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2-(p-Toluenesulfonamido)benzoic acid

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Identification
Molecular formula
C14H13NO4S
CAS number
933-87-9
IUPAC name
2-(p-tolylsulfonylamino)benzoic acid
State
State

In its pure form, 2-(p-Toluenesulfonamido)benzoic acid is a solid at room temperature. It is stable under normal conditions, but should be stored in a cool, dry place to prevent decomposition or moisture uptake, which can affect its physical properties.

Melting point (Celsius)
185.00
Melting point (Kelvin)
458.15
Boiling point (Celsius)
425.30
Boiling point (Kelvin)
698.45
General information
Molecular weight
293.33g/mol
Molar mass
293.3270g/mol
Density
1.3736g/cm3
Appearence

2-(p-Toluenesulfonamido)benzoic acid typically appears as a white to off-white crystalline powder. Its crystalline form reflects its well-defined molecular structure, making it important in chemical synthesis and research. The appearance can vary slightly depending on purity and handling, but generally, it maintains a consistent physical form when adequately stored.

Comment on solubility

Solubility of 2-(p-tolylsulfonylamino)benzoic acid

2-(p-tolylsulfonylamino)benzoic acid, also known as a sulfonamide compound, exhibits varying solubility characteristics influenced by its chemical structure. Understanding its solubility profile is crucial for applications in pharmaceuticals and materials science. Here are some key points to consider:

  • Polar Functional Groups: The presence of both the sulfonyl and amino groups contributes to the compound's polarity, enhancing its ability to solvate in polar solvents like water.
  • Aromatic Systems: The benzene ring can hinder complete solubility due to hydrophobic interactions, yet it often aids in solubilizing through π-π stacking in organic solvents.
  • pH Dependency: The solubility may also vary significantly with pH, as protonation or deprotonation of the carboxylic acid group changes its ionic state, influencing its solubility profile.
  • Common Solvents: It is generally soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide, while its solubility in water may be moderate, depending on the conditions.

As emphasized in chemical literature, “Solubility is key to the efficacy of a compound in biological systems.” Thus, determining the specific solubility of 2-(p-tolylsulfonylamino)benzoic acid across different environments is essential in predicting its behavior in practical applications.

Interesting facts

Interesting Facts about 2-(p-tolylsulfonylamino)benzoic acid

2-(p-tolylsulfonylamino)benzoic acid is a fascinating compound with various applications in both the pharmaceutical and chemical industries. Here are some noteworthy aspects of this compound:

  • Pharmaceutical Relevance: This compound is often explored for its potential therapeutic properties, particularly in the field of anti-inflammatory drugs.
  • Sulfonamide Connection: The sulfonamide moiety in its structure lends it unique properties that may be beneficial in drug design, especially for targeting bacterial infections.
  • Structural Features: The presence of both a benzoic acid and a sulfonylamino group enables it to participate in a variety of chemical reactions and syntheses, making it versatile for further modifications.
  • Research Opportunities: Scientists are exploring how this compound can be used as a scaffold for developing new molecules that may lead to innovative drugs.

In Conclusion

This compound serves as an excellent example of how chemical modifications can lead to materials with valuable properties. As research continues, it may unveil even more applications, underscoring the importance of compounds like 2-(p-tolylsulfonylamino)benzoic acid in advancing science and medicine.

Synonyms
2-{[(4-methylphenyl)sulfonyl]amino}benzoic acid
2-(4-methylbenzenesulfonamido)benzoic acid
2-(((4-Methylphenyl)sulfonyl)amino)benzoic acid
BENZOIC ACID, 2-(((4-METHYLPHENYL)SULFONYL)AMINO)-
BRN 2221158
DTXSID80212447
3-14-00-00950 (Beilstein Handbook Reference)
NSC 43530
2-[[(4-Methylphenyl)sulfonyl]amino]benzoic acid
Benzoic acid, 2-[[(4-methylphenyl)sulfonyl]amino]-
DTXCID80134938
684-751-5
6311-23-5
2-(Toluene-4-sulfonylamino)-benzoic acid
2-(4-methylphenylsulfonamido)benzoic acid
2-[(4-methylphenyl)sulfonylamino]benzoic acid
AKOS AU36-M212
2-[(4-methylbenzene)sulfonamido]benzoic acid
CHEMBL34534
2-(tosylamino)benzoic acid
2-(p-tolylsulfonylamino)-benzoic acid
NSC43530
tosylanthranilic acid
MFCD00045803
N-tosylanthranilic acid
N-tosyl anthranilic acid
CBMicro_012437
Cambridge id 5180213
SCHEMBL1688339
ALBB-029630
SMSF0004156
BDBM50016552
NSC-43530
STK020169
AKOS000129599
CB15638
SB38027
n-4-methylphenylsulfonylanthranilic acid
2-(4-methylphenylsulfonamido)benzoicacid
DA-27567
LS-10533
BIM-0012332.P001
2-((4-methylphenyl)sulfonamido)benzoic acid
CS-0261182
EN300-77504
G29733
SR-01000492946
SR-01000492946-1
Z45511840
F0777-0818