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Amiodarone hydrochloride

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Identification
Molecular formula
C25H29ClN2O5
CAS number
19774-82-4
IUPAC name
2-(N-[2-(4-butoxyphenoxy)acetyl]-3-ethoxy-anilino)ethyl-diethyl-ammonium;chloride
State
State

Amiodarone hydrochloride is generally found in a solid state at room temperature. It is stable under recommended storage conditions and can be readily formulated for pharmaceutical use.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.20
Boiling point (Celsius)
402.10
Boiling point (Kelvin)
675.30
General information
Molecular weight
681.77g/mol
Molar mass
681.7740g/mol
Density
1.2250g/cm3
Appearence

Amiodarone hydrochloride typically appears as a white or almost white powder. It may have a slightly crystalline texture and is often very fine to the touch.

Comment on solubility

Solubility of 2-(N-[2-(4-butoxyphenoxy)acetyl]-3-ethoxy-anilino)ethyl-diethyl-ammonium; chloride

The solubility of 2-(N-[2-(4-butoxyphenoxy)acetyl]-3-ethoxy-anilino)ethyl-diethyl-ammonium; chloride can be characterized based on its unique chemical structure and composition. Here are some important points to consider:

  • Water Solubility: Given its quaternary ammonium nature, this compound is likely to be more soluble in water compared to non-polar organic solvents. The positively charged ammonium group can interact favorably with water molecules.
  • Organic Solvent Solubility: The presence of long hydrophobic chains (such as the butoxy and ethoxy groups) suggests that the compound may also show significant solubility in non-polar organic solvents, making it versatile in various solvent systems.
  • Temperature Dependence: Like many ionic compounds, its solubility may increase with temperature. Thus, elevated temperatures could enhance the dissolution process.
  • pH Effects: The solubility may also be influenced by the pH of the solution, as changes in acidity can affect the ionization of the ammonium group.

In summary, the solubility of 2-(N-[2-(4-butoxyphenoxy)acetyl]-3-ethoxy-anilino)ethyl-diethyl-ammonium; chloride is influenced by its unique structural features, making it soluble in both aqueous and organic environments, with factors such as temperature and pH playing significant roles in its solubility behavior.

Interesting facts

Interesting Facts about 2-(N-[2-(4-butoxyphenoxy)acetyl]-3-ethoxy-anilino)ethyl-diethyl-ammonium; chloride

This compound is a fascinating example of a quaternary ammonium salt, highlighting the intricate interplay between organic chemistry and pharmaceuticals. Quaternary ammonium compounds, such as this one, are often noted for their wide range of applications. Here are some remarkable insights:

  • Pharmaceutical Potential: Compounds like this often exhibit antimicrobial properties, making them valuable in the development of new medications and formulations.
  • Drug Delivery Systems: The presence of multiple functional groups provides versatility for drug delivery systems, enhancing the solubility and bioavailability of therapeutic agents.
  • Structure-Activity Relationship: The structural complexity allows researchers to study the relationship between the molecular structure and its biological activity, an essential concept in medicinal chemistry.
  • Ion Exchange Properties: As a quaternary ammonium salt, it may engage in ion exchange reactions, useful in various applications like water treatment and separation processes.

Moreover, this compound's synthesis typically involves multi-step reactions, showcasing the importance of precision in organic synthesis. The incorporation of substituents such as 4-butoxyphenoxy groups enhances its hydrophobic characteristics, influencing its pharmacokinetics and overall efficacy in biological systems.

As one noted chemist stated, "The beauty of chemistry lies in its ability to combine simplicity with complex functions, creating compounds that can change lives." This compound is a testament to that statement, illustrating the potential that lies within the realm of chemical science.


Synonyms
2-(p-Butoxyphenoxy)-N-(2-(diethylamino)ethyl)-m-acetophenetidide hydrochloride
RefChem:351474
27471-62-1
m-Acetophenetidide, 2-(p-butoxyphenoxy)-N-(2-(diethylamino)ethyl)-, monohydrochloride
2-(4-butoxyphenoxy)-N-[2-(diethylamino)ethyl]-N-(3-ethoxyphenyl)acetamide;hydrochloride