-4-one, with its complex structure, exhibits interesting solubility characteristics that are worth exploring. When considering its solubility in various solvents, several factors come into play:

  • Polar vs. Nonpolar Solvents: This compound tends to be more soluble in polar solvents such as water and ethanol due to the presence of functional groups that can form hydrogen bonds.
  • Temperature Influence: Like many organic compounds, the solubility of 2-methyl-1H-quinazolin-4-one typically increases with temperature, a behavior that is essential for practical applications.
  • pH Effects: The solubility may also vary with pH, especially if ionizable groups are present in the structure, affecting its interaction with the solvent.

In general, it has been noted that "the solubility of 2-methyl-1H-quinazolin-4-one in organic solvents is typically moderate," making it suitable for various chemical synthesis processes.

Overall, understanding the solubility of this compound is crucial for its applications in research and industry, particularly in the fields of pharmaceuticals and agrochemicals.

Interesting facts

2-Methyl-1H-quinazolin-4-one

2-Methyl-1H-quinazolin-4-one is an intriguing organic compound known for its versatile applications in various fields of science, particularly in pharmaceuticals and agrochemicals. Here are some fascinating aspects about this compound:

  • Pharmaceutical Applications: This compound has been investigated for its potential as a therapeutic agent. It has shown promise in the development of anti-cancer drugs due to its ability to interfere with crucial biological pathways involved in tumor growth.
  • Agrochemical Significance: Beyond its medical implications, 2-methyl-1H-quinazolin-4-one is also utilized in the agrochemical industry. It can serve as a precursor for molecules that exhibit herbicidal properties, significantly aiding in crop protection.
  • Structure-Activity Relationship: The quinazolinone structure is pivotal in medicinal chemistry. Research often explores how variations in small functional groups, such as the methyl group in 2-methyl-1H-quinazolin-4-one, can dramatically impact biological activity, making it a subject of interest in drug design.
  • Synthesis Strategies: The synthesis of 2-methyl-1H-quinazolin-4-one involves several chemical pathways, including cyclization reactions and selective methylation. Understanding these synthesis techniques is crucial for researchers aiming to optimize yield and purity.
  • Research Potential: Ongoing studies continue to uncover novel derivatives of this compound, which may lead to the discovery of new compounds with enhanced pharmacological properties. Scientists are excited about the potential for new discoveries within the quinazolinone framework.

In summary, 2-methyl-1H-quinazolin-4-one stands as a promising candidate in the realm of medicinal and agricultural chemistry. Its unique properties and versatile applications make it a subject of significant scientific interest. As the exploration of its capabilities progresses, we can anticipate new findings that might contribute to advances in health and sustainability.