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Atazanavir

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Identification
Molecular formula
C38H52N6O7
CAS number
198904-31-3
IUPAC name
2-[N'-(4-chlorophenyl)carbamimidoyl]-1-isopropyl-1-methyl-guanidine
State
State

At room temperature, atazanavir exists as a solid. It is typically used in the form of its sulfate salt to improve water solubility.

Melting point (Celsius)
213.50
Melting point (Kelvin)
486.65
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
705.87g/mol
Molar mass
705.8650g/mol
Density
1.1060g/cm3
Appearence

Atazanavir is typically found as a white to pale yellow crystalline powder. It is slightly soluble in water but more soluble in ethanol and methanol.

Comment on solubility

Solubility of 2-[N'-(4-chlorophenyl)carbamimidoyl]-1-isopropyl-1-methyl-guanidine

The solubility of 2-[N'-(4-chlorophenyl)carbamimidoyl]-1-isopropyl-1-methyl-guanidine is an intriguing characteristic that can be critical for its applications. Solubility largely depends on the following factors:

  • Molecular Structure: The presence of polar functional groups can enhance solubility in polar solvents.
  • Temperature: Generally, solubility increases with temperature, particularly for solid compounds.
  • pH Sensitivity: Compounds containing amine or guanidine groups may have pH-dependent solubility.

In the case of this compound, it is essential to note:

  1. High solubility in organic solvents due to its bulky isopropyl and aryl groups.
  2. Limited aqueous solubility might be affected by the presence of the 4-chlorophenyl substitution.

Thus, understanding the solubility behavior is key to optimizing its usage in various formulations. An insightful approach to study its solubility in different solvents will be essential, as solubility is not just a physical property, but a dynamic interplay of chemistry!

Interesting facts

Interesting Facts about 2-[N'-(4-chlorophenyl)carbamimidoyl]-1-isopropyl-1-methyl-guanidine

This compound, known for its intriguing structure and biological applications, showcases the fascinating world of guanidine derivatives. Here are some notable facts:

  • Guanidine Framework: As a derivative of guanidine, this compound features a unique arrangement of nitrogen-rich functional groups, which contributes to its reactivity and versatility in chemical reactions.
  • Biological Relevance: Compounds like this one often possess significant pharmacological potential, targeting various biological pathways. They may serve as ligands for receptors or enzymes, hinting at their roles in medicinal chemistry.
  • Chlorophenyl Group: The presence of a chlorophenyl moiety introduces unique electronic properties and steric effects, influencing the compound's interaction with biological targets and enhancing its efficacy.
  • Synthesis: The synthesis of this compound can involve multi-step organic reactions, often requiring careful manipulation of reagents and conditions to ensure the desired configuration is achieved.
  • Research Potential: Given its complexity, this compound presents opportunities for research in both academic and industrial settings, including drug development and materials science.

In the words of a renowned chemist, "The beauty of chemistry lies not only in creating compounds but in understanding their intricate dances within biological systems." This compound exemplifies that beauty, representing a small piece of the vast puzzle of life at a molecular level.


Overall, from its structural complexity to potential applications, 2-[N'-(4-chlorophenyl)carbamimidoyl]-1-isopropyl-1-methyl-guanidine stands as an exciting subject for further exploration in the field of chemistry.