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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
2-(N-acetylanilino)-N,N-dimethyl-acetamide
State
State

At room temperature, lidocaine is typically found as a solid. It is stable under normal conditions, but can be processed into various dosage forms for different medical uses.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
234.34g/mol
Molar mass
234.3370g/mol
Density
1.0260g/cm3
Appearence

Lidocaine is typically encountered as a white crystalline powder. It is odorless and has a slightly bitter taste. It can be formulated in various forms for medicinal applications, including gels, sprays, and lotions.

Comment on solubility

Solubility of 2-(N-acetylanilino)-N,N-dimethyl-acetamide

2-(N-acetylanilino)-N,N-dimethyl-acetamide, commonly referred to as a derivative of acetamide and characterized by its distinctive structure, exhibits intriguing solubility properties.

In terms of solubility:

  • Solvent Interaction: This compound is generally soluble in polar solvents such as water, methanol, and ethanol due to the presence of its amide functional groups that can engage in hydrogen bonding.
  • Non-Polar Solvent Solubility: It tends to have limited solubility in non-polar solvents like hexane or benzene, which is typical for compounds with significant polar characteristics.
  • Temperature Dependence: Like many organic compounds, its solubility may increase with rising temperature, allowing for greater dissolution in solvents.

To summarize, the solubility of 2-(N-acetylanilino)-N,N-dimethyl-acetamide can be described as:
“High in polar solvents, low in non-polar solvents.” This insight into solubility can guide practical applications and further research in various chemical environments.

Interesting facts

Interesting Facts about 2-(N-acetylanilino)-N,N-dimethyl-acetamide

2-(N-acetylanilino)-N,N-dimethyl-acetamide, often referred to in the scientific community as a versatile organic compound, exhibits a range of fascinating properties and applications. Below are several points that highlight its significance:

  • Role in Organic Synthesis: This compound is widely utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, demonstrating its importance in the development of medicinal chemistry.
  • Structure and Function: The presence of both an acetylanilino and dimethylacetic moiety in its structure allows for unique reactivity patterns, making it an excellent candidate for various chemical reactions.
  • Potential as a Solvent: Due to its polar nature, it can function effectively as a solvent in reactions involving polar compounds, which is essential in many organic synthesis processes.
  • Biological Relevance: Research has indicated that compounds similar to this one may exhibit biological activity, making them of interest in pharmacological studies for their potential therapeutic effects.
  • Cross-Linking Agent: This compound may also serve as a cross-linking agent in the formation of polymeric materials, providing enhanced stability and performance in various applications.

As the world of chemistry continues to expand, 2-(N-acetylanilino)-N,N-dimethyl-acetamide remains an intriguing compound, bridging gaps between synthetic chemistry and practical applications. Its multifaceted nature offers endless exploration opportunities in academic and industrial research.

Synonyms
Phenylacetylglycine dimethylamide
Ralgin
3738-06-5
2-(N-acetylanilino)-N,N-dimethylacetamide
N-((Dimethylcarbamoyl)methyl)acetanilide
GB-105
Acetamide, 2-(acetylphenylamino)-N,N-dimethyl-
N-Phenyl-N-acetylglycine dimethylamide
Phenylacetylglycine dimethylamide [JAN]
ACETANILIDE, N-((DIMETHYLCARBAMOYL)METHYL)-
BRN 2808578
7TUY98X69L
2-(Acetylphenylamino)-N,N-dimethylacetamide
DTXSID8057726
CHEBI:31993
Phenylacetylglycine dimethylamide (JAN)
UNII-7TUY98X69L
SCHEMBL6056919
CHEMBL3184273
DTXCID9031515
KEVKBVWYVMVEBG-UHFFFAOYSA-N
Tox21_113711
AKOS033243940
NCGC00249935-01
CAS-3738-06-5
2-(Acetylanilino)-N,N-dimethylacetamide #
2-(N-acetylanilino)-N,N-dimethyl-acetamide
D01508
PHENYLACETYLGLYCINE DIMETHYLAMIDE [WHO-DD]
Q27114745
Z1310028058