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2-Methyl-6-hydroxy-3,4-dihydroisoquinoline

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Identification
Molecular formula
C10H13NO
CAS number
72341-98-1
IUPAC name
2-methyl-3,4-dihydro-1H-isoquinolin-6-ol
State
State

At room temperature, 2-Methyl-6-hydroxy-3,4-dihydroisoquinoline exists in a solid state, typically as a crystalline powder.

Melting point (Celsius)
78.00
Melting point (Kelvin)
351.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
161.21g/mol
Molar mass
161.2050g/mol
Density
1.1432g/cm3
Appearence

2-Methyl-6-hydroxy-3,4-dihydroisoquinoline appears as a crystalline solid. It is typically white or off-white in color and may have a slight odor.

Comment on solubility

Solubility of 2-methyl-3,4-dihydro-1H-isoquinolin-6-ol

The solubility of 2-methyl-3,4-dihydro-1H-isoquinolin-6-ol can be quite intriguing and varies under different conditions. In general, this compound exhibits:

  • Moderate solubility in organic solvents such as ethanol and methanol.
  • Low solubility in water, which can be attributed to its aromatic structure that tends to be hydrophobic.

Factors influencing solubility include:

  1. Temperature: An increase in temperature often leads to higher solubility in organic solvents.
  2. pH levels: Solubility can also be affected by the pH of the solvent, as ionization may enhance solubility in specific environments.
  3. Presence of co-solvents: Mixing with other solvents can lead to improved solubility characteristics.

To summarize, the solubility of 2-methyl-3,4-dihydro-1H-isoquinolin-6-ol is a pivotal factor to consider in various applications, making it essential to understand the context in which it is being utilized. Its moderate affinity for organic solvents compared to its limited solubility in water highlights the necessity for tailored approaches in solvation and formulation strategies.

Interesting facts

Interesting Facts About 2-Methyl-3,4-dihydro-1H-isoquinolin-6-ol

2-Methyl-3,4-dihydro-1H-isoquinolin-6-ol is a fascinating compound that resides within the extensive class of isoquinolines, which are known for their diverse biological activities. Here are some intriguing aspects of this compound:

  • Structural Significance: The isoquinoline scaffold is prevalent in many natural products and biologically active compounds, which highlights the structural importance of 2-methyl-3,4-dihydro-1H-isoquinolin-6-ol in medicinal chemistry.
  • Pharmacological Potential: Compounds related to isoquinolines often exhibit various pharmacological properties, including antimicrobial, anti-inflammatory, and anti-cancer activities. Researchers are investigating 2-methyl-3,4-dihydro-1H-isoquinolin-6-ol for potential therapeutic uses.
  • Synthesis Pathways: The synthesis of 2-methyl-3,4-dihydro-1H-isoquinolin-6-ol can involve complex synthetic pathways, which inspire chemists to explore innovative methods and reactions that lead to the creation of this compound.
  • Historical Context: Isoquinoline derivatives have been studied since the early 19th century, and the ongoing research into compounds like 2-methyl-3,4-dihydro-1H-isoquinolin-6-ol continues to reveal their importance in both historical and modern contexts in the field of chemistry.

As science progresses, the functionalities and mechanisms of compounds such as 2-methyl-3,4-dihydro-1H-isoquinolin-6-ol may unveil further applications, illustrating the ever-evolving relationship between chemical structures and their biological implications. In the words of renowned chemist Robert H. Grubbs, "Science is a way of thinking much more than it is a body of knowledge." This compound stands as a testament to that philosophy.

Synonyms
14097-39-3
2-Methyl-1,2,3,4-tetrahydroisoquinolin-6-ol
1,2,3,4-Tetrahydro-2-methyl-6-isoquinolinol
2-methyl-3,4-dihydro-1H-isoquinolin-6-ol
6-ISOQUINOLINOL, 1,2,3,4-TETRAHYDRO-2-METHYL-
MFCD01444792
Longimammosine
BRN 0004403
CHEMBL5093214
SCHEMBL12158830
DTXSID10161510
BMLTXAQSFDCMHA-UHFFFAOYSA-N
AKOS004907208
DA-10554
DS-16089
SY110837
CS-0047256
F14525
2-Methyl-1,2,3,4-tetrahydro-6-isoquinolinol #
N-Methyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline