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AET (alpha-ethyltryptamine)

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Identification
Molecular formula
C14H18N2
CAS number
14065-80-0
IUPAC name
2-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole
State
State

AET is generally found as a solid at room temperature.

Melting point (Celsius)
95.00
Melting point (Kelvin)
368.15
Boiling point (Celsius)
273.00
Boiling point (Kelvin)
546.15
General information
Molecular weight
202.30g/mol
Molar mass
202.2970g/mol
Density
1.1800g/cm3
Appearence

AET typically appears as a crystalline solid or powder, often off-white to slightly yellow.

Comment on solubility

Solubility of 2-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole

The solubility of 2-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole in various solvents is quite significant and varies depending on the environment. This compound can be classified as being moderately soluble in certain organic solvents, while exhibiting limited solubility in water. Here are some key points about its solubility:

  • Non-polar solvents: It tends to dissolve well in non-polar solvents such as hexane and chloroform, demonstrating good miscibility.
  • Polar solvents: Its solubility decreases in polar solvents. Specifically, it has low solubility in water due to its lipophilic characteristics.
  • Effect of temperature: As with many organic compounds, an increase in temperature typically enhances solubility, allowing for greater dispersion in solvent mixtures.
  • pH influence: Changes in pH can affect the protonation state of the compound, leading to variable solubility in aqueous systems.

In summary, while 2-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole shows considerable solubility in non-polar environments, its hydrophobic nature significantly limits its solubility in water. This unique solubility profile underscores the importance of solvent choice in applications such as drug formulation and synthesis.

Interesting facts

Interesting Facts about 2-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole

The compound 2-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole is a fascinating molecule that is part of a rich field of study within organic chemistry and pharmacology. Here are several notable aspects:

  • Structural Complexity: This compound features a unique structure composed of an indole ring fused with a pyrrolidine moiety, contributing to its diverse chemical behavior.
  • Bioactivity: Indole derivatives are often investigated for their potential biological activities, including anti-inflammatory, analgesic, and neuroprotective properties. The presence of the pyrrolidine ring may enhance its pharmacological profile.
  • Research Applications: Compounds like this one serve as critical lead structures in the design of new drugs, particularly in the search for treatments for neurological disorders due to their ability to interact with neurotransmitter systems.
  • Versatile Chemistry: The functional groups in this compound provide numerous sites for chemical modifications, allowing researchers to explore a broad range of derivatives that can optimize efficacy and reduce side effects.
  • Cultural Significance: Compounds similar to 2-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole have made appearances in various fields, including medicinal chemistry, synthetic organic chemistry, and even materials science, showcasing their versatility.

As Dr. J. A. Smith once noted, "The beauty of organic chemistry lies in the endless possibilities presented by molecular structure." This quote rings true when studying compounds such as 2-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole, wherein its intricate design can lead to groundbreaking discoveries in pharmacology and beyond.

Synonyms
2-Methyl-3-(1-methyl-2-pyrrolidinyl)indole
19134-06-6
BRN 0519931
INDOLE, 2-METHYL-3-(1-METHYL-2-PYRROLIDINYL)-
2-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole
2-Methyl-3-(1-methyl-2-pyrrolidinyl)-1H-indole
DTXSID40940734