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2-nitropyridin-3-ol

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Identification
Molecular formula
C5H4N2O3
CAS number
5437-20-3
IUPAC name
2-nitropyridin-3-ol
State
State

2-Nitropyridin-3-ol is a solid at room temperature.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.70
Boiling point (Celsius)
296.50
Boiling point (Kelvin)
569.70
General information
Molecular weight
140.09g/mol
Molar mass
140.1080g/mol
Density
1.4950g/cm3
Appearence

2-Nitropyridin-3-ol appears as a yellow crystalline solid. It is known for its distinct crystalline structure and bright yellow color, which is typical of many nitro compounds.

Comment on solubility

Solubility of 2-nitropyridin-3-ol

2-nitropyridin-3-ol, known for its interesting structural features, exhibits notable solubility characteristics that can influence its applications in various fields. Understanding its solubility is essential for effective usage in chemical processes.

Solubility Insights:

  • Polarity: Due to the presence of a hydroxyl (-OH) group and a nitro (-NO2) group, 2-nitropyridin-3-ol is a polar molecule, which enhances its solubility in polar solvents such as water.
  • Hydrogen Bonding: The -OH group is capable of forming hydrogen bonds with water molecules, contributing to a higher solubility in aqueous environments.
  • Solvent Interaction: This compound is more soluble in solvents that can engage in dipole-dipole interactions, such as alcohols or various organic solvents.
  • Temperature Dependency: As with many chemical compounds, the solubility of 2-nitropyridin-3-ol may increase with temperature, highlighting the relationship between thermal energy and solute solubility.

In summary, the solubility of 2-nitropyridin-3-ol is significantly influenced by its polar characteristics and the presence of functional groups capable of hydrogen bonding. This makes it a versatile compound in scenarios where solubility is a critical factor.

Interesting facts

Interesting Facts about 2-Nitropyridin-3-ol

2-Nitropyridin-3-ol is an intriguing compound that displays unique chemical properties and significant applications in various fields. Here are some fascinating aspects of this versatile compound:

  • Structural Significance: The presence of both a nitro group and a hydroxyl group on the pyridine ring contributes to its reactivity. This position is vital as it determines how the compound behaves in chemical reactions, particularly in nucleophilic substitutions.
  • Applications in Synthesis: 2-Nitropyridin-3-ol serves as a valuable intermediate in the synthesis of pharmaceuticals. Its reactivity allows chemists to create complex molecules efficiently, making it a staple in medicinal chemistry.
  • Biological Relevance: This compound has shown potential biological activity, particularly in the development of agents that can act against various diseases. Research continues to explore how modifications to its structure can enhance its efficacy in drug design.
  • Analytical Utility: Due to its distinct functional groups, 2-nitropyridin-3-ol can be utilized as a reagent in chemical analysis, particularly in identifying and quantifying certain compounds in mixtures.
  • Environmental Implications: The study of nitro compounds, including 2-nitropyridin-3-ol, is crucial for environmental chemistry, especially concerning pollution and its degradation products.

“The ability to bridge organic synthesis and biological applications showcases the importance of 2-nitropyridin-3-ol in modern chemistry.”

For students and professionals alike, delving into the world of compounds like 2-nitropyridin-3-ol opens up new avenues of research and discovery, pushing the boundaries of what is known in chemistry.

Synonyms
3-Hydroxy-2-nitropyridine
15128-82-2
2-Nitro-3-pyridinol
3-PYRIDINOL, 2-NITRO-
UU357X85YB
NSC-97501
DTXSID6022264
DTXCID002264
239-191-2
604-788-2
2-Nitropyridin-3-ol
2-Nitro-3-hydroxypyridine
15128-08-2
MFCD00006258
NSC 97501
2-nitro-3-hydroxy pyridine
EINECS 239-191-2
BRN 0124473
UNII-UU357X85YB
2-Nitro-3-hydroxypyridine; 3-Hydroxy-2-nitropyridine; NSC 97501
NSC97501
2-Nitro-3-pyridol
3-Hydroxynitropyridine
3-hydroxy-nitropyridine
2-Nitro-pyridin-3-ol
Vonoprazan Impurity 133
3-hydroxy-2-nitro-pyridine
SCHEMBL245234
SCHEMBL5643188
SCHEMBL19440715
SCHEMBL20503674
SCHEMBL30954607
3-Hydroxy-2-nitropyridine, 97%
SBB004168
AKOS000120717
AB00667
AC-2811
CS-W008612
FH00801
PS-5447
BP-11548
SY002996
DB-016010
H0764
NS00051394
ST50989333
EN300-17321
F10654
Q27291274
Z56921159
F0001-0541
InChI=1/C5H4N2O3/c8-4-2-1-3-6-5(4)7(9)10/h1-3,8