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Nitrazepam

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Identification
Molecular formula
C15H11N3O3
CAS number
146-22-5
IUPAC name
2-methyl-5-nitroso-6a,7,8,9,10,12-hexahydro-6H-pyrido[2,1-c][1,4]benzodiazepine
State
State

At room temperature, nitrazepam is a solid. It is usually found in powder form for medicinal use.

Melting point (Celsius)
227.00
Melting point (Kelvin)
500.15
Boiling point (Celsius)
355.00
Boiling point (Kelvin)
628.15
General information
Molecular weight
282.27g/mol
Molar mass
282.2710g/mol
Density
1.4609g/cm3
Appearence

Nitrazepam typically appears as a white to pale yellow crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 2-methyl-5-nitroso-6a,7,8,9,10,12-hexahydro-6H-pyrido[2,1-c][1,4]benzodiazepine

The solubility of 2-methyl-5-nitroso-6a,7,8,9,10,12-hexahydro-6H-pyrido[2,1-c][1,4]benzodiazepine is a complex topic due to its unique structure and functional groups.

Generally, this compound exhibits moderate to low solubility in aqueous solutions, influenced by several factors, including:

  • Polarity: The presence of the nitroso group may slightly increase the polarity of the molecule, impacting its solubility in polar solvents.
  • Hydrophobicity: The hydrocarbon rings tend to render the compound more hydrophobic, reducing solubility in water.
  • pH Sensitivity: Solubility can vary with changes in pH, as protonation of certain groups can enhance interaction with solvents.

Moreover, when considering the solubility metrics, it’s important to reference parameters such as:

  • Solubility Product (Ksp): Critical for understanding equilibrium in saturated solutions.
  • Log P (Partition Coefficient): An indicator of the compound's distribution between lipophilic and hydrophilic phases.

In summary, the solubility of this compound can be characterized as limited in water but may exhibit better solubilization in organic solvents such as:

  • DMSO (Dimethyl Sulfoxide)
  • EtOH (Ethanol)
  • Acetone

Further studies including experimental solubility tests are necessary to definitively characterize its behavior in various solvents.

Interesting facts

Interesting Facts about 2-Methyl-5-nitroso-6a,7,8,9,10,12-hexahydro-6H-pyrido[2,1-c][1,4]benzodiazepine

The compound known as 2-methyl-5-nitroso-6a,7,8,9,10,12-hexahydro-6H-pyrido[2,1-c][1,4]benzodiazepine exhibits a fascinating structure that places it in the realm of benzodiazepines, a class of compounds known for their psychoactive properties. Here are some interesting insights regarding this compound:

  • Structural Complexity: This molecule features a unique fusion of a pyridine and benzodiazepine ring. The combination results in a versatile compound with potential applications in pharmacology.
  • Potential Biological Activity: Compounds similar to this one have been studied for their potential in treating various conditions such as anxiety, insomnia, and seizures. Investigating their mechanisms can provide valuable insights into how they interact with the central nervous system.
  • Nitroso Group Significance: The presence of the nitroso group (–NO) introduces distinct reactivity patterns and can influence the compound’s biological activity. This modification can alter how the compound interacts with biological targets.
  • Research Interest: Scientists are intrigued by the potential derivatives of this compound, exploring ways to modify its structure to enhance efficacy or reduce side effects. As stated by a researcher, "The path to discovering therapeutic agents can often lie within the intricacies of their molecular architecture."

Understanding compounds like 2-methyl-5-nitroso-6a,7,8,9,10,12-hexahydro-6H-pyrido[2,1-c][1,4]benzodiazepine not only aids in drug development but also deepens our understanding of chemical interactions and medicinal chemistry.

Synonyms
2-methyl-5-nitroso-6a,7,8,9,10,12-hexahydro-6H-pyrido[2,1-c][1,4]benzodiazepine
4927-69-9
DTXSID90274692