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Nitrofurantoin monohydrate

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Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
2-morpholin-4-ium-4-yl-N-[(5-nitro-2-furyl)methyleneamino]acetamide;chloride
State
State

At room temperature, nitrofurantoin is a solid. It is stable and does not evaporate or change state under typical room conditions.

Melting point (Celsius)
245.00
Melting point (Kelvin)
518.15
Boiling point (Celsius)
262.80
Boiling point (Kelvin)
535.95
General information
Molecular weight
238.16g/mol
Molar mass
238.1560g/mol
Density
1.6820g/cm3
Appearence

Nitrofurantoin is typically a yellow crystalline solid. It has a characteristic yellow-green hue, which can be visually striking depending on the crystal size and purity. It may also appear slightly brownish in its less pure form.

Comment on solubility

Solubility of 2-morpholin-4-ium-4-yl-N-[(5-nitro-2-furyl)methyleneamino]acetamide;chloride

The solubility of 2-morpholin-4-ium-4-yl-N-[(5-nitro-2-furyl)methyleneamino]acetamide;chloride is influenced by several factors, making it a compound of considerable interest in chemistry.

Key Points on Solubility:

  • Solvent Type: This compound is generally more soluble in polar solvents such as water and alcohols due to its ionic structure.
  • pH Levels: The solubility may vary with changes in pH, as the protonation state of the morpholine group can affect its ionization.
  • Temperature: Increased temperature typically enhances solubility, so this compound may exhibit better solubility at elevated temperatures.
  • Concentration Effects: At higher concentrations, interactions between solute molecules can lead to precipitation, indicating a limit to solubility.

In summary, the solubility of this compound is context-dependent and is influenced by factors such as solvent choice, pH, temperature, and concentration. Understanding these aspects can assist researchers in effectively utilizing this compound in various applications.

Interesting facts

Interesting Facts About 2-Morpholin-4-ium-4-yl-N-[(5-nitro-2-furyl)methyleneamino]acetamide;chloride

The compound 2-morpholin-4-ium-4-yl-N-[(5-nitro-2-furyl)methyleneamino]acetamide;chloride is a fascinating example in the realm of medicinal chemistry. This compound exhibits a unique structure that contributes to its potential biological activity, particularly as an antimicrobial agent.

Key Attributes

  • Complex Structure: This compound features a morpholinium moiety, which is integral in enhancing solubility and biological availability in various environments.
  • Furyl Nitro Group: The presence of the nitro-2-furyl group can influence the compound's electronic properties, possibly leading to improved reactivity with biological targets.
  • Potential Applications: Due to its structural characteristics, researchers are interested in its efficacy against a variety of pathogens. Studies suggest it may play a role in developing new antibiotics.

Research Insights

Recent studies have shown that derivatives of this compound can exhibit selective toxicity against certain cancer cell lines while sparing normal cells, showcasing its therapeutic potential. Additionally, the mechanism of action may involve:

  1. Inhibition of key enzymes within microbial cells.
  2. Disruption of bacterial cell wall synthesis.
  3. Interference with nucleic acid synthesis pathways.

As a member of a class of compounds known for their biological activity, 2-morpholin-4-ium-4-yl-N-[(5-nitro-2-furyl)methyleneamino]acetamide;chloride continues to attract interest in synthetic and medicinal chemistry. Its exploration could yield new frontiers in pharmacological research—an exciting prospect for any aspiring chemist!