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Ketoconazole

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Identification
Molecular formula
C26H28Cl2N4O4
CAS number
65277-42-1
IUPAC name
2-methyl-4-(2,2,2-trichloro-1-hydroxy-ethoxy)pentan-2-ol
State
State

At room temperature, ketoconazole is in solid form. It typically comes as a white to off-white crystalline powder. It is stable under normal temperatures and pressures but should be kept in a tightly closed container, protected from light, and stored at controlled room temperatures.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
216.00
Boiling point (Kelvin)
489.15
General information
Molecular weight
531.44g/mol
Molar mass
531.4390g/mol
Density
1.2740g/cm3
Appearence

Ketoconazole typically appears as a white to off-white crystalline powder. It is mostly odorless or may have a slight odor. The powder is usually quite fine and can be found in the crystalline form for pharmaceutical use.

Comment on solubility

Solubility of 2-methyl-4-(2,2,2-trichloro-1-hydroxy-ethoxy)pentan-2-ol

The solubility of 2-methyl-4-(2,2,2-trichloro-1-hydroxy-ethoxy)pentan-2-ol in various solvents presents an interesting profile due to its unique molecular structure. Understanding its solubility is crucial for applications in chemical formulations, particularly in solvent and surfactant roles. Here are some key points to consider:

  • Polarity: The presence of the trichloro-ethoxy group contributes to its overall polarity, affecting its solubility in polar vs. nonpolar solvents.
  • Hydroxyl Group Influence: The hydroxy (-OH) group typically increases solubility in polar solvents such as water, due to hydrogen bonding.
  • Environmental Considerations: Solubility in organic solvents can be more substantial, which has implications for environmental persistence and behavior.
  • Temperature Effects: Like many organic compounds, solubility is likely to increase with temperature, which can be critical in process optimization.

As such, dense formulations of this compound may exhibit variable solubility characteristics based on the medium. For practical uses, it is often beneficial to conduct empirical solubility tests under diverse conditions to better evaluate the behavior in relevant environments.

Interesting facts

Interesting Facts about 2-methyl-4-(2,2,2-trichloro-1-hydroxy-ethoxy)pentan-2-ol

As a chemical compound, 2-methyl-4-(2,2,2-trichloro-1-hydroxy-ethoxy)pentan-2-ol is noteworthy for several reasons:

  • Utility in Research: This compound is often explored in the context of organic chemistry and materials science. Its unique structure allows for various applications in reaction mechanisms and synthesis routes.
  • Environmental Impact: The presence of trichloro groups in the compound raises interest in environmental chemistry. Halogenated compounds are often scrutinized for their potential effects on ecosystems.
  • Synthesis Study: The synthesis of this compound can serve as an excellent tutorial piece for chemistry students learning about nucleophilic substitution reactions, highlighting the role of sterics in reaction pathways.
  • Biological Activity: Compounds that contain hydroxyl groups, such as this one, are often explored for their biological activity. Research may uncover interesting interactions with biological systems that could have pharmaceutical significance.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." Exploring compounds like 2-methyl-4-(2,2,2-trichloro-1-hydroxy-ethoxy)pentan-2-ol can lead to unexpected discoveries and innovations in chemistry.

As a valuable component for academic exploration, studying this compound not only broadens one's understanding of organic chemistry but also reinforces the multitude of variables that influence chemical properties and reactions.

Synonyms
Chloralodol
CHLORHEXADOL
Mecoral
3563-58-4
Cloralodol
Chloralodol [INN]
Chloralodolum
Cloralodol [INN-Spanish]
Chloralodolum [INN-Latin]
EINECS 222-634-9
UNII-W8RD4N93R2
Chloralodol (INN)
CHLORHEXADOL [MI]
CHLORALODOL [MART.]
CHLORALODOL [WHO-DD]
DTXSID8022795
Cloralodol (INN-Spanish)
Chloralodolum (INN-Latin)
CHLORALODOL (MART.)
DTXCID302795
N05CC02
222-634-9
Mechloral
2-Methyl-4-(2,2,2-trichloro-1-hydroxyethoxy)pentan-2-ol
W8RD4N93R2
Lora
Medodorm
DEA No. 2510
SCHEMBL148160
CHEMBL2104116
CHEBI:135097
QVFWZNCVPCJQOP-UHFFFAOYSA-N
DB01534
NS00029892
D07325
Q5102911
2-methyl-4-[(2,2,2-trichloro-1-hydroxyethyl)oxy]pentan-2-ol