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Lidocaine

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Identification
Molecular formula
C14H22N2O2
CAS number
137-58-6
IUPAC name
2-(N-acetyl-4-ethoxy-anilino)-N,N-dimethyl-acetamide
State
State

Lidocaine is typically found in a solid crystalline state at room temperature. It is often used in solution form in medicine.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.80
Boiling point (Kelvin)
623.95
General information
Molecular weight
234.34g/mol
Molar mass
234.3410g/mol
Density
0.9940g/cm3
Appearence

Lidocaine appears as a white to slightly yellowish crystalline powder. It is odorless or has a faint characteristic odor. It is often used in its hydrochloride form for medical applications.

Comment on solubility

Solubility of 2-(N-acetyl-4-ethoxy-anilino)-N,N-dimethyl-acetamide

The solubility of 2-(N-acetyl-4-ethoxy-anilino)-N,N-dimethyl-acetamide in various solvents can be characterized by the following observations:

  • Polar Solvents: This compound tends to show a degree of solubility in polar solvents such as water and alcohols. The presence of the ethoxy and acetamide functional groups enhances its ability to form hydrogen bonds, which aids in solubilization.
  • Non-Polar Solvents: In terms of non-polar solvents, the solubility is generally lower. This is largely due to the hydrophilic nature of the compound's functional groups, which do not interact favorably with non-polar solvents.
  • Concentration Effects: The solubility may vary with concentration, so experimenting with different concentrations in solvents is advisable for optimizing the solubility.

In summary, it is essential to consider the solvent environment when evaluating the solubility of this specific compound. The ability to dissolve effectively can significantly depend on the chemical characteristics of the solvent used. As a rule of thumb, you can remember that:
"Like dissolves like."

Interesting facts

Interesting Facts about 2-(N-acetyl-4-ethoxy-anilino)-N,N-dimethyl-acetamide

2-(N-acetyl-4-ethoxy-anilino)-N,N-dimethyl-acetamide is a fascinating compound with diverse applications in both the pharmaceutical and chemical industries. Here are some notable aspects:

  • Pharmaceutical Significance: This compound exhibits potential as a pharmaceutical intermediate, aiding in the synthesis of various medicinal compounds.
  • Structure and Function: The compound contains multiple functional groups that contribute to its reactivity and biological activity, making it an intriguing subject for further research.
  • Research Interest: Its unique structure may influence its biological properties, which has piqued the interest of researchers looking to explore its applications in drug development.
  • Ethoxy Group: The inclusion of the ethoxy substituent is particularly notable, as it can enhance solubility and modify the compound's lipophilicity, which is essential for its absorption and distribution in biological systems.
  • Potential Market Applications: Due to its intermediacy, this compound may play a pivotal role in the manufacture of various active pharmaceutical ingredients (APIs).

As we delve deeper into the field of medicinal chemistry, compounds like 2-(N-acetyl-4-ethoxy-anilino)-N,N-dimethyl-acetamide exemplify how chemical modifications can lead to significant advances in drug formulations. The exploration of such compounds not only enhances our understanding of structure-activity relationships but also opens up new avenues for therapeutic discovery.

Synonyms
3736-41-2
GB-302
BRN 2813091
Acetamide, 2-(acetyl-(4-ethoxyphenyl)amino)-N,N-dimethyl-
DTXSID50190804
DTXCID50113295
Acetamide, 2-(acetyl-(4-ethoxyphenyl)amino)-N,N-dimethyl-(9CI)
nuoiccvqbncnih-uhfffaoysa-n
N-((Dimethylcarbamoyl)methyl)-p-acetophenetidide
p-ACETOPHENETIDIDE, N-((DIMETHYLCARBAMOYL)METHYL)-
2-(N-acetyl-4-ethoxyanilino)-N,N-dimethylacetamide
Acetamide, 2-(acetyl-(4-ethoxyphenyl)amino)-N,N-dimethyl- (9CI)