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Benzoylformic acid

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Identification
Molecular formula
C8H6O3
CAS number
611-72-3
IUPAC name
2-oxo-2-phenyl-acetic acid
State
State

This compound is typically found in solid state at room temperature. It is a stable compound under ordinary conditions of use and storage.

Melting point (Celsius)
61.00
Melting point (Kelvin)
334.00
Boiling point (Celsius)
274.00
Boiling point (Kelvin)
547.00
General information
Molecular weight
150.13g/mol
Molar mass
150.1290g/mol
Density
1.3200g/cm3
Appearence

Benzoylformic acid appears as a white solid or crystalline powder. It is known to be stable under normal conditions but should be kept away from strong oxidizing agents.

Comment on solubility

Solubility of 2-oxo-2-phenyl-acetic acid

2-oxo-2-phenyl-acetic acid, with the chemical formula C9H8O3, exhibits notable solubility characteristics that are important for its applications. Understanding its solubility can greatly influence its usage in various chemical processes and formulations.

  • Solvent Interaction: This compound is generally soluble in polar solvents such as water, ethanol, and methanol. Its ability to interact with these solvents is primarily due to the presence of the carboxylic acid group, which readily ionizes to form hydrogen bonds.
  • Temperature Dependency: The solubility of 2-oxo-2-phenyl-acetic acid can increase with temperature. As the temperature rises, the kinetic energy of the molecules increases, often leading to enhanced solubility.
  • pH Influence: The solubility is also influenced by the pH of the solution. In alkaline conditions, deprotonation occurs, leading to higher solubility due to increased ionization.
  • Limited Solubility in Non-Polar Solvents: Conversely, this compound shows poor solubility in non-polar solvents (like hexane or toluene). This is due to the lack of hydrogen bonding capability in non-polar environments.

In summary, 2-oxo-2-phenyl-acetic acid's solubility properties can be summarized as follows:

  1. Soluble in polar solvents
  2. Increased solubility with rising temperature
  3. Higher solubility in alkaline conditions
  4. Poor solubility in non-polar solvents

Understanding these solubility traits is crucial when considering this compound's application in pharmaceutical and chemical industries. As the saying goes, "The solubility of a compound is often the key to its utility."

Interesting facts

Interesting Facts about 2-Oxo-2-phenyl-acetic Acid

2-Oxo-2-phenyl-acetic acid, often referred to as phenylglyoxylate, is a fascinating compound with diverse applications in various fields. Here are some intriguing aspects of this compound:

  • Key Role in Synthesis: This compound serves as an important intermediate in organic synthesis, particularly in the production of pharmaceuticals and fine chemicals. Its structure allows for the easy formation of other complex molecules.
  • Biochemical Significance: 2-Oxo-2-phenyl-acetic acid plays a role in biological processes. It has been studied for its potential interactions with metabolic pathways, including those involving amino acids and their derivatives.
  • Analytical Chemistry: It is used in various analytical techniques, such as chromatography, due to its distinct properties that help in the separation and identification of different compounds.
  • Natural Occurrence: Certain natural products contain similar structural features, making this compound interesting for scientists studying nature's chemistry and its implications in drug discovery.
  • Multifunctionality: The compound exhibits both acidic and ketone characteristics, which can lead to diverse chemical reactions such as aldol condensation, highlighting its multifunctional nature.

Quote to Remember

"In the world of chemistry, every compound tells a story. The more we learn, the richer the narrative." - Anonymous

In conclusion, 2-oxo-2-phenyl-acetic acid is not just another compound; it is a gateway to numerous synthetic pathways and biological investigations. Understanding its features not only broadens our knowledge but also fuels innovation in chemical research.

Synonyms
BENZOYLFORMIC ACID
Phenylglyoxylic acid
611-73-4
2-Oxo-2-phenylacetic acid
Oxophenylacetic acid
Benzeneglyoxylic acid
Phenylgloxylic acid
oxo(phenyl)acetic acid
Phenyloxoacetic acid
2-Phenylethanoic acid
Benzoylformate
Phenylglyoxalate
Glyoxylic acid, phenyl-
alpha-Ketophenylacetic acid
Formic acid, benzoyl-
alpha-Oxobenzeneacetic acid
BENZOYL-FORMIC ACID
Benzeneacetic acid, a-oxo-
Benzeneacetic acid, alpha-oxo-
Benzeneacetic acid, .alpha.-oxo-
alpha-Oxo-benzeneacetic acid
MFCD00002575
Benzoyl formic acid
.alpha.-Ketophenylacetic acid
CHEMBL950
2PZL5A0W0M
CHEBI:18280
2-OXO-2-PHENYLETHANOIC ACID
NSC-28293
Oxophenylacetic Acid (Benzoylformic Acid)
ACETIC ACID,OXO,PHENYL (PHENYLGLYOXYLIC ACID)
EINECS 210-278-7
NSC 28293
UNII-2PZL5A0W0M
BRN 0606718
2-oxo-2-phenyl-acetic acid
AI3-26708
Glycopyrronium Bromide Imp. B (EP); Oxophenylacetic Acid; Benzoylformic Acid; Glycopyrronium Bromide Impurity B; Glycopyrronium Impurity B
HPGO
phenyl glyoxalic acid
phenyl glyoxylic acid
a-Oxophenylacetic acid
oxo-phenyl-acetic acid
a-Ketophenylacetic acid
a-Oxobenzeneacetic acid
WLN: QVVR
alpha-Oxophenylacetic acid
2-Oxo-2-phenylaceticacid
bmse000743
Phenylglyoxylic acid, 97%
SCHEMBL38943
4-10-00-02737 (Beilstein Handbook Reference)
Glyoxylic acid, phenyl- (8CI)
DTXSID80209993
NSC28293
.ALPHA.-OXOBENZENEACETIC ACID
BDBM50102174
s6053
AKOS009158910
Benzeneacetic acid, alpha-oxo- (9CI)
CS-W010971
DB02279
FP26975
HY-W010255
s11007
AS-11992
SY004129
?-Oxobenzeneacetic acid;Benzoylformic acid
DB-002646
B1129
NS00015182
EN300-81664
Phenylglyoxylic acid, purum, >=98.0% (T)
C02137
AH-034/32845038
Q663909
GLYCOPYRRONIUM BROMIDE IMPURITY B [EP IMPURITY]
F0001-1606
Z381360894
InChI=1/C8H6O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5H,(H,10,11