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Diphenhydramine

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Identification
Molecular formula
C17H21NO
CAS number
58-73-1
IUPAC name
2-(N-[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]anilino)ethyl-trimethyl-ammonium
State
State

Diphenhydramine is typically found as a solid at room temperature.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
377.00
Boiling point (Kelvin)
650.15
General information
Molecular weight
291.82g/mol
Molar mass
291.8220g/mol
Density
1.0140g/cm3
Appearence

Diphenhydramine is a white, crystalline compound.

Comment on solubility

Solubility of 2-(N-[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]anilino)ethyl-trimethyl-ammonium

The solubility of 2-(N-[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]anilino)ethyl-trimethyl-ammonium can be influenced by several factors due to its complex structure. Generally, quaternary ammonium compounds like this one tend to exhibit good solubility in polar solvents, particularly in:

  • Water - Due to the presence of charged quaternary ammonium groups.
  • Alcohols - Such as ethanol or methanol, which can improve solubility further.
  • Aqueous solutions - Particularly in buffered systems.

However, its solubility may be affected by:

  1. Temperature - Increased temperatures often enhance solubility.
  2. pH of the solution - Alterations in pH may influence the ionization state of certain functional groups.
  3. Presence of other ions - Ions in the solution can alter solubility through ion-dipole interactions.

In summary, the solubility of this compound is characterized by its ability to dissolve well in polar environments while being sensitive to changes in temperature, pH, and ionic strength. As such, understanding these properties is essential for its application in various fields, where solvation plays a critical role.

Interesting facts

Interesting Facts about 2-(N-[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]anilino)ethyl-trimethyl-ammonium

This fascinating compound is a derivative of ammonium salt, showcasing a rather complex molecular architecture that highlights the versatility of organic synthesis. Here are some intriguing facts:

  • Functional Groups Galore: The compound features multiple functional groups, including a trimethyl ammonium moiety and a phenolic hydroxyl group, making it a candidate for various biochemical applications.
  • Potential Biological Applications: Due to the presence of thienyl and phenyl units, this compound may exhibit significant pharmacological properties, potentially acting as a ligand in various biosystems or as a precursor in drug design.
  • Synergistic Effects: The incorporation of both thienyl and phenyl groups can lead to enhanced activity mechanisms in organic reactions or interactions with biological targets, indicating a possible area for research into synergistic effects of compound combinations.
  • Structure-Activity Relationship: Chemists often utilize compounds like this in the study of structure-activity relationships (SAR). Variations in substituents could unravel insights into their biological mechanisms and lead to the development of new therapeutics.
  • Legacy in Research: Compounds with similar structures have historically contributed to breakthroughs in medicinal chemistry. Their complex arrangements provide rich opportunities for exploration in drug discovery.

Overall, 2-(N-[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]anilino)ethyl-trimethyl-ammonium embodies an intricate marriage of different chemical realms, inviting scientists to delve deeper into its properties and potential uses. As the renowned chemist Linus Pauling said, "The best way to have a good idea is to have a lot of ideas." This is precisely what makes the study of such compounds exhilarating!