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Diphenhydramine

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Identification
Molecular formula
C17H21NO2
CAS number
58-73-1
IUPAC name
2-morpholinoethyl 2-hydroxy-2,2-diphenyl-acetate
State
State

At room temperature, diphenhydramine is in a solid state. It can be processed into tablets, capsules, or liquid forms for medicinal use. As a solid, it is stable and typically stored at room temperature in a dry environment.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
211.00
Boiling point (Kelvin)
484.15
General information
Molecular weight
255.34g/mol
Molar mass
255.3430g/mol
Density
1.0932g/cm3
Appearence

Diphenhydramine is typically encountered as a white, crystalline powder. It is often observed in solid form, though it can be compounded into liquid form for pharmaceutical use. Its appearance can be altered slightly depending on the form it is made into, such as tablets or capsules, where it may be combined with other substances.

Comment on solubility

Solubility of 2-morpholinoethyl 2-hydroxy-2,2-diphenyl-acetate

The solubility of 2-morpholinoethyl 2-hydroxy-2,2-diphenyl-acetate in various solvents is a noteworthy aspect due to its unique chemical structure. Generally, the solubility of this compound can be assessed based on the presence of functional groups and its molecular interactions. Here are some key points regarding its solubility:

  • Polar Solvents: This compound tends to have better solubility in polar solvents such as water and alcohols. The presence of the 2-hydroxy group facilitates hydrogen bonding, enhancing solubility.
  • Non-Polar Solvents: Solubility in non-polar solvents may be limited. The substantial phenyl groups present in the structure can hinder solubility in less polar media.
  • Temperature Dependence: As with many organic compounds, solubility may vary significantly with temperature. Increasing temperature can often lead to increased solubility.
  • pH Dependence: Due to the presence of the morpholino group, the solubility may also be influenced by the pH of the solution, potentially impacting its ionization state.

In conclusion, the solubility of 2-morpholinoethyl 2-hydroxy-2,2-diphenyl-acetate can be described as:

  • Moderate in polar solvents
  • Poor in non-polar solvents
  • Variable with temperature and pH

Understanding these solubility characteristics is vital for applications in pharmaceuticals and related fields where solubility plays a crucial role in bioavailability and efficacy.

Interesting facts

Interesting Facts about 2-morpholinoethyl 2-hydroxy-2,2-diphenyl-acetate

2-morpholinoethyl 2-hydroxy-2,2-diphenyl-acetate is a fascinating compound that belongs to the class of organic esters. Here are some engaging facts about this compound:

  • Pharmaceutical Relevance: This compound has garnered interest in pharmacological applications, particularly as a potential therapeutic agent due to its good bioavailability.
  • Synthesis Methods: The synthesis of 2-morpholinoethyl 2-hydroxy-2,2-diphenyl-acetate often involves multi-step organic reactions, making it an exciting subject for organic chemists who enjoy challenges in synthesis.
  • Unique Structure: The presence of both hydroxy and diphenyl groups in its structure contributes to its intriguing chemical properties, leading to diverse applications ranging from materials science to medicinal chemistry.
  • Biological Activity: Investigations into the biological activity of this compound have shown that it can exhibit potent activity against certain types of biological targets, which could lead to the development of new drugs.
  • Research Potential: As a compound of interest, it provides a rich avenue for further research within both the chemical and biomedical fields, especially for students and researchers looking to explore new frontiers in medicinal chemistry.

In conclusion, 2-morpholinoethyl 2-hydroxy-2,2-diphenyl-acetate stands as a noteworthy compound, bridging the gap between organic synthesis and practical applications in medicine.