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2-nitro-4-(trifluoromethyl)phenol

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Identification
Molecular formula
C7H4F3NO3
CAS number
393-11-3
IUPAC name
2-nitro-4-(trifluoromethyl)phenol
State
State

At room temperature, 2-nitro-4-(trifluoromethyl)phenol is in a solid state. Its appearance as a solid makes it relatively easy to handle and weigh for various chemical applications. As with many similar aromatic compounds, it should be stored properly to maintain its stability over time.

Melting point (Celsius)
104.00
Melting point (Kelvin)
377.00
Boiling point (Celsius)
284.00
Boiling point (Kelvin)
557.00
General information
Molecular weight
221.11g/mol
Molar mass
221.1260g/mol
Density
1.5900g/cm3
Appearence

The compound 2-nitro-4-(trifluoromethyl)phenol typically appears as a pale yellow solid. It may also be found as yellow crystals. The solid form can be handled and stored like other similar aromatic compounds, under conditions that prevent decomposition or reaction with materials such as strong bases or acids.

Comment on solubility

Solubility of 2-nitro-4-(trifluoromethyl)phenol

2-nitro-4-(trifluoromethyl)phenol, with its complex structure, exhibits some interesting characteristics when it comes to solubility:

  • Solvent Polarity: This compound tends to be more soluble in polar solvents due to the presence of the nitro (−NO₂) and hydroxyl (−OH) groups, which can participate in hydrogen bonding.
  • Hydrophobic Interaction: The trifluoromethyl group (−CF₃) introduces hydrophobic characteristics, which can limit solubility in very polar or aqueous environments.
  • Temperature Effect: Solubility may vary with temperature, often increasing with higher temperatures due to greater kinetic energy overcoming intermolecular forces.

According to studies, while 2-nitro-4-(trifluoromethyl)phenol may dissolve in alcohols and other organic solvents, its solubility in water is relatively low, making it a compound that requires careful consideration when applying it in aqueous-based systems. As a person examining chemical behavior, it's essential to recognize that:

  • Each solvent's unique interactions can significantly affect solubility.
  • Understanding the specific context of use can guide the choice of solvent effectively.

In conclusion, the solubility of 2-nitro-4-(trifluoromethyl)phenol can be characterized as a balance between its polar and non-polar features, making it a versatile compound depending on the environmental conditions.

Interesting facts

Interesting Facts about 2-Nitro-4-(trifluoromethyl)phenol

2-Nitro-4-(trifluoromethyl)phenol, often abbreviated as NTCP, is a fascinating chemical compound with unique properties and applications. Here are some intriguing points about this compound:

  • Dual Functionality: This compound possesses both a nitro group and a trifluoromethyl group, making it highly versatile. The nitro group is known for its electron-withdrawing capability, which enhances the compound's reactivity.
  • Applications in Research: NTCP plays a significant role in the synthesis of various pharmaceuticals and agrochemicals, acting as an intermediate in the development of compounds aimed at improving crop yields.
  • Environmental Considerations: Understanding the properties of NTCP is essential for toxicity studies, as several nitro compounds can exhibit harmful effects on the environment.
  • Fluorinated Compounds: The presence of the trifluoromethyl group contributes to the compound's hydrophobic nature, making it an interesting subject of study in medicinal chemistry and material sciences.

Notable Reactions

As a chemist, one might explore the reactivity of NTCP in various reactions, such as:

  • Nucleophilic Substitution: The electron-withdrawing properties of the nitro group can leave the structure open to nucleophilic attack, leading to new compounds.
  • Reduction Reactions: The nitro group can be selectively reduced, allowing chemists to transform NTCP into other valuable derivatives.

In summary, 2-nitro-4-(trifluoromethyl)phenol is not just a chemical compound; it serves as a gateway to expanding our understanding of chemical interactions and applications in various fields. As the late chemist Robert H. Grubbs once said, "Organic chemistry is the chemistry of life." Indeed, compounds like NTCP are at the heart of this exploration.

Synonyms
2-Nitro-4-(trifluoromethyl)phenol
400-99-7
4-Hydroxy-3-nitrobenzotrifluoride
Phenol, 2-nitro-4-(trifluoromethyl)-
2-Nitro-4-Trifluoromethylphenol
BRN 2215510
EINECS 206-927-9
MFCD00009791
DTXSID6059946
XZEDEVRSUANQEM-UHFFFAOYSA-
2-nitro-4-trifluoromethyl-phenol
4-06-00-02150 (Beilstein Handbook Reference)
2-Nitro-alpha,alpha,alpha-trifluoro-p-cresol
CU9AQU8UAL
p-Cresol, 2-nitro-alpha,alpha,alpha-trifluoro-
SCHEMBL1026402
DTXCID2039704
AKOS005063851
4-TRIFLUOROMETHYL-2-NITROPHENOL
AC-3815
AS-8579
CS-W015280
SB73977
2-Nitro-4-(trifluoromethyl)phenol, 99%
SY016858
DB-023985
N0779
NS00042724
EN300-99178
2-Nitro-.alpha.,.alpha.,.alpha.-trifluoro-p-cresol
p-Cresol, 2-nitro-.alpha.,.alpha.,.alpha.-trifluoro-
Z448245556
206-927-9