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2-Methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole

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Identification
Molecular formula
C21H25N3
CAS number
137000-78-3
IUPAC name
2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole
State
State

At room temperature, this compound is typically found as a solid due to its high molecular weight and strong intermolecular forces.

Melting point (Celsius)
138.00
Melting point (Kelvin)
411.15
Boiling point (Celsius)
508.50
Boiling point (Kelvin)
781.70
General information
Molecular weight
333.45g/mol
Molar mass
333.4470g/mol
Density
1.2300g/cm3
Appearence

This complex organic compound typically appears as a white or off-white crystalline powder. Its texture and color can vary slightly depending on the degree of purity and form in which it is prepared.

Comment on solubility

Solubility of 2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole

The solubility of 2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole in various solvents is a critical factor for its application in pharmaceuticals and research. Analyzing its solubility provides insights into its potential uses and formulations. Here are some considerations regarding its solubility:

  • Polarity: The structure indicates the presence of both hydrophobic (non-polar) and hydrophilic (polar) regions, suggesting that the compound may exhibit varying solubility in different solvents.
  • Solvent Type: It is likely to be more soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), while showing lower solubility in water due to its hydrophobic character.
  • Temperature Effects: As with many organic compounds, solubility may increase with temperature, highlighting the importance of solvent conditions during experimentation.
  • pH Dependence: The solubility can also be influenced by the pH of the solution, especially if functional groups in the structure can accept or donate protons.

In conclusion, understanding the solubility of 2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole is paramount for its optimal use in various chemical applications. It is essential to explore different solvents and conditions to fully characterize its behavior in solution.

Interesting facts

Interesting Facts about 2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole

The compound 2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole is a fascinating member of the indole family, which is renowned for its applications in various fields of medicinal chemistry. Here are some enticing insights:

  • Pharmacological Potential: This compound is considered a promising lead molecule in the development of new therapeutic agents. Its structure provides a basis for exploring treatments for mental health disorders and neurological conditions.
  • Structure Activity Relationship (SAR): The presence of both the indole and piperazine moieties might allow researchers to modify and improve the compound's efficacy and selectivity for specific biological targets. This is critical in optimizing drug design.
  • Diverse Biological Activities: Compounds related to 1H-indole are known for a variety of biological effects, including:
    • Antidepressant
    • Antipsychotic
    • Anti-inflammatory
  • Research Interest: 2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole has garnered attention in academic research due to its potential to act on neurotransmitter systems, particularly involving serotonin and dopamine.
  • Future Prospects: As scientists continue to investigate the pharmacological profiles of indole derivatives, compounds like this one serve as valuable scaffolds for creating innovative and effective drugs. The ongoing research could lead to breakthroughs in treating conditions such as anxiety, depression, and schizophrenia.

In conclusion, this compound is not just a structural curiosity; it embodies a blend of chemistry and biopharmaceutical potential that makes it a significant subject for ongoing research. The synergy between its chemical structure and biological activity makes 2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole a compelling compound for both current studies and future therapeutic applications.

Synonyms
WIN 18437
4121-77-1
BRN 0553036
1-(2-(2-Methylindol-2-yl)ethyl)-4-phenylpiperazine
2-Methyl-3-(2-(4-phenyl-1-piperazinyl)ethyl)indole
2-Methyl-3-(2-(4-phenyl-1-piperazinyl)ethyl)-1H-indole
1H-Indole, 2-methyl-3-(2-(4-phenyl-1-piperazinyl)ethyl)-
DTXSID60194136
5-23-03-00067 (Beilstein Handbook Reference)
INDOLE, 2-METHYL-3-(2-(4-PHENYL-1-PIPERAZINYL)ETHYL)-
2-Methyl-3-[2-(4-phenyl-1-piperazinyl)ethyl]-1H-indole
DTXCID70116627
1H-Indole, 2-methyl-3-(2-(4-phenyl-1-piperazinyl)ethyl)-(9CI)
2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole
SCHEMBL11333760