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N-Nitrosoguanidine

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Identification
Molecular formula
C2H6N4O
CAS number
70-25-7
IUPAC name
2-nitrosoguanidine
State
State

N-Nitrosoguanidine is typically found in a solid state at room temperature.

Melting point (Celsius)
163.00
Melting point (Kelvin)
436.15
Boiling point (Celsius)
183.00
Boiling point (Kelvin)
456.15
General information
Molecular weight
103.09g/mol
Molar mass
103.0930g/mol
Density
1.6930g/cm3
Appearence

N-Nitrosoguanidine typically appears as a yellow crystalline solid. It may be hygroscopic and has a distinct crystalline structure that can be seen with the naked eye.

Comment on solubility

Solubility of 2-nitrosoguanidine

2-nitrosoguanidine, with the chemical formula C2H4N4O, exhibits notable solubility characteristics that are important for various applications in research and industry.

When discussing the solubility of 2-nitrosoguanidine, it's essential to consider the following points:

  • Solvent Interaction: 2-nitrosoguanidine is generally soluble in polar solvents such as water, which is attributed to its functional groups that can engage in hydrogen bonding.
  • Temperature Dependency: The solubility may increase with temperature, allowing for more effective dissolution in solution during experimental procedures.
  • Concentration Effects: At higher concentrations, 2-nitrosoguanidine can lead to saturation, resulting in a decrease in solubility.

In summary, while 2-nitrosoguanidine is soluble in water due to its polar characteristics, the exact degree of solubility can vary based on factors such as temperature and concentration. As one researcher noted, "Understanding the solubility is key for its practical applications in biochemical contexts."

Interesting facts

Interesting Facts about 2-Nitrosoguanidine

2-Nitrosoguanidine, often abbreviated as NG, is a fascinating compound that plays a significant role in both scientific research and industrial applications. Here are some intriguing insights about this compound:

  • Chemical Structure: 2-nitrosoguanidine features a unique structure characterized by a nitroso group attached to a guanidine molecule, which contributes to its reactivity and biological significance.
  • Mutagenicity: This compound is well-known for its mutagenic properties, making it a vital subject of study in genetic research. It has been used in numerous experiments to investigate the mechanisms by which mutations arise in DNA.
  • Applications: Beyond its role in genetic studies, 2-nitrosoguanidine is utilized in the synthesis of various pharmaceutical agents, helping to enhance drug development processes.
  • Carcinogenic Nature: Studies have shown that 2-nitrosoguanidine can exhibit carcinogenic effects, emphasizing the importance of proper handling and safety measures when working with it in laboratory environments.
  • Research Implications: The compound is frequently employed in the field of cancer research as a way to model tumorigenesis, thereby contributing to our understanding of cancer biology.

Overall, 2-nitrosoguanidine serves as a critical tool in the field of chemistry, particularly in the study of DNA damage and repair mechanisms, providing insights that are essential for advancing our understanding of genetics and potential therapeutic approaches.

Synonyms
Nitrosoguanidine
674-81-7
N-Nitrosoguanidine
Nitrosoguanidin
GUANIDINE, NITROSO-
Nitrosoguanidin [German]
Guanidine, N-nitroso-
CCRIS 2194
UNII-Z0FDZ0E0AE
Z0FDZ0E0AE
NSC 33670
Initiating explosive nitrosoguanidine (DOT)
NSC-33670
DTXSID40217756
NNitrosoguanidine
Guanidine, nitroso
DTXCID90140247
2-nitrosoguanidine
1-nitrosoguanidine
Nitrosoguanidine (wetted with ca. 20% Water, containing 5g on a dry weight basis),
Nitrosoguanidines
isonitroso-guanidine
n-nitroso-guanidine
Initiating explosive nitrosoguanidine
WLN: ONMYZUM
CHEMBL447467
WTLKTXIHIHFSGU-UHFFFAOYSA-N
NSC33670
AKOS006223226
AKOS040768883
DB-298771
N0325
Q27294836