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2-Nitrobenzenesulfonyl chloride

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Identification
Molecular formula
C6H4ClNO4S
CAS number
127-48-0
IUPAC name
2-nitrobenzenesulfonyl chloride
State
State
The compound is typically found as a solid at room temperature. It may be handled in its solid form for various chemical synthesis applications.
Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
303.50
Boiling point (Kelvin)
576.65
General information
Molecular weight
221.61g/mol
Molar mass
221.6070g/mol
Density
1.5830g/cm3
Appearence

2-Nitrobenzenesulfonyl chloride is a pale yellow crystalline solid. It is often encountered as a powder or crystalline flakes. The compound is known for its pungent odor, which is typical of sulfonyl chlorides.

Comment on solubility

Solubility of 2-nitrobenzenesulfonyl chloride

2-nitrobenzenesulfonyl chloride, with the chemical formula C6H4ClN1O3S, showcases fascinating solubility characteristics that are important in both organic synthesis and applications in pharmaceuticals.

Key aspects of its solubility include:

  • Polarity: The presence of the nitro group (–NO2) and sulfonyl group (–SO2Cl) introduces significant polarity to the molecule, which enhances its solubility in polar solvents.
  • Solvent Compatibility: 2-nitrobenzenesulfonyl chloride is known to be soluble in:
    • Polar organic solvents such as acetonitrile, dichloromethane, and dimethyl sulfoxide (DMSO).
    • However, it exhibits low solubility in water due to its hydrophobic aromatic ring.
  • Temperature Influence: As with many organic compounds, solubility can improve with an increase in temperature, allowing for better dissolution in chosen solvents.

In practical applications, understanding the solubility behavior of 2-nitrobenzenesulfonyl chloride is crucial for its use in various synthesis reactions, where solubility often influences reaction rates and yields.

Interesting facts

Interesting Facts about 2-Nitrobenzenesulfonyl Chloride

2-Nitrobenzenesulfonyl chloride is an intriguing compound in the field of organic chemistry, primarily due to its reactivity and applications. Here are some engaging points to explore:

  • Versatile Intermediate: This compound serves as a vital intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. Its ability to participate in nucleophilic substitution reactions makes it particularly useful in medicinal chemistry.
  • Functional Group Significance: The nitro group on the aromatic ring enhances electrophilic substitution reactions, facilitating the introduction of other functional groups through further chemical transformations.
  • Handling Caution: As a sulfonyl chloride, it is important to handle this compound with care. It can release toxic gases upon contact with moisture or water, highlighting the importance of using appropriate safety measures in the lab.
  • Innovative Reactivity: 2-Nitrobenzenesulfonyl chloride can be utilized in reactions like amination and acylation. Its unique structure affords researchers the ability to explore new synthetic pathways and develop novel materials.
  • Research Applications: In recent studies, this compound has been investigated for its potential in catalytic processes and polymer chemistry, showcasing its expanding significance beyond traditional uses.

With its notable attributes and broad applicability, 2-nitrobenzenesulfonyl chloride exemplifies the synergy between structure and reactivity in organic synthesis. As we advance in chemical research, compounds like this will continue to pave the way for innovative discoveries and breakthroughs.

Synonyms
2-Nitrobenzenesulfonyl chloride
1694-92-4
o-Nitrophenylsulfonyl chloride
Benzenesulfonyl chloride, 2-nitro-
o-Nitrobenzenesulfonyl chloride
2-Nitrobenzenesulphonyl chloride
Benzenesulfonyl chloride, o-nitro-
P2E4YZ9H2Y
2-nitrophenylsulfonyl chloride
EINECS 216-907-1
NSC 12991
NSC-12991
DTXSID4061888
oNitrophenylsulfonyl chloride
oNitrobenzenesulfonyl chloride
2Nitrobenzenesulphonyl chloride
Benzenesulfonyl chloride, onitro
Benzenesulfonyl chloride, 2nitro
DTXCID3035424
Benzenesulfonyl chloride, onitro (8CI)
Benzenesulfonyl chloride, o-nitro-(8CI)
216-907-1
2-nitrobenzene-1-sulfonyl chloride
2-nitro-benzenesulfonyl chloride
Benzenesulfonyl chloride, nitro-
MFCD00007430
2-Nitrobenzenesulfonylchloride
2-Nitrobenzene-1-sulfonyl Chloride; 2-Nitrobenzenesulfonyl Chloride; 2-Nitrophenylsulfonyl Chloride; NSC 12991; o-Nitrobenzenesulfonyl Chloride; o-Nosyl Chloride
o-Ns-Cl
nitrophenylsulfonyl chloride
UNII-P2E4YZ9H2Y
nitrobenzenesulfonyl chloride
2-nitrophenylsulfonylchloride
nitrophenyl sulfonyl chloride
o-nitrobenzenesulfonylchloride
SCHEMBL17278
2-nitrobenzenesulonyl chloride
2-nitrobenzensulfonyl chloride
2-nitrobenzenesulphonylchloride
o-nitro-benzenesulfonylchloride
o-nitrobenzene sulfonyl chloride
2-nitrobenzene sulfonyl chloride
orthonitrobenzenesulfonyl chloride
SCHEMBL12719300
WPHUUIODWRNJLO-UHFFFAOYSA-
2-Nitro-phenyl-sulphonyl chloride
ortho-nitrobenzenesulfonyl chloride
2-nitrophenylsulphonic acid chloride
NSC12991
2-nitrobenzenesulphonic acid chloride
BBL011343
STL146433
2-Nitrobenzenesulfonyl chloride, 97%
AKOS000120476
FN10727
AS-15956
BP-11755
N0142
NS00025562
EN300-20487
A811112
2-Nitrobenzenesulfonyl chloride, purum, >=98.0% (AT)
F2190-0569
Z104478380
InChI=1/C6H4ClNO4S/c7-13(11,12)6-4-2-1-3-5(6)8(9)10/h1-4H