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Nimodipine

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Identification
Molecular formula
C21H24N2O7
CAS number
66085-59-4
IUPAC name
2-[nitroso-(1,7,7-trimethylnorbornan-2-yl)amino]acetic acid
State
State

At room temperature, nimodipine is in a solid state. This state makes it suitable for formulation into tablet or capsule pharmaceutical forms for ease of oral administration.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
524.30
Boiling point (Kelvin)
797.50
General information
Molecular weight
418.45g/mol
Molar mass
418.4510g/mol
Density
1.2000g/cm3
Appearence

Nimodipine appears as a white to pale yellow crystalline powder. It is practically insoluble in water but dissolves freely in acetone, methanol, and ethanol. Its appearance can vary slightly depending on purity and form, but it typically maintains a consistent white-yellow crystalline structure.

Comment on solubility

Solubility of 2-[Nitroso-(1,7,7-trimethylnorbornan-2-yl)amino]acetic Acid

The solubility of 2-[nitroso-(1,7,7-trimethylnorbornan-2-yl)amino]acetic acid in various solvents can provide valuable insights into its chemical behavior and potential applications. The overall solubility is influenced by a range of factors, including:

  • Polarity of the solvent: Generally, polar solvents such as water tend to dissolve polar compounds well, while nonpolar solvents may dissolve nonpolar compounds better.
  • Functional groups: The presence of carboxylic acid groups (-COOH) can enhance solubility in water due to hydrogen bonding.
  • Temperature: Increased temperature typically enhances solubility for many solids in liquids.
  • pH of the solution: The ionization of carboxylic acids can be influenced by pH, further affecting solubility.

For 2-[nitroso-(1,7,7-trimethylnorbornan-2-yl)amino]acetic acid, it can be anticipated that:

  • At neutral pH, the compound may exhibit moderate solubility in water.
  • In alkaline conditions, its solubility may increase due to deprotonation of the carboxylic acid group.
  • In organic solvents, solubility could vary widely, with potential solubility in less polar solvents.

Ultimately, the solubility of this compound exemplifies the intricate relationships between structure and solvent interactions, illustrating the complexity of chemical behavior in diverse environments.

Interesting facts

Interesting Facts about 2-[Nitroso-(1,7,7-trimethylnorbornan-2-yl)amino]acetic Acid

This unique compound, known for its intriguing structure and properties, falls into the category of nitroso compounds, which are renowned for their distinctive nitroso group (–N=O). Below are some fascinating insights about 2-[nitroso-(1,7,7-trimethylnorbornan-2-yl)amino]acetic acid:

  • Structural Complexity: The compound possesses a complex molecular structure featuring a nitroso group attached to a bicyclic norbornane derivative. This complexity can lead to unique chemical behaviors and interactions.
  • Biological Significance: Similar nitroso compounds often exhibit biological activities, making the study of this compound important for medicinal chemistry. Researchers are investigating how such compounds can impact biological systems, particularly in the area of drug design.
  • Versatile Reactivity: Nitroso compounds are known for their reactivity. They can serve as intermediates in a variety of organic reactions, particularly in the synthesis of more complex molecules. This compound could potentially act as an intermediate in the development of novel pharmaceuticals.
  • Environmental Considerations: The presence of nitroso compounds in the environment raises questions about their stability and potential impacts. Understanding how compounds like this degrade or transform under various conditions can provide insights into environmental chemistry.
  • Chemical Synthesis: The synthesis of compounds with such nitroso functionality often involves specific methodologies, highlighting the importance of reaction conditions and reagents. Enthusiasts of organic synthesis would find the pathways to create this compound particularly engaging.

Overall, the exploration of 2-[nitroso-(1,7,7-trimethylnorbornan-2-yl)amino]acetic acid opens avenues not only in synthetic chemistry but also in understanding the molecular intricacies that govern biological functions and reactivity.

Synonyms
(+-)-endo-N-2-Bornyl-N-nitrosoglycine
GLYCINE, N-2-BORNYL-N-NITROSO-, endo-(+-)-
24634-79-5
RefChem:346542
DTXSID60947563
[Nitroso(1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino]acetic acid