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2-Methyl-3-(1-piperidyl)pyrazine

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Identification
Molecular formula
C10H15N3
CAS number
71788-79-3
IUPAC name
2-methyl-3-(1-piperidyl)pyrazine
State
State

At room temperature, 2-Methyl-3-(1-piperidyl)pyrazine is in a liquid state. It’s part of a class of compounds that typically have moderate volatility due to the presence of nitrogen atoms within their molecular structure.

Melting point (Celsius)
-42.90
Melting point (Kelvin)
230.25
Boiling point (Celsius)
267.70
Boiling point (Kelvin)
540.85
General information
Molecular weight
177.25g/mol
Molar mass
177.2580g/mol
Density
1.0557g/cm3
Appearence
2-Methyl-3-(1-piperidyl)pyrazine typically appears as a liquid at room temperature. Its physical properties such as color and viscosity may vary, but it is generally clear and may possess a specific chemical odor characteristic to organic compounds containing nitrogen.
Comment on solubility

Solubility of 2-methyl-3-(1-piperidyl)pyrazine

The solubility of 2-methyl-3-(1-piperidyl)pyrazine is a key characteristic that influences its behavior in various chemical processes. This compound, which features both a pyrazine ring and a piperidine moiety, exhibits unique solubility properties due to the following factors:

  • Polarity: The presence of the piperidine group enhances polarity, which can increase solubility in polar solvents such as water and alcohols.
  • Hydrogen bonding: Functional groups in 2-methyl-3-(1-piperidyl)pyrazine are capable of forming hydrogen bonds, further facilitating solubility in polar environments.
  • Solvent interactions: The solubility is significantly affected by the choice of solvent. For example, it may dissolve well in dimethyl sulfoxide (DMSO) or ethanol while exhibiting lower solubility in non-polar solvents.

In practice, the compound's solubility can be summarized as follows:

  • Highly soluble in polar solvents
  • Moderately soluble in some organic solvents
  • Low solubility in non-polar solvents

It's essential to consider these characteristics when preparing solutions for synthesis or biological assays, as they play a critical role in determining the compound's reactivity and bioavailability.

Interesting facts

Interesting Facts About 2-Methyl-3-(1-piperidyl)pyrazine

2-Methyl-3-(1-piperidyl)pyrazine is an intriguing compound with a range of applications and one that offers fascinating insights into its chemistry and potential uses.

Chemical Structure and Properties

  • Pyrazine Ring: The compound features a six-membered aromatic ring known as a pyrazine. This heterocyclic structure is known for its diverse reactivity and ability to participate in numerous chemical interactions.
  • Piperidine Linkage: The presence of a 1-piperidyl group contributes to the compound’s ability to form hydrogen bonds, enhancing its solubility characteristics and interactions with biological systems.
  • Methyl Substituent: The 2-methyl group on the pyrazine ring can influence electronic distribution and steric effects, modifying the reactivity of the compound dramatically.

Biological Significance

This compound has attracted attention in the field of medicinal chemistry due to its potential pharmacological properties. Here are a few notable points:

  • It is often studied in the context of developing new antidepressants and anti-anxiety medications, owing to its piperidine moiety.
  • Research has indicated that derivatives of pyrazine compounds exhibit various levels of antimicrobial and antitumor activities, making them candidate compounds for drug development.

Practical Applications

In addition to its biological significance, 2-methyl-3-(1-piperidyl)pyrazine may find uses in:

  • Flavoring Agents: Pyrazine compounds are often employed in the food industry to enhance flavor profiles.
  • Fragrance Industry: The unique aroma of pyrazines can also be utilized in perfumes and scented products.

Conclusion

In conclusion, 2-methyl-3-(1-piperidyl)pyrazine is not only a compound of academic interest but also a potentially valuable substance in various industries. Its multifaceted chemical properties and biological activities make it a prime candidate for further research. As expressed by renowned chemists, "The chemistry of small molecules can lead to big breakthroughs." This compound exemplifies that sentiment and opens doors for innovative applications in medicine and beyond.

Synonyms
MODALINE
Modaline [INN]
Modalina
Modalin
2-Methyl-3-piperidinopyrazine
2856-74-8
Pyrazine, 2-methyl-3-(1-piperidinyl)-
Modalinum
Modalinum [INN-Latin]
Modalina [INN-Spanish]
Pyrazine, 2-methyl-3-piperidino-
2-Methyl-3-(1-piperidinyl)pyrazine
BRN 0611786
UNII-0M6T2W2993
0M6T2W2993
DTXSID00182774
5-25-10-00199 (Beilstein Handbook Reference)
Modalinum (INN-Latin)
Modalina (INN-Spanish)
DTXCID40105265
Pyrazine, 2-methyl-3-piperidino-(8CI)
bjhcgmhpeklrom-uhfffaoysa-n
2-methyl-3-piperidin-1-ylpyrazine
Modaline sulfate(USAN)
SCHEMBL2107814
CHEMBL2111121
2-methyl-3-(1-piperidyl)pyrazine
AKOS006272561
2-Methyl-3-(1-piperidinyl)pyrazine #
NS00114057
AB01563343_01
BRD-K25317177-065-01-4
Q27236960
Sulfuric acid compound with 2-methyl-3-(1-piperidinyl)pyrazine (1:1)